A5042561777- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Sleep and Wakefulness Research
- Tracheal and airway disorders
- Voice and Speech Disorders
- Sleep and related disorders
- Dysphagia Assessment and Management
- Cardiovascular and Diving-Related Complications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Asthma and respiratory diseases
- Heart Rate Variability and Autonomic Control
- Genetic Associations and Epidemiology
- Vestibular and auditory disorders
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- High Altitude and Hypoxia
- Genomics and Rare Diseases
- Gastroesophageal reflux and treatments
- Atrial Fibrillation Management and Outcomes
- Respiratory and Cough-Related Research
- Dietary Effects on Health
- Heart Failure Treatment and Management
- Cardiovascular Syncope and Autonomic Disorders
Université Laval
2016-2025
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2015-2024
McGill University Health Centre
2014
Université du Québec à Montréal
2014
Royal Victoria Hospital
2014
University of Toronto
2007-2010
Toronto General Hospital
2010
University Health Network
2010
Sorbonne Université
1999-2009
Université Paris Cité
2008-2009
The Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure trial tested the hypothesis that continuous positive airway pressure (CPAP) would improve survival rate without heart transplantation of patients who have central sleep apnea failure.
In the main analysis of Canadian Continuous Positive Airway Pressure (CPAP) for Patients with Central Sleep Apnea (CSA) and Heart Failure Trial (CANPAP), CPAP had no effect on heart transplant-free survival; however, only reduced mean apnea-hypopnea index to 19 events per hour sleep, which remained above trial inclusion threshold 15. This stratified CANPAP tested hypothesis that suppression CSA below this by would improve left ventricular ejection fraction survival.Of 258 failure patients in...
The identification of the areas quality life (QoL) most likely to be affected by obstructive sleep apnoea (OSA) would an important step in evaluation impact disease and its treatment modalities. objective this study was describe OSA on patients' QoL. A list 186 items potentially related QoL patients with constructed. From list, consecutive were asked, at time diagnosis, identify significant grade their importance a 5‐point scale. item determined from proportion who identified it as...
We investigated the influence of mouth opening on upper airway (UA) collapsibility in six healthy sleeping volunteers. UA was measured during continuous negative pressure trials that consisted progressive decrease a nasal mask, with simultaneous recording esophageal and instantaneous flow. Measurements were made under two experimental conditions: closed (MC), open (MO). Cephalometric measurements obtained subjects awake same position for both conditions. critical (Pcrit) derived from...
The Canadian Thoracic Society (CTS) guidelines for the diagnosis and treatment of sleep disordered breathing in adults were developed over past year. A one-day meeting was held Montreal, Quebec, on October 28, 2005, just before annual CTS meeting. facilitated by Dr R Davies (Oxford, United Kingdom), speakers included D Morrison (Halifax, Nova Scotia), J Kimoff (Montreal), Fleetham (Vancouver, British Columbia), C George (London, Ontario), M Kryger (Winnipeg, Manitoba), P Hanly (Calgary,...
Rationale In obstructive sleep apnea patients (OSA), continuous positive airway pressure (CPAP) adherence is crucial to improve symptoms and cardiometabolic outcomes. The choice of mask may influence CPAP but this issue has never been addressed properly. Objective To evaluate the impact nasal pillows, oronasal masks on in a cohort OSA. Methods Newly treated OSA participating “Observatoire Sommeil de la Fédération Pneumologie”, French national prospective cohort, were included between March...
Upper airway dilator muscles play an important role in the pathophysiology of sleep apnea hypopnea syndrome (SAHS). The mechanical and structural characteristics these remain unknown. aim this study was to compare physiologic, metabolic, fiber type one upper muscle (musculus uvulae, MU) 11 SAHS seven nonapneic snorers. different analyses were done on MU obtained during uvulo-palato-pharyngoplasty. Snorers differed only their + indices (11.5 +/- 5.9 34.2 14.6/h, respectively, mean SD)....
The impact of continuous positive airway pressure (CPAP) treatment on the responsiveness asthmatic subjects with obstructive sleep apnoea (OSA) has scarcely been studied. A prospective study was performed comparing changes in and quality life stable OSA patients, before 6 weeks after their nocturnal CPAP treatment. total 20 (11 males nine females) participated study. With treatment, apnoea/hypopnoea index dropped from 48.1±23.6·h -1 to 2.6±2.5·h . There were no significant (provocative...
We tested the hypotheses that in patients with congestive heart failure (CHF) and sleep disordered breathing (SDB) auto-servoventilation (ASV) improves cardiac function quality of life. Between March 2007 September 2009, stable CHF (left ventricular ejection fraction (LVEF) ≤40%) SDB (apnoea/hypopnoea index ≥20 events·h −1 ) were randomised to receive either ASV (BiPAP (Philips Respironics, Murrysville, PA, USA), n=37) optimal medical management, or management alone (n=35). Outcomes assessed...
<h3>Objective</h3> It is unclear whether objectively measured maternal sleep-disordered breathing (SDB) leads to poor fetal outcomes. In this study, we prospectively assessed polysomnography-based diagnosis of SDB in the third trimester associated with delivery small for gestational age (SGA) infants. <h3>Study design</h3> Participants were recruited from a multicentre pregnancy cohort study. Eligible participants evaluated based on symptoms (snoring and/or witnessed apnoeas using Pittsburgh...
Genioglossus (GG) activity has been extensively studied by electromyographic recordings in the investigation of pathophysiology sleep apnea-hypopnea syndrome (SAHS). However, effective force developed this upper airway (UA) dilator muscle depends on its metabolic and histochemical characteristics. The aim study was to compare fiber type characteristics two UA muscles, musculus uvulae (MU) GG, 17 patients with SAHS 11 nonapneic snorers. MU GG samples were obtained during...
The total upper airway resistances are modified during active changes in lung volume. We studied nine normal subjects to assess the influence of passive thoracopulmonary inflation and deflation on nasal pharyngeal resistances. With lying an iron lung, volumes were changed by application extrathoracic pressure (Pet) from 0 20 (+Pet) or -20 cmH2O (-Pet) 5-cmH2O steps. Upper pressures measured with two low-bias flow catheters, one at tip epiglottis other posterior nasopharynx. Breath-by-breath...
<h3>BACKGROUND</h3> Nasal pressure tracing is now being used to measure breathing in ambulatory screening devices for sleep apnoea but it has not been compared with other methods of assessment. <h3>METHODS</h3> Sleep induced disorders were scored by three different analysis (thermistry, inductive plethysmography, and nasal tracing) 193 consecutive patients referred our laboratory. With the conventional thermistry method an was defined as absence oronasal flow on thermistor signal ⩾10 s a...
Excess visceral adiposity and sleep apnoea are two conditions independently associated with cardiovascular diseases. The often combined believed to interact in a vicious circle.To compare the response of men obesity or without syndrome 1-year healthy eating, physical activity/exercise intervention programme.77 men, selected on basis increased waist circumference (≥90 cm) dyslipidaemia (triglycerides ≥1.69 and/or high-density lipoprotein (HDL) cholesterol <1.03 mmol/litre), participated this...
Abstract Study Objectives Obstructive sleep apnea (OSA) increases the risk of cognitive impairment. Measures microarchitecture from EEG may help identify patients at this complication. Methods Participants with suspected OSA (n = 1142) underwent in-laboratory polysomnography and completed medical history questionnaires, tests global cognition (Montreal Cognitive Assessment, MoCA), memory (Rey Auditory Verbal Learning Test, RAVLT) information processing speed (Digit–Symbol Coding, DSC)....
In patients with heart failure (HF), the predominant type of sleep apnoea can change over time in association alterations circulation time. The aim this study was to determine whether, some HF, a spontaneous shift from mainly central (>50% events) obstructive (CSA and OSA, respectively) coincides improvement left ventricular ejection fraction (LVEF). Therefore, studies LVEFs HF CSA control arm Canadian Continuous Positive Airway Pressure for Patients Central Sleep Apnea Heart Failure...
The present position paper on the use of portable monitoring (PM) as a diagnostic tool for obstructive sleep apnea/hypopnea (OSAH) in adults was based consensus and expert opinion regarding best practice standards from stakeholders across Canada. These recommendations were prepared to guide appropriate clinical this new technology ensure that quality assurance are adhered to. Clinical guidelines PM diagnosis management OSAH an alternative in-laboratory polysomnography published by American...
Abstract Study Objectives Chronic kidney disease (CKD) is a global health concern and major risk factor for cardiovascular morbidity mortality. Obstructive sleep apnea (OSA) may exacerbate this by contributing to the development of CKD. This study investigated prevalence patient awareness CKD progression in individuals with OSA. Methods Adults referred five Canadian academic centers suspected OSA completed questionnaire, home test or in-lab polysomnography provided blood urine samples...
RATIONALE Adherence to Continuous Positive Airway Pressure (CPAP) for Obstructive Sleep Apnoea (OSA) continues be low with high termination rates. Alternative therapies CPAP are needed. OBJECTIVES To compare objective adherence and Mandibular Advancement Splints (MAS) evaluate their effectiveness. Additionally, identify treatment usage patterns the clinical effectiveness of having both therapies. METHODS This multi-center, double-randomized, three-phase trial...
Treatment of sleep apnea–hypopnea syndrome (SAHS) by fixed continuous positive airway pressure (CPAP) requires an in-laboratory titration procedure to determine the effective level (Peff ). We recently reported that one auto-CPAP machine can be used without study allowing Peff determination. The aim this was evaluate accuracy auto CPAP trial at home. A 1- or 2-wk automatic done home in 40 patients estimating reference (Pref ) set and a Pref + 3 cm H2O/ − 4 H2O interval. then determined...
We evaluated the efficiency of two different treatment procedures with continuous positive airway pressure (CPAP) on sleep, nocturnal breathing characteristics and daytime vigilance in 18 newly diagnosed patients untreated sleep apnoea/hypopnoea syndrome (SAHS) randomly allocated to groups. In group I, (PP) level was set suppress flow limitation (PFL), while II PP at a that eliminated only snoring (PAHS). At end 3 week period home CPAP therapy, follow-up study, cognitive tests were made....
We investigated the influence of weight and obstructive sleep apnea status on inflammatory histologic features uvula. Tissue samples resected during uvulopalatopharyngoplasty in 11 snorers without apnea, subjects with similar body mass index age, 8 additional obese were examined by immunohistochemistry staining techniques. The frequency distribution immune cells, amount collagen, integrity elastin fiber network evaluated proximal distal uvular sections. T cell (CD4+, CD8+) macrophage counts...