A5027723988- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Dysphagia Assessment and Management
- Sleep and Wakefulness Research
- Voice and Speech Disorders
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Heart Rate Variability and Autonomic Control
- Cardiovascular and Diving-Related Complications
- Cleft Lip and Palate Research
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Trigeminal Neuralgia and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vestibular and auditory disorders
- Sleep and related disorders
- Muscle activation and electromyography studies
- Restraint-Related Deaths
- Neurological disorders and treatments
- Gastroesophageal reflux and treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cerebral Venous Sinus Thrombosis
- Sleep and Work-Related Fatigue
- High Altitude and Hypoxia
Université Laval
2012-2024
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2012-2024
Abstract Study Objectives Obstructive sleep apnea (OSA) increases the risk of cognitive impairment. Measures microarchitecture from EEG may help identify patients at this complication. Methods Participants with suspected OSA (n = 1142) underwent in-laboratory polysomnography and completed medical history questionnaires, tests global cognition (Montreal Cognitive Assessment, MoCA), memory (Rey Auditory Verbal Learning Test, RAVLT) information processing speed (Digit–Symbol Coding, DSC)....
Abstract Study Objectives Chronic kidney disease (CKD) is a global health concern and major risk factor for cardiovascular morbidity mortality. Obstructive sleep apnea (OSA) may exacerbate this by contributing to the development of CKD. This study investigated prevalence patient awareness CKD progression in individuals with OSA. Methods Adults referred five Canadian academic centers suspected OSA completed questionnaire, home test or in-lab polysomnography provided blood urine samples...
Abstract Study Objectives Obstructive sleep apnea (OSA), fragmentation, and short duration (SD) have been associated with chronic kidney disease (CKD). However, these potential mechanisms for CKD not compared in the same cohort. This study investigated independent combined impact of OSA insomnia on risk progression a clinic population. Methods In cross-sectional design, adults suspected completed an overnight questionnaire that included Insomnia Severity Index (ISI) Pittsburgh Sleep Quality...
Transcranial magnetic stimulation (TMS) can activate the corticobulbar system and briefly recruit upper airway dilator muscles, improving inspiratory airflow dynamics of flow-limited respiratory cycles during sleep. The purpose this investigation was to quantify effects TMS-induced twitches applied sleep on in 14 obstructive apnoea patients. Submental muscle motor threshold (SUB(MT)) motor-evoked potential (SUB(MEP)) were examined wakefulness stable non-rapid eye movement (NREM) sleep,...
The aim of the present study was to assess effects one-week tongue-task training (TTT) on sleep apnea severity in subjects. Ten patients with (seven men, mean [± SD] age 52±8 years; apnea-hypopnea [AHI] index 20.9±5.3 events/h) underwent 1 h TTT authors’ laboratory seven consecutive days. A complete or limited recording and tongue maximal protruding force were assessed before after TTT. One-week associated a global AHI decrease (pre-TTT: events/h; post-TTT: 16.1±5.1 P<0.001) during rapid...
What is the central question of this study? A transcranial magnetic stimulation (TMS)-induced twitch applied on isolated single breaths over motor cortex somatotopic representation tongue briefly recruits submental muscles and improves airflow dynamics flow-limited respiratory cycles without arousing sleep apnoea patients. However, mechanical impact TMS-induced during consecutive breathing remains unknown. main finding what its importance? Our results show that application TMS with...
Inadequate upper airway (UA) dilator muscle function may play an important role in the pathophysiology of obstructive sleep apnea (OSA). To date, tongue mechanical properties have been assessed mainly using protrusion protocol with conflicting results. Performance during elevation tasks among patients OSA remains unknown. This study aimed at assessing strength, strength stability, endurance time, fatigue indices, and total work, repetitive isometric fatiguing contractions 12 normal plus...
Functional interaction between upper airway (UA) dilator muscles and the diaphragm is crucial in maintenance of UA patency. This could be altered by increasing respiratory drive. The aim our study was to compare effects hypercapnic stimulation on genioglossus corticomotor responses transcranial magnetic (TMS).10 self-reported healthy men (32 ± 9 yr; body mass index = 24 3 kg/m(-2)) breathed, random order, room air or 5% then 7% Fi(CO(2)), both balanced with pure O(2). Assessments included...
We tested the hypothesis that stimulating genioglossus by repetitive transcranial magnetic stimulation (rTMS) during ascendant portion of inspiratory flow airflow-limited breaths would sustain recruitment upper airway dilator muscles over time and improve dynamics without arousing obstructive sleep apnea (OSA) patients. In a cross-sectional design, nine OSA patients underwent rTMS trial stable non-rapid eye movement (NREM) sleep. Submental muscle motor threshold (SUB) motor-evoked potential...
What is the central question of this study? Can repetitive transcranial magnetic stimulation (rTMS) genioglossus enhance beneficial effects observed with single twitches on upper airway mechanical properties? main finding and its importance? We found that both inspiratory expiratory rTMS protocols induce a different activation pattern muscles, evidence for an increase in corticomotor excitability response to rTMS. This major importance because it might open door goal increasing and, thus,...
Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a prevalent condition affecting substantial portion of the global population, with its prevalence increasing over past 2 decades. OSAHS characterized by recurrent upper airway (UA) closure during sleep, leading to significant impacts on quality life and heightened cardiovascular metabolic morbidity. Despite continuous positive pressure (CPAP) being gold standard treatment, patient adherence remains suboptimal due various factors, such as...
Summary Corticomotor excitability of peripheral muscles appears to be altered in patients with obstructive sleep apnea. However, there is no evidence such alteration for upper airway/respiratory that are involved the pathophysiology this disease. The aim study was compare effects hypercapnic stimulation on diaphragm and genioglossus corticomotor awake healthy subjects versus assessed by transcranial magnetic 12 untreated apneic men (48 ± 10 years; body mass index = 28.9 4.7 kg m −2 ;...
Phrenic nerve magnetic stimulation (PNMS) performed anterolaterally at the base of neck (BAMPS) and cervical are common techniques for assessing upper airway (UA) mechanical properties in conscious humans. We considered that if NMS sternal level (a-MS) could induce a similar percentage flow-limited twitches as BAMPS subjects, gauging UA dynamic by PNMS would be simplified. Instantaneous flow, pharyngeal esophageal pressures, well thoraco-abdominal motion were recorded 10 sleep apnea...
In-lab mandibular protrusive titration using a remotely controlled positioner (RCMP) could predict the success rate of advancement device (MAD) and reliably determine Optimal Protrusive Position (OPP) for obstructive sleep apnea (OSA) patients. The aim this study was to compare MAD in-lab RCMP manual performed in Caucasian Chinese OSA patients.Manual during an same procedure that had been previously reported untreated Success determined according classical criteria or those used titration.A...