A5076371474- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Sleep and Wakefulness Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Restless Legs Syndrome Research
- Sleep and related disorders
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and Diving-Related Complications
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Genetic Syndromes and Imprinting
- Airway Management and Intubation Techniques
- Pulmonary Hypertension Research and Treatments
- Diagnosis and Treatment of Venous Diseases
- Neurogenetic and Muscular Disorders Research
- Sleep and Work-Related Fatigue
- Multiple Sclerosis Research Studies
- Venous Thromboembolism Diagnosis and Management
- Asthma and respiratory diseases
- Voice and Speech Disorders
- Cardiac Arrest and Resuscitation
- Epigenetics and DNA Methylation
University of Cagliari
2022-2025
Pitié-Salpêtrière Hospital
2014-2024
Sorbonne Université
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Azienda Ospedaliero-Universitaria Cagliari
2024
Hôpital Charles-Foix
2014-2022
Inserm
2011-2022
Neurophysiologie respiratoire expérimentale et clinique
2014-2022
Centre Hospitalier Universitaire de Poitiers
2022
Université Paris Cité
2014-2021
Background— Obstructive sleep apnea (OSA) and central are common in patients with heart failure. We hypothesized that such patients, severity of OSA is related to overnight rostral leg fluid displacement increase neck circumference, P co 2 , continuous positive airway pressure alleviates association prevention accumulation the neck. Methods Results— In 57 failure (ejection fraction ≤45%), we measured change volume circumference before after polysomnography, transcutaneous during...
The cause of increased pharyngeal collapsibility in patients with obstructive sleep apnea is incompletely understood. In awake healthy subjects, we showed that fluid displacement from the legs into neck induced by lower body positive pressure reduces upper airway size and increases its collapsibility. Prolonged sitting leads to dependent accumulation legs.To test hypotheses apnea-hypopnea index (AHI) during will be related amount spontaneously displaced overnight, this will, turn, time spent...
Faced with mechanical inspiratory loading, awake animals and anaesthetized humans develop alveolar hypoventilation, whereas do defend ventilation. This points to a suprapontine compensatory mechanism instead of or in addition the 'traditional' brainstem respiratory regulation. study assesses role cortical pre-motor representation muscles this behaviour. Ten healthy subjects (age 19-34 years, three men) were studied during quiet breathing, CO2-stimulated resistive threshold self-paced...
Fluid accumulation in the legs and its overnight redistribution into neck appears to play a causative role obstructive sleep apnea (OSA) sedentary men. Chronic venous insufficiency (CVI) promotes fluid that can be counteracted by compression stockings.To test hypotheses that, nonobese subjects with CVI OSA, wearing stockings during day will attenuate OSA reducing amount of displaced overnight.Nonobese were randomly assigned 1 week or 1-week control period without stockings, after which they...
The characteristics of residual excessive sleepiness (RES), defined by an Epworth score >10 in adequately treated apnoeic patients, are unknown. 40 with (n = 20) and without RES, 20 healthy controls underwent clinical interviews, cognitive biological tests, polysomnography, a multiple sleep latency test, 24-h monitoring. marked subjective the RES group (mean± sd 16.4±3) contrasted moderately abnormal objective measures (90% patients had daytime latencies >8 min). Compared more fatigue,...
Fluid shift from the legs to neck induced by LBPP (lower-body positive pressure) increases UA (upper airway) collapsibility in healthy men. Rostral fluid displacement during recumbency may therefore contribute pathogenesis of OSA (obstructive sleep apnoea). There is a higher prevalence men than women. We hypothesized that more response rostral was assessed healthy, non-obese and women while awake determining Pcrit (critical closing application different suction pressures UA. Subjects were...
<i>Background:</i> Nonobese diabetics with diabetic autonomic neuropathy (DAN) show an elevated prevalence of obstructive sleep apnea-hypopnea (OSAH). <i>Objective:</i> It was the aim this study to assess if presence DAN could further increase risk developing OSAH in obese diabetics. <i>Methods:</i> Eighteen patients, 8 [age 57 ± 5 years, body mass index (BMI) 35 4] and 10 without (age 56 BMI 37 5), were recruited. Ten age-matched subjects studied as...
In amyotrophic lateral sclerosis (ALS) patients, respiratory insufficiency is a major burden. Diaphragm conditioning by electrical stimulation could interfere with lung function decline promoting the development of type 1 muscle fibres. We describe an ancillary study to prospective, non-randomized trial (NCT00420719) assessing effects diaphragm pacing on forced vital capacity (FVC). Sleep-related disturbances being early clues diaphragmatic dysfunction, we postulated that they would provide...
Abstract Study Objectives Excessive sleepiness is a common symptom in Prader–Willi syndrome (PWS), and it negatively impacts the quality of life. Obstructive sleep apnea narcolepsy phenotypes have been reported PWS. We characterized disorders large cohort adults with Methods All consecutive patients genetically confirmed PWS unselected for sleep-related symptoms, underwent clinical interview, polysomnography, multiple latency tests (MSLT, n = 60), followed by long-term (24 hours)...
In heart failure (HF), we observed two patterns of hyperpnea during Cheyne-Stokes respiration with central sleep apnea (CSR-CSA): a positive pattern where end-expiratory lung volume remains at or above functional residual capacity, and negative it falls below capacity. We hypothesized the is associated worse HF.
Spinal Muscular Atrophy (SMA) is a genetic neuromuscular disorder caused by the mutation of survival motor neuron 1 (SMN1) gene. Sleep disturbances and their impact on mental health quality life in patients with SMA are being understudied, most evidence comes from pediatric patients. We conducted cross-sectional survey adult SMA. The participants underwent questionnaires exploring sleep Pittsburgh Quality Index (PSQI), depressive symptoms Patient Health Questionnaire-9 (PHQ-9), Short-Form...