A5078527014- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cardiovascular and Diving-Related Complications
- Respiratory Support and Mechanisms
- Sleep and Wakefulness Research
- COVID-19 and healthcare impacts
- Cardiovascular Disease and Adiposity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- COVID-19 diagnosis using AI
- Neonatal Respiratory Health Research
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Cardiac tumors and thrombi
- Polyomavirus and related diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Adipokines, Inflammation, and Metabolic Diseases
- Dysphagia Assessment and Management
- Regulation of Appetite and Obesity
- Sleep and related disorders
- Pulmonary Hypertension Research and Treatments
- Eosinophilic Disorders and Syndromes
Bellvitge University Hospital
2013-2024
Institut d'Investigació Biomédica de Bellvitge
2013-2024
Universitat de Barcelona
2020-2024
Centre for Biomedical Network Research on Rare Diseases
2020-2021
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2011-2020
Research Network (United States)
2020
Université Joseph Fourier
2012-2013
Inserm
2012-2013
Summary Hypoxic brain damage might explain persistent sleepiness in some continuous positive airway pressure‐compliant obstructive sleep apnea called residual excessive sleepiness. Although pressure may not be fully efficient treating this symptom, wake‐promoting drug prescription is no longer allowed by the E uropean M edicines A gency. The aim of study to describe phenotypes a large prospective sample patients with apnea. Residual was defined an pworth S leepiness cale score ≥ 11. Eligible...
Home respiratory polygraphy may be a simpler alternative to in-laboratory polysomnography for the management of more symptomatic patients with obstructive sleep apnea, but its effectiveness has not been evaluated across broad clinical spectrum.To compare long-term (6 mo) home and protocols in intermediate-to-high apnea suspicion (most requiring study).A multicentric, noninferiority, randomized controlled trial two open parallel arms cost-effectiveness analysis was performed 12 tertiary...
Obstructive sleep apnea (OSA) is associated with an increased prevalence of metabolic syndrome (MetS), even in patients morbid obesity. Our goal was to address whether continuous positive airway pressure (CPAP) treatment improved glucose metabolism this population.A prospective randomized controlled trial performed severe OSA obesity without diabetes two university referral hospitals. Patients received conservative (CT) versus CPAP for 12 weeks. MetS components, homeostasis model assessment...
The changes in shield strategies, treatments, emergence variants, and healthcare pathways might shift the profile outcome of patients hospitalized with COVID-19 successive waves outbreak.
Obstructive sleep apnoea (OSA) seems to worsen metabolism. This effect has not been evaluated in morbid obesity (MO). We hypothesised that the metabolic profile is more impaired MO patients with OSA than those without, and investigated whether any specific dysfunction related MO. A prospective multicentre cross-sectional study was conducted consecutive subjects before bariatric surgery. defined as apnoea/hypopnoea index (AHI) ≥15 by overnight polysomnography. Anthropometrical, blood pressure...
To determine whether an intensive weight-loss program (IWLP) is effective for reducing weight, the severity of obstructive sleep apnea (OSA), and metabolic variables in patients with obesity severe OSA undergoing continuous positive airway pressure treatment.Forty-two were randomized to control (CG, n = 20) or intervention group (IG, 22), who followed a 12-month IWLP. The primary outcome was reduction apnea-hypopnea index (AHI) as measured at 3 12 months by full polysomnography. Metabolic...
There is compelling evidence that obstructive sleep apnoea (OSA) can affect metabolic syndrome (MetS) and cardiovascular risk, but the intermediate mechanisms through which it occurs have not been well defined. We explored impact of OSA in morbidly obese patients with MetS on adipokines, pro-inflammatory markers, endothelial dysfunction, atherosclerosis markers.We included 52 an observational study matched for age, gender central obesity 3 groups (OSA-MetS, Non-OSA-MetS, Non OSA-non-MetS)....
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) signaling is essential in both alveolar macrophages (AMs) differentiation and activation of lung immune cells [1]. Differentiated AMs are crucial the elimination microbes surfactant clearance. The disruption GM-CSF axis leads to development pulmonary proteinosis (PAP) In majority patients this relates presence autoantibodies against autoimmune (a)PAP but there multiple other causes [1, 2, 3]. deficient animals may have impaired...
Abstract Central obesity is the main risk factor for obstructive sleep apnea ( OSA ). Whether there exists a central‐obesity anthropometric that better explains apnea–hypopnea index AHI ) variability in general population and cohorts unknown, this even less explored among increasing grades of obesity. The objective study to investigate whether an sample morbidly obese women awaiting bariatric surgery BS A prospective multicentre cross‐sectional was conducted consecutive before . Demographic...
Summary There is evidence that changes in branched‐chain amino acid ( BCAA ) levels may correlate with the efficacy of therapeutic interventions for affecting improvement metabolic control. The objective this study was to evaluate whether serum concentrations s (leucine, isoleucine, valine) could mediate insulin sensitivity and glucose tolerance after continuous positive airway pressure CPAP treatment patients obstructive sleep apnea OSA ). A prospective randomized controlled trial morbid...
Introduction: Many severe COVID-19 patients require respiratory support and monitoring. An intermediate care unit (IMCU) may be a valuable element for optimizing patient limited health-care resources management. We aim to assess the clinical outcomes of admitted an IMCU. Methods: Observational, retrospective study including IMCU due pneumonia during months March April 2020. Patients were stratified based on their requirement transfer intensive (ICU) survival status at end follow-up. A...
ABSTRACT Introduction On the basis of preliminary report from RECOVERY trial, use dexamethasone or alternative corticosteroids (CS) is currently recommended in severe COVID-19 patients requiring supplemental oxygen. However, last updated recommendations have not taken a position either for against other immunomodulators such as tocilizumab (TCZ), with without CS, since results are still limited. Methods From March 17 to April 7, 2020, real-world observational retrospective analysis was...
COVID-19 has quickly become a global pandemic with substantial number of deaths and is considerable burden for healthcare systems worldwide. Although most cases are paucisymptomatic limited to the viral infection-related symptoms, some patients evolve second phase, an impaired inflammatory response (cytokine storm) that may lead acute respiratory distress syndrome death. This thought be caused by increased bradykinin synthesis.ICAT-COVID multicenter, randomized, open-label, proof-of-concept...
The intermediate respiratory care units (IRCUs) have a pivotal role managing escalation and de-escalation between the general wards intensive (ICUs). Since COVID-19 pandemic began, early detection of patients that could improve on non-invasive therapies (NRTs) in IRCUs without invasive approaches is crucial to ensure proper medical management optimize limiting ICU resources. aim this study was assess factors associated with survival, admission intubation likelihood admitted IRCUs....
<b>Background:</b> Interruption of GM-CSF signaling leads to Pulmonary Alveolar Proteinosis (PAP), occasionally lung infections and relates the impaired ability macrophages catabolize phagocytized surfactant handle microbes. COVID-19 is associated with worse prognosis in disorders. We hypothesized that PAP patients would be at increased risk for poor outcome. Aim objectives: This multi-center, retrospective, European study aimed investigate prevalence clinical consequences impact iGM-CSF...