Antoni Riera‐Mestre
A5010238262- Venous Thromboembolism Diagnosis and Management
- Vascular Anomalies and Treatments
- Atrial Fibrillation Management and Outcomes
- Central Venous Catheters and Hemodialysis
- Tracheal and airway disorders
- COVID-19 Clinical Research Studies
- Vascular Malformations and Hemangiomas
- Diagnosis and Treatment of Venous Diseases
- Sharing Economy and Platforms
- Acute Ischemic Stroke Management
- Acute Myocardial Infarction Research
- Vascular anomalies and interventions
- Pulmonary Hypertension Research and Treatments
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Family and Patient Care in Intensive Care Units
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Effects of Exercise
- Diet and metabolism studies
- Intensive Care Unit Cognitive Disorders
- Cardiac tumors and thrombi
- Pharmacological Effects and Toxicity Studies
- Herpesvirus Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Respiratory viral infections research
Institut d'Investigació Biomédica de Bellvitge
2015-2025
Universitat de Barcelona
2016-2025
Bellvitge University Hospital
2016-2025
Instituto de Salud Carlos III
2024-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2024
Ajuntament de L’Hospitalet
2022
Technical University of Munich
2019
Sociedad Española de Medicina Interna
2018
Universitat Internacional de Catalunya
2014-2016
Hospital Terrassa
2006
The potential role of new oral anticoagulants in antiphospholipid antibody syndrome (APS) remains uncertain.To determine whether rivaroxaban is noninferior to dose-adjusted vitamin K antagonists (VKAs) for thrombotic APS.3-year, open-label, randomized noninferiority trial. (EU Clinical Trials Register: EUDRA [European Union Drug Regulatory Authorities] code 2010-019764-36).6 university hospitals Spain.190 adults (aged 18 75 years) with APS.Rivaroxaban (20 mg/d or 15 mg/d, according renal...
Introduction Loss-of-function TLR7 variants have been recently reported in a small number of males to underlie strong predisposition severe COVID-19. We aimed determine the presence these rare young men with Methods prospectively studied between 18 and 50 years-old without predisposing comorbidities that required at least high-flow nasal oxygen treat The coding region was sequenced assess potentially deleterious variants. Results missense were identified two out 14 patients (14.3%). Overall,...
It is important to predict which patients infected by SARS-CoV-2 are at higher risk of life-threatening COVID-19. Several studies suggest that neutralizing auto-antibodies (auto-Abs) against type I interferons (IFNs) predictive critical COVID-19 pneumonia.We aimed test for auto-Abs IFN and describe the main characteristics admitted intensive care depending on whether or not these present.Retrospective analysis all an unit (ICU) in whom samples were available, from March 2020 2021, Barcelona,...
Summary The pharmacokinetics of oral rivaroxaban are highly predictable and only affected to a limited extent by bodyweight; therefore, dose adjustments for bodyweight not required. However, this raises concerns among physicians potential under- or overdosing. This substudy the randomised EINSTEIN DVT PE trials, which compared with enoxaparin/vitamin K antagonist (VKA) therapy, aimed determine incidence major bleeding in patients low recurrent venous thromboembolism (VTE) high during...
Metabolic syndrome (MetS) is associated with alterations of lipoprotein structure and function that can be characterized advanced testing (ADLT). The effect the Mediterranean diet (MedDiet) weight loss on subclass profile has been scarcely studied. Within PREDIMED-Plus randomized controlled trial, a sub-study conducted at Bellvitge Hospital recruiting center evaluated effects program based an energy-reduced MedDiet (er-MedDiet) physical activity (PA) promotion (intervention group) compared...
Hemorrhagic hereditary telangiectasia (HHT) type 2 patients have increased activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway in telangiectasia. The main objective is to evaluate PI3K cutaneous HHT1 patients. A biopsy a digital hand was performed seven and eight HHT2 compared with six controls. study approved by Clinical Research Ethics Committee our center. histopathological pattern more dilated superficial vessels that pushed up epidermis identified HHT regardless...
Improved prediction of the risk major bleeding in patients with acute pulmonary embolism (
SARS-CoV-2 vaccines' effectiveness is not yet clearly known in immunocompromised patients. This study aims to assess the humoral and cellular specific immune response vaccines predictors of poor patients with common variable immunodeficiency (CVID) phenotype treated B-cell depletion therapies (BCDT), as well safety these vaccines. From March September 2021, we performed a prospective all adult who would receive vaccination were previously diagnosed (i) CVID syndrome (CVID group; n=28) or...
Distinct endothelial cell cycle states (early G1 versus late G1) provide different "windows of opportunity" to enable the differential expression genes that regulate venous arterial specification, respectively. Endothelial control and arteriovenous identities are disrupted in vascular malformations including shunts, hallmark hereditary hemorrhagic telangiectasia (HHT). To date, mechanistic link between regulation development (AVMs) HHT is not known.
Rationale: Patients with acute symptomatic pulmonary embolism (PE) deemed to be at low risk for early complications might candidates partial or complete outpatient treatment.Objectives: To develop and validate a clinical prediction rule that accurately identifies patients PE of short-term compare its prognostic ability two previously validated models (i.e., the Pulmonary Embolism Severity Index [PESI] Simplified PESI [sPESI])Methods: Multivariable logistic regression large international...
Abstract Background Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular disease with autosomal dominant inheritance. Disease-causing variants in endoglin ( ENG ) and activin A receptor type II-like 1 ACVRL1 genes are detected more than 90% of cases submitted to molecular diagnosis. Methods We used data from the RiHHTa (Computerized Registry Hemorrhagic Telangiectasia) registry describe genetic assess their genotype-phenotype correlation among HHT patients Spain. Results By May...
Venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of morbidity mortality worldwide.GARFIELD-VTE prospective, non-interventional observational study real-world treatment practices. We aimed to capture the 36-month clinical outcomes 10,679 patients with objectively confirmed VTE enrolled between May 2014 January 2017 from 415 sites in 28 countries.A total 6582 (61.6 %) had DVT alone, 4097 (38.4 PE ± DVT. At baseline, 98.1...
We aimed to describe risk factors for gastrointestinal (GI) bleeding and endoscopic findings in patients with hereditary hemorrhagic telangiectasia (HHT).This is a prospective study from referral HHT unit. Endoscopic tests were performed when there was suspicion of GI bleeding, divided as follows: with, without, unsuspected involvement.67 (27.9%) 28 (11.7%) 145 (60.4%) involvement included. Age, tobacco use, endoglin (ENG) mutation, hemoglobin associated involvement. Telangiectases mostly...
Abstract Background Gender differences in organ involvement and clinical severity have been poorly described hereditary hemorrhagic telangiectasia (HHT). The aim of this study was to describe the HHT manifestations according gender. Methods Severity measured Epistaxis Score (ESS), Simple Clinical Scoring Index for hepatic involvement, a general HHT-score, needing invasive treatment (pulmonary or brain arteriovenous malformations -AVMs- embolization, liver transplantation Young’s surgery)...
The optimal therapy of patients with acute subsegmental pulmonary embolism (PE) is controversial.