A5031253391- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Occupational exposure and asthma
- Eosinophilic Disorders and Syndromes
- Respiratory and Cough-Related Research
- Systemic Sclerosis and Related Diseases
- Inhalation and Respiratory Drug Delivery
- Signaling Pathways in Disease
- Occupational and environmental lung diseases
- Global Public Health Policies and Epidemiology
- Transplantation: Methods and Outcomes
- Telomeres, Telomerase, and Senescence
- Histiocytic Disorders and Treatments
- Child and Adolescent Health
Sotiria General Hospital
2015-2025
Severe coronavirus disease (COVID-19) is characterized by an excessive proinflammatory cytokine storm, resulting in acute lung injury and development of respiratory distress syndrome (ARDS). The role corticosteroids controversial severe COVID-19 pneumonia associated hyper-inflammatory syndrome. We reported a case series six consecutive patients with pneumonia, ARDS laboratory indices All were treated early short course corticosteroids, clinical outcomes compared before after administration....
Abstract Background and Objective There remains a paucity of large databases for patients with idiopathic pulmonary fibrosis (IPF) lung cancer. We aimed to create European registry. Methods This was multicentre, retrospective study across seven countries between 1 January 2010 18 May 2021. Results identified 324 cancer among 3178 IPF (prevalence = 10.2%). By the end 10 year‐period following diagnosis, 26.6% alive had been diagnosed Patients experienced increased risk all‐cause mortality than...
Background: Hypersensitivity pneumonitis (HP) represents a chronic lung disease with an unpredictable clinical course. There is pressing need for clinically applicable prognostic biomarkers in patients HP. Methods: This was observational, retrospective study. We investigated the potential of complete blood count parameters treatment-naïve diagnosed HP between 15 December 2010 and 1 October 2023. Receiver operating characteristic (ROC) curve analysis identified optimal cut-off thresholds each...
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) signaling is essential in both alveolar macrophages (AMs) differentiation and activation of lung immune cells [1]. Differentiated AMs are crucial the elimination microbes surfactant clearance. The disruption GM-CSF axis leads to development pulmonary proteinosis (PAP) In majority patients this relates presence autoantibodies against autoimmune (a)PAP but there multiple other causes [1, 2, 3]. deficient animals may have impaired...
Background Interstitial lung disease (ILD) is rarer in children (chILD) than adults, but with increasing diagnostic awareness, more cases are being discovered. chILD prognosis often poor, numbers now surviving into adulthood. Aim To characterize chILD-survivors and identify their impact on adult-ILD centers. Methods European study (34 centers) reporting incident/prevalent of from January to July 2023. Epidemiological, clinical, physiological genetic data were collected. Results 244 patients...
Monogenic and polygenic inheritances are evidenced for idiopathic pulmonary fibrosis (IPF). Pathogenic variations in surfactant protein-related genes, telomere-related genes (TRGs), a single-nucleotide polymorphism the promoter of MUC5B gene encoding mucin 5B (rs35705950 T risk allele) reported. This French-Greek collaborative study, Gen-Phen-Re-GreekS inheritable IPF (iIPF), aimed to investigate genetic components patients' characteristics Greek national cohort with suspected...
In childhood, a multitude of causes lead to pulmonary alveolar proteinosis (PAP), an excessive surfactant accumulation in the space, limiting gas exchange. Autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) causing autoimmune PAP, principal aetiology adults, are rare. this first case series on we detail presentation and management issues four children. Whereas three children presented insidiously with progressive dyspnoea, one was acutely sick suspected...
Introduction Diffuse parenchymal lung diseases (DPLD) constitute a heterogeneous group of disorders, sometimes requiring surgical biopsies (SLB) to obtain definite diagnosis. Transbronchial cryobiopsy (TBCB) is new promising interventional bronchoscopic method obtaining tissue that gaining ground against SLB. Methods Fifty consecutive patients with indeterminate DPLD (definite/possible UIP excluded), after expert panel review referral, were retrospectively analyzed from January 2016 August...
Sarcoidosis is an inflammatory granulomatous disease of unknown etiology involving any organ or tissue along with combination active sites, even the most silent ones clinically. The unpredictable nature sites involved in sarcoidosis dictates highly variable natural history and necessity to cluster cases at diagnosis based on clinical and/or imaging common characteristics attempt classify patients their more homogeneous phenotypes, possibly similar behavior, prognosis, outcome, therefore...
OPINION article Front. Pharmacol., 14 April 2022Sec. Experimental Pharmacology and Drug Discovery https://doi.org/10.3389/fphar.2022.836553
Genetic analysis pre-lung transplantation diagnosed a case of hereditary pulmonary alveolar proteinosis (PAP) complicated by fibrosis in adulthood. The need for genetic testing GM-CSF autoantibody negative and unclassifiable PAP is highlighted. https://bit.ly/3QcsYwM.
Objectives In Sarcoidosis joints-muscles-bones (JMBs) localizations are of the least common. 18F-FDG-PET/CT imaging revolutionized detection JMBs involvement by adding metabolic activity information and allowing for a comprehensive, whole-body mapping disease.Aim methods This study investigated prevalence, distribution, clinical significance sarcoidosis in 195 consecutive patients that underwent 18F-FDG PET/CT examination.Results Joint bone were encountered 15% with mean...
<b>Aim and objective:</b> to describe treatment modalities in the Greek cohort of aPAP. <b>Methods:</b> retrospective analysis aPAP patients diagnosed, treated followed-up our department from 2002 2022. <b>Results:</b> Diagnosed are 41(5 lost follow-up, 3/5 with sc-GMCSF). Analyzed 36, 22 (61.1%) females, 21 (58.3%) ever-smokers, median (IQR) age at diagnosis 40.0 (32.5-47.0) years, FVC, DLCO (%predicted) SatO2 80.2 (61.4-96.0), 44.0 (33.0-66.0), 95 (88.0-97.0) [min 52.0-max 98.0]...