A5020683659- Frailty in Older Adults
- Geriatric Care and Nursing Homes
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Syncope and Autonomic Disorders
- Nutrition and Health in Aging
- Dementia and Cognitive Impairment Research
- Obstructive Sleep Apnea Research
- Pharmacogenetics and Drug Metabolism
- Palliative Care and End-of-Life Issues
- Intergenerational Family Dynamics and Caregiving
- Diet and metabolism studies
- Balance, Gait, and Falls Prevention
- Heart Rate Variability and Autonomic Control
- Healthcare Systems and Practices
- Aging, Elder Care, and Social Issues
- Healthcare innovation and challenges
- Primary Care and Health Outcomes
- Migration, Aging, and Tourism Studies
- Obesity and Health Practices
- Chronic Disease Management Strategies
- Nutritional Studies and Diet
- Global Healthcare and Medical Tourism
- Eicosanoids and Hypertension Pharmacology
- Resilience and Mental Health
- Interprofessional Education and Collaboration
St. Vincent's University Hospital
2015-2025
Royal College of Physicians of Ireland
2017-2025
University of Limerick
2025
University College Dublin
2009-2021
Health Service Executive
2020
University Hospital Limerick
2018
St. Columcille's Hospital
2008-2014
Beaumont Hospital
2012
Royal Victoria Infirmary
1996-2002
North Tyneside General Hospital
1998-2000
Objective To determine in humans the relative roles of intestinal and hepatic metabolism oral first-pass elimination a CYP3A substrate using midazolam as model compound. Methods Midazolam was administered intravenously (1 mg) or orally (2 to 20 healthy young subjects (10 men 10 women) random fashion, disposition drug its 1′-hydroxy metabolite were determined. In separate vitro studies, CYP3A-mediated formation 1′-hydroxymidazolam by human microsomes investigated. Results No gender-related...
Chlorzoxazone 6-hydroxylation is mediated by CYP2E1, and its measurement provides an in vivo probe of the enzyme's activity. To determine population distribution such activity, disposition chlorzoxazone 6-hydroxy metabolite was determined after oral administration to 70 white subjects (40 men 30 women) residing middle Tennessee. Both (330 ± 111 ml · min−1, mean SD) fractional (213 86 min−1) clearances varied fourfold fivefold within were unimodally distributed a visually normal fashion....
In vitro studies with human liver microsomes have shown that erythromycin N-demethylation, dapsone N-hydroxylation, and the 6β-hydroxylation of cortisol are all primarily mediated by P4503A4. Trait measurements to assess in vivo level activity these separate oxidations also been developed previously. This study investigated relationships among three phenotypic trait 30 young healthy white men. The frequency distributions values were unimodal, a twofold range for breath test urinary recovery...
High quality, readable health information is vital to mitigate the impact of COVID-19 pandemic. The aim this study was assess quality and readability online using 6 validated tools. This a cross-sectional study. "COVID-19" searched across three most popular English language search engines. Quality evaluated DISCERN score, Journal American Medical Association benchmark criteria Health On Net Foundation Code Conduct. Readability assessed Flesch Reading Ease Score, Flesch-Kincaid Grade Level...
Background Cytochrome P4503A (CYP3A) activity exhibits considerable interindividual variability, and an in vivo probe to measure such differences would serve several purposes. The erythromycin breath test (ERBT) is established approach that has proven useful this regard, but it limitations. More recently, the hydroxylation of midazolam been suggested as alternative approach, because possible estimate CYP3A intestinal epithelium well liver. purpose study was investigate relationship, if any,...
Background: orthostatic hypotension (OH) is a physical sign that reflects final common pathway of various forms disordered physiology, which the hallmark geriatric frailty. Fried et al. recognise three increasing frailty phenotypes in older people, based on measurements weight loss, exhaustion, grip strength, walking speed and activity. Orthostatic haemodynamics have not been considered as markers people.
Abstract Background Although not an inevitable part of ageing, frailty is increasingly common condition in older people. Frail patients are particularly vulnerable to the adverse effects hospitalisation, including deconditioning, immobility and loss independence (Chong et al, J Am Med Dir Assoc 18:638.e7–638.e11, 2017). The ‘Systematic Approach improving care for patients’ (SAFE) study co-designed, with public patient representatives, quality improvement initiatives aimed at enhancing...
Chlorzoxazone's disposition after oral administration was determined in 20 young healthy Caucasian men and a similar group of Japanese men. The drug's plasma concentrations were significantly higher its rate elimination slower compared to Accordingly, chlorzoxazone's clearance smaller (40%) difference (30%) still apparent normalizing for body weight (3.74 +/- 1.23 versus 5.05 1.41 ml.min-1.kg-1, P < .05). This associated with reduced (fractional) by 6-hydroxylation (2.34 1.04 ml.min-1.kg-1...
Few guidelines exist to guide medical personnel on the most successful means of achieving sustained intravenous cannulation. This study examines impact gauge and site cannulas (IC) longevity ICs in hospitalized patients.A prospective was conducted 500 inserted into patients St Vincent's Private hospital from December 2005 June 2006. Patients were followed until IC had been removed or changed. Statistical analysis performed using Cox proportional hazards.Of inserted, 37% 18 g, 46% 20 g 18% 22...
career intentions of medical students may impact on education and workforce planning. We sought to determine (i) choices senior students; (ii) interest in geriatric medicine; (iii) factors influencing such choices; (iv) the a 6-week Medicine Community module.cross-sectional survey all UCD students, before after completion 'Medicine Community' module, 2009-11.eighty-two per cent (274/336) completed at module's end. Two-thirds (174) had chosen future speciality, most frequently general...
Head-up tilt testing is the investigation of choice in diagnosis vasovagal syncope. The test time consuming and labour intensive, with conventional taking up to 45 min. We compared a shortened 'front-loaded' 20-min glyceryl trinitrate-provoked head-up (FLGTN-HUT) standard 40-min passive (HUT) as first line investigations patients unexplained syncope asymptomatic controls. In study, 149 consecutive 83 controls were enrolled. Subjects randomly assigned FLGTN-HUT (800 mcg, metred spray) or HUT,...
Dizziness, syncope, and falls are common occurrences in elderly people. Neurocardiovascular investigation units aim to detect those patients who fall due disturbances of blood pressure control or cardiac conduction. Specialist have a high diagnostic yield the these problems. Does this translate less specialized centers? We report on findings district general hospital neurocardiovascular unit.A total 120 consecutive over age 65 presenting single geriatrician were assessed. After full history...
Background: People with severe obesity (body mass index [BMI] > 40 kg/m2) have an 85% higher mortality than people a healthy BMI. Poor physical function may contribute to this excess mortality. Lymphoedema-like swelling can affect the legs of severely obese normal lymphoscintigraphy. Aim: We sought determine relationship between presence lymphoedema-like and in obese. Design Methods: In obesity, we ascertained whether lower leg was present determined circumference leg, time taken ascend...
Aims An investigation was undertaken to compare the effects of isoniazid pretreatment on CYP2El ‐mediated 6‐hydroxylation chlorzoxazone in healthy subjects known N‐acetylator phenotype. Methods CYP2E1 activity estimated based following single dose (250 mg) oral administration seven slow and eight rapid N‐acetylators who were good health. Separate studies performed prior 14 days after received 300 mg dady. Additional investigations 2 16 discontinuing treatment with antitubercular agent....