A5069355678- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Intensive Care Unit Cognitive Disorders
- Cardiac Structural Anomalies and Repair
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Heart Failure Treatment and Management
- Ultrasound in Clinical Applications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Infective Endocarditis Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Acute Kidney Injury Research
- Anesthesia and Sedative Agents
- Trauma and Emergency Care Studies
- Antibiotics Pharmacokinetics and Efficacy
- Venous Thromboembolism Diagnosis and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Organ Transplantation Techniques and Outcomes
- Viral Infections and Immunology Research
- Renal Transplantation Outcomes and Treatments
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Pitié-Salpêtrière Hospital
2016-2025
Groupe de recherche clinique en anesthésie réanimation médecine périopératoire
2019-2025
Université Paris Cité
2012-2024
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2015-2023
Inserm
2017-2023
Imation (United States)
2015-2023
Hôpital Charles-Foix
2019-2022
FHU Neurovasc
2022
Abstract Managing trauma patients with hemorrhagic shock is complex and difficult. Despite our knowledge of the pathophysiology in that we have accumulated during recent decades, mortality rate these remains high. In acute phase hemorrhage, therapeutic priority to stop bleeding as quickly possible. As long this uncontrolled, physician must maintain oxygen delivery limit tissue hypoxia, inflammation, organ dysfunction. This process involves fluid resuscitation, use vasopressors, blood...
Skeletal muscle has the capacity to adapt environmental changes and regenerate upon injury. To study these processes, most experimental methods use quantification of parameters obtained from images immunostained skeletal muscle. Muscle cross-sectional area, fiber typing, localization nuclei within fiber, number vessels, fiber-associated stem cells are used assess physiology. Manual is time consuming only poorly reproducible. While current state-of-the-art software tools unable analyze all...
The worldwide emergence of multidrug-resistant pathogenic fungi is a threat to human health. At this very moment, an Candida parapsilosis isolates harbouring resistance fluconazole, one the most popular antifungal drugs, being described in several countries. We seek better understanding epidemiology, pathogenicity and transmission resistant Faced with outbreak invasive infections due C. parapsilosis, we performed 7-year retrospective prospective analysis 283 collected 240 patients, among who...
The optimal approach to the use of venoarterial extracorporeal membrane oxygenation (ECMO) during cardiogenic shock is uncertain.To determine whether early moderate hypothermia (33-34 °C) compared with strict normothermia (36-37 improves mortality in patients receiving ECMO.Randomized clinical trial (who were eligible if they had been endotracheally intubated and ECMO for <6 hours) conducted intensive care units at 20 French cardiac centers between October 2016 July 2019. Of 786 patients,...
Abstract Background After cardiac surgery, post-operative delirium (PoD) is acknowledged to have a significant negative impact on patient outcome. To date, there no valuable and specific treatment for PoD. Critically ill patients often suffer from poor sleep condition. There an association between quality after surgery. This study aimed establish whether promoting using overnight infusion of dexmedetomidine reduces the incidence Methods Randomized, pragmatic, multicentre, double-blind,...
Cardiac surgery associated acute kidney injury (CSA-AKI) is a frequent and severe complication. Goal Directed Perfusion (GDP) during cardiopulmonary bypass (CPB) has been developed to reduce post-operative complications, in particular CSA-AKI. Hence, we aimed assess the implementation of GDP strategy CPB on incidence CSA-AKI large, unselected cardiac population. We conducted retrospective, before after study, including all patients admitted our surgical intensive care unit (ICU) following...
Community-acquired pneumonia (CAP) account for a high proportion of ICU admissions, with Streptococcus pneumoniae being the main pathogen responsible these infections. However, little is known on clinical features and outcomes patients pneumococcal pneumonia. The aims this study were to provide epidemiological data determine risk factors mortality in admitted severe S. CAP.We performed retrospective review two prospectively-acquired multicentre databases (2001-2008). Patients management CAP...
Abstract Background There is little descriptive data on Stenotrophomonas maltophilia hospital-acquired pneumonia (HAP) in critically ill patients. The optimal modalities of antimicrobial therapy remain to be determined. Our objective was describe the epidemiology and prognostic factors associated with S. pneumonia, focusing therapy. Methods This nationwide retrospective study included all patients admitted 25 French mixed intensive care units between 2012 2017 HAP during unit stay. Primary...
Introduction Ventilator-associated pneumonia (VAP) is frequent in Intensive Care Unit (ICU) patients. In the specific case of patients treated with Veno-Arterial Extracorporeal Membrane Oxygenation Support (VA-ECMO), VAP treatment failures (VAP-TF) have been incompletely investigated. Methods To investigate risk factors failure a large cohort ICU VA-ECMO, we conducted retrospective study Surgical about assisted VA-ECMO between January 1, 2013, and December 31, 2014. Diagnosis was confirmed...
Abstract Background Nebulisation of antibiotics is a promising treatment for ventilator-associated pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic concentrations at the site infection in interstitial space fluid crucial clinical outcomes. Current assessment methods, such as epithelial lining and tissue homogenates, have limitations providing longitudinal pharmacokinetic data. Main body Lung microdialysis, an invasive research technique predominantly...
Heart transplantation in patients supported by venoarterial extracorporeal membrane oxygenation has been associated with poor prognosis. A specific protocol for management encompassing patient selection, implantation strategy, and preoperative perioperative treatment is applied at our institution. Our aim was to compare posttransplant outcomes of or not the time heart transplantation.
Abstract Background The optimal treatment duration and the nature of regimen antibiotics (monotherapy or combination therapy) for Pseudomonas aeruginosa ventilator‑associated pneumonia (PA-VAP) remain debated. aim this study was to evaluate whether a antibiotic therapy is superior monotherapy in patients with PA-VAP terms reduction recurrence death, based on 186 included iDIAPASON trial, multicenter, randomized controlled trial comparing 8 versus 15 days PA-VAP. Methods Patients...