A5002563127- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Metabolomics and Mass Spectrometry Studies
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Transplantation: Methods and Outcomes
- Airway Management and Intubation Techniques
- Central Venous Catheters and Hemodialysis
- Erythropoietin and Anemia Treatment
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Iron Metabolism and Disorders
- Hemodynamic Monitoring and Therapy
- Cardiac Ischemia and Reperfusion
- Neurological Complications and Syndromes
- Infrared Thermography in Medicine
- Antimicrobial Resistance in Staphylococcus
- Metabolism and Genetic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Procedures and Complications
- Anesthesia and Neurotoxicity Research
- Acute Ischemic Stroke Management
Centre Hospitalier Universitaire de Poitiers
2016-2025
Inserm
2014-2025
Ischémie Reperfusion, Métabolisme et Inflammation Stérile en Transplantation
2023-2024
Université de Poitiers
2014-2023
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2018-2023
Imation (United States)
2016-2022
Opera Software (Ireland)
2022
Hopitaux Civils de Colmar
2019
Pharmac
2018
methodS in Patient-centered outcomes and HEalth ResEarch
2018
Before surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme or angiotensin receptor blockers) is unknown. The lack of evidence leads to conflicting guidelines.
The brain-based determination of death ("brain death") is now widely accepted throughout the world. It states that irreversible cessation brain functions fundamental criterion for human death. recent World Brain Death Project provided a comprehensive cataloguing all aspects including its medical and legal acceptance world.1 Organ donation after (DBDD) currently accounts majority multiorgan donations internationally. circulatory (DCDD) has grown worldwide since Institute Medicine United...
Abstract Background After cardiac surgery, post-operative delirium (PoD) is acknowledged to have a significant negative impact on patient outcome. To date, there no valuable and specific treatment for PoD. Critically ill patients often suffer from poor sleep condition. There an association between quality after surgery. This study aimed establish whether promoting using overnight infusion of dexmedetomidine reduces the incidence Methods Randomized, pragmatic, multicentre, double-blind,...
Objective: Recent preclinical and clinical data suggest that thoracic epidural analgesia, a technique primarily aimed at decreasing pain, might exert anti-inflammatory effects, enhance splanchnic pancreatic blood flow during acute pancreatitis; however, the influence of analgesia on mortality remains under investigated in this setting. This study was therefore designed to assess impact ICU patients with pancreatitis. Design: Multicenter retrospective, observational, cohort study. Setting:...
Kidneys from donation after circulatory death (DCD) are highly sensitive to ischemia-reperfusion injury and thus require careful reconditioning, such as normothermic regional perfusion (NRP). However, the optimal NRP protocol remains be characterized. was modeled in a DCD porcine model (30 minutes of cardiac arrest) for 2, 4, or 6 hours compared control group (No-NRP); kidneys were machine-preserved allotransplanted. appeared permit recovery warm ischemia, possibly due an increased...
Abstract Background Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), difficult to diagnose the context of inflammation. Hepcidin new marker ID. We aimed assess whether hepcidin levels would accurately guide treatment ID critically ill anemic after prolonged ICU stay and affect post-ICU outcomes. Methods In controlled, single-blinded, multicenter study, (WHO definition) with an ≥ 5 days were randomized when discharge was expected either...
Continuous monitoring of core temperature is essential during major surgery as a way improving patient safety. Oesophageal probes or specific arterial catheters are invasive methods used in this setting. A new noninvasive device based on zero-heat-flux (ZHF) technique (SpotOn) seems promising but has been poorly investigated rapid changes (RCTC).To assess the accuracy SpotOn sensor vs. an oesophageal probe catheter slow change less than 1 °C within 30 min and RCTC ≥ min.Prospective...
The eIF5A hypusination inhibitor GC7 (N1-guanyl-1,7-diaminoheptane) was shown to protect from ischemic injuries. We hypothesized that could be useful for preconditioning kidneys donors before transplantation. Using a preclinical porcine brain death (BD) donation model, we carried out in vivo evaluation of pretreatment (3 mg/kg iv, 5 minutes after BD) at the beginning 4h-donor management, which were collected and cold-stored (18h University Wisconsin solution) 1 allotransplanted. Groups...
Background Connected devices are dramatically changing many aspects in health care. One such device, the virtual reality (VR) headset, has recently been shown to improve analgesia a small sample of patients undergoing transcatheter aortic valve implantation. Objective We aimed investigate feasibility and effectiveness VR atrial fibrillation (AF) ablation under conscious sedation. Methods All who underwent an AF with from March May 2020 were included. Patients compared consecutive cohort 3...
Recently, the pig liver model perfused ex vivo using a normothermic machine perfusion (NMP) has been proposed as suitable to study xenobiotic metabolism and biliary excretion. The aim of our is describe NPS such cathinones (with focus on 4-Cl-PVP eutylone) in blood bile, model. Livers (n = 4) from male large white pigs, 3-4 months age weighing approximately 75-80 kg, were harvested reperfused onto an NMP (LiverAssist®, XVIVO) autologous whole at 38 °C. eutylone administered bolus circulating...
Objectives: To compare accuracy of a continuous noninvasive cutaneous temperature using zero-heat-flux method to esophageal and arterial temperature. Design: Prospective study. Setting: ICU NeuroICU, University Hospital. Patients: Fifty-two patients over 4-month period who required monitoring were included in the study, after informed consent. Interventions: All had probe device monitor their core continuously. In seven cardiac output monitoring, iliac was collected. Simultaneous...
Conflicting results have been reported on the influence of Polymyxin-B hemoperfusion treatment systemic inflammation markers. The aim study was to assess in a randomized control trial plasma cytokine concentrations septic shock due peritonitis. A panel 10 pro- or anti-inflammatory cytokines measured 213 patients with peritonitis-induced enrolled ABDOMIX testing impact 2 sessions standard treatment. Gram-negative bacteria were identified 69% patients. In overall population, baseline not...
Introduction Hypoxaemia and hyperoxaemia may occur after surgery, with related complications. This multicentre randomised trial evaluated the impact of automated closed-loop oxygen administration high-risk abdominal or thoracic surgeries in terms optimising saturation measured by pulse oximetry time within target range. Methods After extubation, patients an intermediate to high risk post-operative pulmonary complications were “standard” “automated” administration. The primary outcome was...
Controlled donation after circulatory death (cDCD) is used for "extended criteria" donors with poorer kidney transplant outcomes. The French cDCD program started in 2015 and characterized by normothermic regional perfusion, hypothermic machine short cold ischemia time. We compared the outcomes of transplantation from brain-dead (DBD) donors, matching DBD transplants propensity scoring donor recipient characteristics. process retained 442 499 809 6185 transplantations. DGF rate was 20%...