A5017490302- Dermatology and Skin Diseases
- Wound Healing and Treatments
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Tendon Structure and Treatment
- Autoimmune and Inflammatory Disorders Research
- Skin and Cellular Biology Research
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Autoimmune Bullous Skin Diseases
- Cytomegalovirus and herpesvirus research
- Mast cells and histamine
- Sepsis Diagnosis and Treatment
- Whipple's Disease and Interleukins
- melanin and skin pigmentation
- Mosquito-borne diseases and control
- Olfactory and Sensory Function Studies
- Dermatologic Treatments and Research
- Systemic Sclerosis and Related Diseases
- HIV Research and Treatment
- Pneumonia and Respiratory Infections
- Multiple Sclerosis Research Studies
- Immunodeficiency and Autoimmune Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacterial Infections and Vaccines
Université de Poitiers
2012-2024
Centre Hospitalier Universitaire de Poitiers
2009-2020
Université Paris Cité
2016
Université de Tours
2016
Université de Rouen Normandie
2016
Centre Hospitalier Universitaire de Tours
2016
Inserm
2016
Université de Bordeaux
2016
Dengue virus (DENV), a mosquito-borne flavivirus, is public health problem in many tropical countries. IL-22 and IL-17A are key cytokines several infectious inflammatory diseases. We have assessed the contribution of pathogenesis experimental dengue infection using mouse-adapted DENV serotype 2 strain (P23085) that causes disease resembles severe humans. show produced upon DENV-2 immune-competent mice. Infected IL-22(-/-) mice had increased lethality, neutrophil accumulation pro-inflammatory...
Although the presence of pathogens in skin wounds is known to delay wound healing process, mechanisms underlying this remain poorly understood. In present study, we have investigated regulatory role proinflammatory cytokines on kinetics infected wounds.We developed a mouse model cutaneous healing, with or without inoculation Staphylococcus aureus and Pseudomonas aeruginosa, two major involved bacterial infections.Aseptic excision C57BL/6 induced early expression IL-1β, TNFα Oncostatin M...
Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to heterodimeric receptor consisting IL-22 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, plays an essential role in number inflammatory diseases. Recently, functional detected cancer cells such as hepatocarcinoma lung carcinoma, but its presence not reported glioblastoma (GBM). Two GBM cell lines 10 primary established from patients undergoing surgery for malignant were...
Conflicting results have been reported on the influence of Polymyxin-B hemoperfusion treatment systemic inflammation markers. The aim study was to assess in a randomized control trial plasma cytokine concentrations septic shock due peritonitis. A panel 10 pro- or anti-inflammatory cytokines measured 213 patients with peritonitis-induced enrolled ABDOMIX testing impact 2 sessions standard treatment. Gram-negative bacteria were identified 69% patients. In overall population, baseline not...
Abstract Wound healing is a complex physiological process that repairs skin lesion and produces fibrous tissue. In some cases, this can lead to hypertrophic scars (HS) or keloid (KS), for which the pathophysiology remains poorly understood. Previous studies have reported presence of oncostatin M (OSM) during wound process; however, role OSM in pathological scarring be precisely elucidated. This study aims analyse involvement process. It was conducted with 18 patients, including 9 patients...
IL-1 plays a crucial role in triggering sterile inflammation following tissue injury. Although most studies associate release by injured cells to the recruitment of neutrophils for repair, inflammatory cascade involves several molecular and cellular actors whose remains be specified. In present study, we identified dermal fibroblasts among IL-1R1-expressing skin as key sensors released keratinocytes. After vitro stimulation recombinant cytokines or protein extracts lysed keratinocytes...
Background Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever monoclonal IgM gammopathy. Overactivation of the interleukin(IL)-1 system reported, even though exact pathophysiological pathways remain unknown. Objective To determine ex v ivo cytokine profiles Peripheral Blood Mononuclear Cells (PBMCs) from SchS patients prior to treatment after initiation anti-IL-1 therapy (anakinra). The sera profile was...
Abstract Mainly known for its role in immune defense and inflammation, interleukin 22 (IL-22) has emerged over the past decade as a cytokine involved adaptation of stem/progenitor cell activity tissue homeostasis repair. IL-22 is present brain, which harbors neural stem cells (NSC) specific niches ventricular-subventricular zone (V-SVZ) most important. In this study, we examined possible effect on NSC adult mouse brain. We demonstrate that receptor expressed V-SVZ, mainly characterized by...
With the support of a ministerial program for innovative and expensive technologies, dedicated to economic evaluation laboratory diagnosis pertussis by real-time PCR, external quality assessment IS481 PCR was carried out. Coordinated National Centre Reference Pertussis other Bordetelloses (NCR), this study aimed harmonize assess performances eight participating microbiology hospital laboratories throughout French territory. Between January 2006 February 2007, 10 proficiency panels were sent...