A5067692511- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Cardiac electrophysiology and arrhythmias
- Anesthesia and Pain Management
- Trauma and Emergency Care Studies
- Non-Invasive Vital Sign Monitoring
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Intensive Care Unit Cognitive Disorders
- Acute Ischemic Stroke Management
- Blood Pressure and Hypertension Studies
- Acute Kidney Injury Research
- Nitric Oxide and Endothelin Effects
- Cardiac pacing and defibrillation studies
- Cardiovascular Health and Disease Prevention
- Health, Medicine and Society
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
Université de Caen Normandie
2016-2025
Centre Hospitalier Universitaire de Caen Normandie
2015-2024
Normandie Université
2013-2024
Cyceron
2014-2024
Inserm
1998-2024
Physiopathologie et imagerie des troubles neurologiques
2021-2024
Centre Hospitalier Universitaire de Reims
2021-2022
Hôpitaux Universitaires de Strasbourg
2022
Hôpitaux Universitaires Henri-Mondor
2022
Aix-Marseille Université
2022
The aim of the present study was to investigate impact different stroke subtypes on glymphatic system using MRI.We first improved and characterized an in vivo protocol measure perfusion MRI after minimally invasive injection a gadolinium chelate within cisterna magna. Then, integrity evaluated 4 models mice including subarachnoid hemorrhage (SAH), intracerebral hemorrhage, carotid ligature, embolic ischemic stroke.We were able reliably evaluate function MRI. Moreover, we provided evidence...
Objective: To compare dialysis catheter function according to site. Design: Multicenter, open, randomized controlled trial. Setting: Nine university-affiliated hospitals and three general in France. Patients: Seven hundred thirty-six patients intensive care units who required a first venous catheterization perform either intermittent hemodialysis (470 with 1275 sessions) or continuous renal replacement therapy (266 1003 days). Intervention: Patients randomly received femoral (n = 370)...
Catecholamines, mainly dobutamine, are often administered without institutional guidelines or prespecified algorithms in cardiac surgery. The current study assessed the consequences on clinical outcome of catecholamines simply based judgment anesthesiologists after cardiopulmonary bypass adult surgery.Consecutive patients were enrolled a nonrandomized cohort study. Factors associated with perioperative use and outcomes recorded prospectively to conduct bias adjustment, including propensity...
Abstract Background Trauma-induced coagulopathy includes thrombocytopenia and platelet dysfunction that impact patient outcome. Nevertheless, the role of transfusion remains poorly defined. The aim study was 1/ to evaluate early on 24-h all-cause mortality 2/ describe count at admission (PCA) its relationship with trauma severity Methods Observational carried out a multicentre prospective registry. All adult patients directly admitted in participating centres between May 2011 June 2019 were...
Electric scooter (e-scooter) use is increasing in France and many urban environments worldwide. Yet little known about injuries associated with of e-scooters.
Background The authors examined the role of adenosine triphosphate-sensitive potassium (K(ATP)) channels, A1 receptor, and alpha beta adrenoceptors in desflurane-induced preconditioning human myocardium, vitro. Methods recorded isometric contraction right atrial trabeculae suspended oxygenated Tyrode's solution (34 degrees C; stimulation frequency, 1 Hz). Before a 30-min anoxic period, 3, 6, 9% desflurane was administered during 15 min. Desflurane, 6%, also presence 10 microm glibenclamide,...
Benefits and limitations of supplementation with 80% fraction inspired oxygen for preventing surgical site infections have not yet been clearly defined. Some studies reported benefits in colorectal surgery, whereas trials abdominal gynecologic surgery either no effect or a deleterious effect.Controlled, randomized, assessor-blind multicenter trial, the ISO2 study, comparing effects hyperoxygenation (fraction oxygen, 80%) those 30% on frequency routine abdominal, gynecologic, breast 434...
The WhatsApp smartphone app is the most widely used instant messaging in world. Recent studies reported use of for educational purposes, but there no prospective study comparing WhatsApp's pedagogical effectiveness to that any other teaching modality.The main objective this was measure impact a learning program via on clinical reasoning medical residents.This prospective, randomized, multicenter conducted among first- and second-year anesthesiology residents (offline recruitment) from four...
Although phenylephrine is widely used in the operating room to control arterial pressure, its haemodynamic effects remain controversial.We hypothesised that effect of on cardiac output affected by preload dependency.A prospective observational study.Single-centre, University Hospital Caen, France.Fifty ventilated patients undergoing surgery were studied during hypotension before and after administration phenylephrine.Cardiac index (CI), stroke volume (SV), corrected flow time, mean pulse...
Background The N exfin device uses non‐invasive photoplethysmography to monitor cardiac output and respiratory variations in pulse pressure stroke volume. aim of this study was compare rapid changes index after fluid challenge between bolus transpulmonary thermodilution the ability predict responsiveness dynamic indices given by exfin. Methods Simultaneous comparative were collected from before 45 patients following conventional surgery. Correlations, B land– A ltman analyses percentage...
Abstract Background Ischemic myocardial damage accompanying coronary artery bypass graft surgery remains a clinical challenge. We investigated whether xenon anesthesia could limit in patients, as has been reported for animal ischemia models. Methods In 17 university hospitals France, Germany, Italy, and The Netherlands, low-risk elective, on-pump patients were randomized to receive xenon, sevoflurane, or propofol-based total intravenous maintenance. primary outcome was the cardiac troponin I...
There is recent evidence to show that patients suffering from acute kidney injury are at increased risk of developing chronic disease despite the fact surviving tubular epithelial cells have capacity fully regenerate renal tubules and restore function within days or weeks. The aim study was investigate impact on de novo disease.The authors conducted a retrospective population-based cohort initially free who were scheduled for elective cardiac surgery with cardiopulmonary bypass developed an...
To describe the characteristics, management, and outcome of patients admitted to ICUs for pheochromocytoma crisis.A 16-year multicenter retrospective study.Fifteen university nonuniversity in France.Patients ICU crisis.None.We included 34 with a median age 46 years (40-54 yr); 65% were males. At admission, Sequential Organ Failure Assessment score was 8 (4-12) Simplified Acute Physiology Score II 49.5 (27-70). The left ventricular ejection fraction consistently decreased value 30% (15-40%)....