A5007115589- Acute Kidney Injury Research
- Respiratory Support and Mechanisms
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Family and Patient Care in Intensive Care Units
- Intensive Care Unit Cognitive Disorders
- Renal function and acid-base balance
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Central Venous Catheters and Hemodialysis
- Palliative Care and End-of-Life Issues
- Airway Management and Intubation Techniques
- Antibiotics Pharmacokinetics and Efficacy
- Healthcare Decision-Making and Restraints
- Innovations in Medical Education
- Pneumonia and Respiratory Infections
- Electrolyte and hormonal disorders
- Urinary Tract Infections Management
- Complement system in diseases
- Hematological disorders and diagnostics
- Metabolism and Genetic Disorders
- Advanced Glycation End Products research
Centre Hospitalier Universitaire de Clermont-Ferrand
2015-2024
Centre Jean Perrin
2019-2024
Laboratoire Microorganismes Génome et Environnement
2016-2023
Centre National de la Recherche Scientifique
2017-2023
Université Clermont Auvergne
2014-2023
Inserm
2005-2022
Centre Hospitalier Universitaire de Rennes
2022
Centre Hospitalier Universitaire de Nantes
2022
Université de Poitiers
2022
Authorised Association Consortium
2021
The timing of renal-replacement therapy in critically ill patients who have acute kidney injury but no potentially life-threatening complication directly related to renal failure is a subject debate.
<h3>Importance</h3> High-flow nasal oxygen may prevent postextubation respiratory failure in the intensive care unit (ICU). The combination of high-flow with noninvasive ventilation (NIV) be an optimal strategy to avoid reintubation. <h3>Objective</h3> To determine whether prophylactic NIV applied immediately after extubation could reduce rate reintubation, compared alone, patients at high risk ICU. <h3>Design, Setting, and Participants</h3> Multicenter randomized clinical trial conducted...
Spontaneous-breathing trials can be performed with the use of either pressure-support ventilation (PSV) or a T-piece. Whether PSV may result in shorter time to tracheal extubation than T-piece trials, without resulting higher risk reintubation, among patients who have high failure is unknown.In this multicenter, open-label trial, we randomly assigned had (i.e., were >65 years age an underlying chronic cardiac respiratory disease) undergo spontaneous-breathing (with level 8 cm water and no...
To determine the prevalence and risk factors of symptoms anxiety, depression, posttraumatic stress disorder-related in patients with chronic obstructive pulmonary disease their relatives after an intensive care unit stay.Prospective multicenter study.Nineteen French units.One hundred twenty-six who survived stay 102 relatives.None.Patients were interviewed at discharge 90 days later to assess anxiety depression using Hospital Anxiety Depression Scale (HADS) Impact Event (IES). At discharge,...
<h3>Importance</h3> Keeping a diary for patients while they are in the intensive care unit (ICU) might reduce their posttraumatic stress disorder (PTSD) symptoms. <h3>Objectives</h3> To assess effect of an ICU on psychological consequences hospitalization. <h3>Design, Setting, and Participants</h3> Assessor-blinded, multicenter, randomized clinical trial 35 French ICUs from October 2015 to January 2017, with follow-up until July 2017. Among 2631 approached patients, 709 adult (with 1 family...
Objective: To compare dialysis catheter function according to site. Design: Multicenter, open, randomized controlled trial. Setting: Nine university-affiliated hospitals and three general in France. Patients: Seven hundred thirty-six patients intensive care units who required a first venous catheterization perform either intermittent hemodialysis (470 with 1275 sessions) or continuous renal replacement therapy (266 1003 days). Intervention: Patients randomly received femoral (n = 370)...
To assess the prognostic impact of transient and persistent acute kidney injury in critically ill patients.Retrospective analysis prospectively collected patient data: Six hospital ICUs.Critically-ill patients with ICU stay longer than three days.None.Assessment survival respect to duration. A total 447 were included this study, including 283 (63.3%) an at admission (175 108 injury, respectively). Patients more frequently had stage 3 (42.9% vs 30.6%; p = 0.04). Hospital was 76.2% (n 125)...
In this study, we aimed to assess the association between acute kidney injury (AKI) and mortality in critically ill patients using an original competing risks approach. Unselected admitted 1997 2009 13 French medical or surgical intensive care units were included observational cohort study. AKI was defined according RIFLE criteria. The following data recorded: baseline characteristics, daily serum creatinine level, Sequential Organ Failure Assessment (SOFA) score, vital status at hospital...
Detecting impaired glomerular filtration rate (GFR) is important in intensive care units (ICU) order to diagnose acute kidney injuries and adjust the dose of renally excreted drugs. Whether serum Cystatin C (SCysC) may better reflect than creatinine (SCr) context medicine uncertain. We compared performance SCysC SCr as biomarkers GFR 47 critically ill patients (median SOFA (Sepsis-related Organ Failure Assessment) score 5) for whom was measured by a reference method (urinary clearance...
The optimal strategy for initiation of renal replacement therapy (RRT) in patients with severe acute kidney injury the context septic shock and respiratory distress syndrome (ARDS) is unknown.To examine effect an early compared a delayed RRT on 60-day mortality according to baseline sepsis status, ARDS severity.Post hoc analysis AKIKI (Artificial Kidney Initiation Injury) trial.Subgroups were defined characteristics: status (Sepsis-3 definition), (Berlin Simplified Acute Physiology Score 3...
Abstract Acute respiratory distress syndrome (ARDS) prediction remains challenging despite available clinical scores. To assess soluble receptor for advanced glycation end-products (sRAGE), a marker of lung epithelial injury, as predictor ARDS in high-risk population, adult patients with at least one risk factor upon admission to participating intensive care units (ICUs) were enrolled multicentre, prospective study between June 2014 and January 2015. Plasma sRAGE endogenous secretory RAGE...
Rationale: Although noninvasive ventilation (NIV) may prevent reintubation in patients at high risk of extubation failure ICUs, this oxygenation strategy has not been specifically assessed obese patients. Objectives: We hypothesized that NIV decrease the compared with high-flow nasal oxygen. Methods:Post hoc analysis a multicenter randomized controlled trial (not prespecified) comparing alternating oxygen versus alone after extubation, aim assessing effects according to patient body mass...
<h3>Importance</h3> Current guidelines recommend brain magnetic resonance imaging (MRI) for clinical management of patients with severe herpes simplex encephalitis (HSE). However, the prognostic value has not been demonstrated in this setting. <h3>Objective</h3> To investigate association between early MRI data and functional outcomes HSE at 90 days after intensive care unit (ICU) admission. <h3>Design, Setting, Participants</h3> This multicenter cohort study was conducted 34 ICUs France...
Abstract Introduction Urinary indices have limited effectiveness in separating transient acute kidneyinjury (AKI) from persistent AKI ICU patients. Their time-course may vary withthe mechanism of AKI. The primary objective this study was to evaluate thediagnostic value changes over time the usual urinary separatingtransient Methods An observational prospective multicenter performed six ICUs involving244 consecutive patients, including 97 without AKI, 54 with and 93with sodium, urea...
Abstract Introduction Although renal replacement therapy (RRT) is a common procedure in critically ill patients with acute kidney injury (AKI), its efficacy remains uncertain. Patients who receive RRT usually have higher mortality rates than those do not. However, many differences exist severity patterns between and without available results are further confounded by treatment selection bias since no consensus on indications for has been reached so far. Our aim was to account these biases...
The extent of the consequences an episode severe acute kidney injury (AKI) on long-term outcome critically ill patients remain debated. We conducted a prospective follow-up included in large multicenter clinical trial renal replacement therapy (RRT) initiation strategy during AKI (the Artificial Kidney Initiation Injury, AKIKI) to investigate survival, and health related quality life (HRQOL). also assessed influence RRT these outcomes.Follow-up extended from 60 days median 3.35 years...
Abstract Background There are no easily available markers of renal recovery to guide intermittent hemodialysis (IHD) weaning. The aim this study was identify for IHD weaning in critically ill patients with acute kidney injury (AKI). Methods We performed a retrospective single-center cohort treated at least 7 days and four dialysis sessions AKI between 2006 2011 an intensive care unit (ICU) French university hospital. Blood urinary were recorded on the day last ICU unweaned 2 after weaned...