Alexandre Robert
A5063486392- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- COVID-19 Impact on Reproduction
- Infectious Encephalopathies and Encephalitis
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Cassava research and cyanide
- Invertebrate Immune Response Mechanisms
- Bacterial Identification and Susceptibility Testing
- Herpesvirus Infections and Treatments
- Intensive Care Unit Cognitive Disorders
- Peripheral Neuropathies and Disorders
- Food Safety and Hygiene
- Cardiac and Coronary Surgery Techniques
- Artificial Intelligence in Healthcare and Education
- Sphingolipid Metabolism and Signaling
- Vibrio bacteria research studies
- Maternal and fetal healthcare
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Cardiac Arrest and Resuscitation
- Facial Nerve Paralysis Treatment and Research
- Autoimmune Neurological Disorders and Treatments
Centre Hospitalier Universitaire de Nice
2015-2024
Hôpital Pasteur
2024
ICU Medical (United States)
2024
Centre Hospitalier de Cannes
2021-2023
Inserm
2018-2023
Université Côte d'Azur
2015-2023
Centre Méditerranéen de Médecine Moléculaire
2020-2023
Authorised Association Consortium
2021
Sorbonne Université
2018
Hôpital Charles-Foix
2018
Abstract Dysregulated immune response is the key factor leading to unfavorable coronavirus disease 2019 (COVID-19) outcome. Depending on pathogen-associated molecular pattern, NLRP3 inflammasome can play a crucial role during innate immunity activation. To date, studies describing severe acute respiratory syndrome 2 infection in patients are lacking. We prospectively monitored caspase-1 activation levels peripheral myeloid cells from healthy donors and with mild critical COVID-19. The...
<h3>Importance</h3> Current guidelines recommend brain magnetic resonance imaging (MRI) for clinical management of patients with severe herpes simplex encephalitis (HSE). However, the prognostic value has not been demonstrated in this setting. <h3>Objective</h3> To investigate association between early MRI data and functional outcomes HSE at 90 days after intensive care unit (ICU) admission. <h3>Design, Setting, Participants</h3> This multicenter cohort study was conducted 34 ICUs France...
Given the high risk of thrombosis and anticoagulation-related bleeding in patients with hypoxemic COVID-19 pneumonia, identifying lowest effective dose anticoagulation therapy for these is imperative.To determine whether therapeutic (TA) or high-dose prophylactic (HD-PA) decreases mortality and/or disease duration compared standard-dose (SD-PA), TA outperforms HD-PA; to compare net clinical outcomes among 3 strategies.The ANTICOVID randomized open-label trial included pneumonia requiring...
No recommendation exists about the timing and setting for tracheal intubation mechanical ventilation in septic shock.This prospective multicenter observational study was conducted 30 ICUs France Spain. All consecutive patients presenting with shock were eligible. The use of described across participating ICUs. A multivariate analysis performed to identify parameters associated early (before H8 following vasopressor onset).Eight hundred fifty-nine enrolled. Two nine intubated (24%, range...
Pneumonia is one of the major complications drowning, but optimal empirical antibiotic treatment not clearly defined. Multidrug-resistant (MDR) bacteria and fungi have been identified in a recent series freshwater drowning-associated pneumonia. However, microbial data seawater drowning are scarce. The objective study to describe microorganisms isolated early respiratory specimens obtained from pneumonia provide their susceptibility pattern.All patients admitted for between 2003 2013 two...
Abstract Background Electroencephalography (EEG) is recommended for the practical approach to diagnosis and prognosis of encephalitis. We aimed investigate prognostic value standard EEG ( std EEG) in adult patients with severe herpes simplex Methods performed a retrospective analysis consecutive ICU encephalitis 38 French centers between 2006 2016. Patients at least one study admission were included. findings reviewed independently by two investigators. The association (i.e., background...
Polymicrobial infections are complex associated with worse outcomes compared to monomicrobial infections. We need simple, fast, and cost-effective animal models assess their still poorly known pathogenesis.We developed a Drosophila melanogaster polymicrobial infection model for opportunistic pathogens assessed its capacity discriminate the effects of bacterial mixtures taken from cases human by Aeromonas strains. A systemic was obtained needle pricking dorsal thorax flies, fly survival...
Introduction COVID-19 induces venous, arterial and microvascular thrombosis, involving several pathophysiological processes. In patients with severe without macrovascular escalating into high-dose prophylactic anticoagulation (HD-PA) or therapeutic (TA) could be beneficial in limiting the extension of thrombosis forestalling evolution lung multiorgan microcirculatory dysfunction. absence data from randomised trials, clinical practice varies widely. Methods analysis This is a French...
Fever treatment is commonly applied in patients with sepsis but its impact on survival remains undetermined. Patients respiratory and haemodynamic failure are at the highest risk for not tolerating metabolic cost of fever. However, fever can help to control infection. Treating paracetamol has been shown be less effective than cooling. In SEPSISCOOL pilot study, active by external cooling improved organ recovery early survival. The main objective this confirmatory trial assess whether...