A5026194626- Cervical Cancer and HPV Research
- Inflammasome and immune disorders
- Genital Health and Disease
- Molecular Biology Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Myasthenia Gravis and Thymoma
- Ubiquitin and proteasome pathways
- COVID-19 Clinical Research Studies
- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Insects and Parasite Interactions
- Blood disorders and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Immunodeficiency and Autoimmune Disorders
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Head and Neck Anomalies
- Cancer-related Molecular Pathways
- Streptococcal Infections and Treatments
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- COVID-19 Impact on Reproduction
Université Côte d'Azur
2011-2025
Inserm
2009-2025
Centre Méditerranéen de Médecine Moléculaire
2011-2021
Centre Hospitalier Universitaire de Nice
2017-2018
Hôpital l'Archet
2017
Hôpital Pasteur
2009
Abstract Dysregulated immune response is the key factor leading to unfavorable coronavirus disease 2019 (COVID-19) outcome. Depending on pathogen-associated molecular pattern, NLRP3 inflammasome can play a crucial role during innate immunity activation. To date, studies describing severe acute respiratory syndrome 2 infection in patients are lacking. We prospectively monitored caspase-1 activation levels peripheral myeloid cells from healthy donors and with mild critical COVID-19. The...
Transcription factor EB (TFEB) is a key transcription that orchestrates the cellular response to stress. Dysregulation of TFEB associated with range human diseases, and understanding regulatory mechanisms crucial for identifying potential drug targets. In this study, we used Caenorhabditis elegans screen E3 ubiquitin ligases regulating activity TFEB's homolog, HLH-30, upon pathogenic infection. We identified WWP-1 as regulator HLH-30-dependent immune controlling HLH-30 stability mediate host...
A growing number of patients presenting severe combined immunodeficiencies attributed to monoallelic RAC2 variants have been identified. The expression the RHO GTPase is restricted hematopoietic lineage. described cause associated with high frequency infection, leukopenia, and autoinflammatory features. Here, we show that specific activating mutations induce NLRP3 inflammasome activation leading secretion IL-1β IL-18 from macrophages. This depends on state variant mediated by downstream...
The term ‘thyroid tumors of uncertain malignant potential’ (TT-UMP) was coined by surgical pathologists to define well-differentiated (WDT) showing inconclusive morphological evidence malignancy or benignity. We have analyzed the expression microRNA (miRNA) in a training set 42 WDT different histological subtypes: seven follicular UMP (FT-UMP), six WDT-UMP, thyroid adenomas (FTA), 11 conventional papillary carcinomas (C-PTC), five variants PTC (FV-PTC), and (FTC), which led identification...
Wolbachia symbionts are maternally inherited intracellular bacteria that have been detected in numerous insects including bed bugs. The objective of this study, the first epidemiological study Europe, was to screen infection among Cimex lectularius collected field, using PCR targeting surface protein gene (wsp), and compare obtained strains with those reported from laboratory colonies C. as well other groups. For purpose, 284 bug specimens were caught studied eight different regions France...
High-risk human papillomaviruses (HPVs) have been identified as the main contributors to cervical cancer. Despite various diagnostic tools available, including predominant Papanicolaou test (Pap test), technical limitations affect efficiency of cancer screening. The aim this study was evaluate performance spliced HPV16 E6/E7 mRNA viral loads (VL) for grade 2 or higher intraepithelial neoplasia diagnosis. A new dedicated (quantitative reverse transcription polymerase chain reaction) qRT-PCR...
We previously isolated human papillomavirus 83 (HPV83m) from a cervical smear. Sequence analysis of E6 and E7 proteins highlighted five mutations located in the second putative zinc-finger region (E6m), an important domain for protein–protein or protein–DNA interactions. Here, we show that E6m HPV83m can trigger primary cell proliferation anchorage-independent growth properties, similarly to HPV16, high-risk HPV (HR-HPV). Interestingly, demonstrate that, contrast corrupts neither p53...
HPV16 DNA associated with histologic high-grade precancer lesions (cervical intraepithelial neoplasia grade 2 or 3 [CIN2 CIN3]) is sometimes found in women atypical squamous cells of undetermined significance (ASCUS) Pap smears, the mildest form cellular abnormality a cervical smear.This study evaluated, population patients ASCUS prevalence different lineages (or isolates) and physical status, total viral load, integrated load population, stratified by isolates (primarily either EUR-350T...