A5080179098- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Optimism, Hope, and Well-being
- Single-cell and spatial transcriptomics
- COVID-19 Clinical Research Studies
- Phagocytosis and Immune Regulation
- SARS-CoV-2 and COVID-19 Research
- Reproductive System and Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Inflammasome and immune disorders
- Macrophage Migration Inhibitory Factor
- Omental and Epiploic Conditions
- Inflammatory mediators and NSAID effects
- Inflammation biomarkers and pathways
- Atherosclerosis and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Adrenal Hormones and Disorders
- Diet, Metabolism, and Disease
- Clostridium difficile and Clostridium perfringens research
- Alcohol Consumption and Health Effects
- Pancreatic function and diabetes
Université Côte d'Azur
2019-2025
Centre National de la Recherche Scientifique
2022-2025
Laboratoire de PhysioMédecine Moléculaire
2022-2025
Observatoire de la Côte d’Azur
2020-2025
Centre Méditerranéen de Médecine Moléculaire
2019-2024
Washington University in St. Louis
2023-2024
Inserm
2019-2022
Creative Commons
2020
Zero to Three
2019
Along with respiratory tract disease per se , viral infections can also cause extrapulmonary complications a potentially critical impact on health. In the present study, we used an experimental model of influenza A virus (IAV) infection to investigate nature and outcome associated gut disorders.
Despite the ubiquitous function of macrophages across body, diversity, origin, and adrenal gland remain largely unknown. We define heterogeneity immune cells using single-cell RNA sequencing use genetic models to explore developmental mechanisms yielding macrophage diversity. populations monocyte-derived embryonically seeded identify a female-specific subset with low major histocompatibility complex (MHC) class II expression. In adulthood, monocyte recruitment dominates maintenance in female...
Abstract Monocytes are part of the mononuclear phagocytic system. play a central role during inflammatory conditions and better understanding their dynamics might open therapeutic opportunities. In present study, we focused on characterization impact monocytes brown adipose tissue (BAT) functions remodeling. Single-cell RNA sequencing analysis BAT immune cells uncovered large diversity in monocyte macrophage populations. Fate-mapping experiments demonstrated that pool requires constant...
Glucocorticoid synthesis by adrenal glands (AGs) is regulated the hypothalamic-pituitary-adrenal axis to facilitate stress responses when host exposed stimuli. Recent studies implicate macrophages as potential steroidogenic regulators, but molecular mechanisms which AG exert such influence remain unclear. In this study, we investigated role of in response cold challenge or atherosclerotic inflammation physiologic models acute chronic stress. Using single-cell RNA sequencing, observed dynamic...
Background and Aims: Alcohol-related liver disease (ALD) is one of the leading causes severe with limited pharmacological treatments for alcohol-related steatohepatitis (ASH). CD44, a glycoprotein mainly expressed in immune cells, has been implicated multiple inflammatory diseases but never studied ALD context. We therefore its contribution to ASH development mice expression patients Approach Results: Here, we report that CD44 associated injury inflammation deficiency ( Cd44 -/- ) partially...
Mouse resident peritoneal macrophages, called large cavity macrophages (LCM), arise from embryonic progenitors that proliferate as mature, CD73+Gata6+ tissue-specialized macrophages. After injury irradiation or inflammation, monocytes are thought to replenish LCMs through a CD73-LYVE1+ LCM intermediate. Here, we show indeed yield Gata6+CD73+ integrin-mediated interactions with mesothelial surfaces. repopulation of the peritoneum was reliant upon and quantitatively proportional recruited...
Synovial joints harbor a protective lining layer, consisting of fibroblasts and macrophages, which form an epithelial-like barrier. In inflamed joints, macrophages regulate both early inflammatory cell influx resolution. Despite these critical functions, it is currently unknown at what stage during development the synovial macrophage established, signals drive this process. Here, we use combination genetic models in vivo perturbations, single transcriptomics imaging to delineate process...
Abstract Macrophages play a central role during infection, inflammation and tissue homeostasis maintenance. have been identified in all organs their core transcriptomic signature functions differ from one to another. Interestingly, macrophages also the peritoneal cavity these cells extensively used as model for phagocytosis, efferocytosis polarization. Peritoneal are involved B‐cell IgA production, control of wound healing following thermal‐induced liver surface injury. These presumably...
Abstract Brown adipose tissue (BAT) contains many immune cells. The presence of macrophages, monocytes, dendritic cells, T B and mast cells was documented in BAT. However, comparison to white tissue, relatively little is known on the impact BAT function. By directly interacting with stromal or by secreting pro- anti-inflammatory mediators, modulate activation subsequently influence adaptative thermogenesis heat generation. In current manuscript, we will focus diversity functions
Abstract Stress exposure has been shown to modulate innate and adaptive immune responses. Indeed, stress favors myelopoiesis monocyte generation contributes cardiovascular disease development. As sex hormones regulate responses, we decided investigate whether leads a different response in female male mice. Our data demonstrated that psychosocial stressinduced neutrophilia male, but not Importantly, identified B‐cell numbers were reduced female, mice upon stress. Thus, our study revealed the...
Abstract Monocytes directly contribute to atherosclerosis development by their recruitment plaques in which they differentiate into macrophages. In the present study, we ask how modulating monocyte glucose metabolism could affect homeostasis and impact on atherosclerosis. Here investigate circulating metabolites control behavior blood, bone marrow peripheral tissues of mice. We find that serum concentrations correlate with numbers. diet-restricted mice, monocytes fail metabolically reprogram...
Abstract More than 80% of ovarian cancer (OC) cases have metastasized to the peritoneal cavity at diagnosis. The five-year survival rate for these patients is 25%. Within cavity, most common and early site metastasis omentum, a well-vascularized, specialized adipose tissue that arises off greater curvature stomach. Because OC homes it removed as standard care with metastases. In mouse models, omentum also an metastatic site, omentectomy reduces tumor expansion. mechanism by which promotes...
Macrophages are innate immune cells present in all tissues, which they participate responses and maintenance of tissue homeostasis. They develop either from embryonic precursors or circulating monocytes, their functions part dictated by origin. We previously observed robust monocyte recruitment contribution to the macrophage pool brown adipose tissue. In particular, monocytes were predicted give rise two phenotypically distinct subsets identifiable CD206 CD226 expression. study, we...
Abstract Myeloid cells are key contributors to tissue, immune and metabolic homeostasis their alteration fuels inflammation associated disorders such as atherosclerosis. Conversely, in a classical chicken-and-egg situation, systemic local metabolism, together with receptor-mediated activation, regulate intracellular metabolism reprogram myeloid cell functions. Those regulatory loops notable during the development of atherosclerotic lesions. Therefore, understanding intricate mechanisms...
Lymphatic collecting vessels and lymph nodes are inevitably embedded in adipose tissue. The physiological significance of this observation remains still not elucidated. However, obesity is characterized by impaired lymphatic function increased vessel permeability. Inversely, dysfunction induces mice, suggesting a significant interplay between the Therefore, understanding factors leading to might open new therapeutic windows prevent associated comorbidities. first step process requires...
Abstract In murine peritoneal and other serous cavities, Gata6 drives identity of the major resident cavity macrophage population, with a smaller subset macrophages dependent upon Irf4. Here we show that Gata6+ in human peritoneum are rare, regardless age. Instead, many aligned CD206 + LYVE1 mouse from differentiation stage just preceding expression Gata6. The comparatively low abundance converting healthy C57BL/6J mice was sustained after high-fat diet feeding or capture wild, suggesting...