A5038357548- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS drug development and treatment
- Organ Transplantation Techniques and Outcomes
- Drug Transport and Resistance Mechanisms
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Biosimilars and Bioanalytical Methods
- Antifungal resistance and susceptibility
- Inflammatory Bowel Disease
- Pharmacogenetics and Drug Metabolism
- Hepatitis C virus research
- Transplantation: Methods and Outcomes
- Immunodeficiency and Autoimmune Disorders
- Herpesvirus Infections and Treatments
- Analytical Methods in Pharmaceuticals
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Microscopic Colitis
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Platelet Disorders and Treatments
- Analytical Chemistry and Chromatography
- Pharmaceutical studies and practices
Centre Hospitalier Universitaire de Rennes
2016-2025
CIC Rennes
2016-2025
Institut de Recherche en Santé, Environnement et Travail
2020-2024
École des Hautes Études en Santé Publique
2020-2024
Université de Rennes
2016-2024
Hôpital Pontchaillou
2016-2024
Inserm
2015-2023
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2023
Clinical Investigation Center Plurithematic Tours
2019-2020
Ibero American University
2018
Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim our study was evaluate impact TAC IPV on graft patient outcomes after LT.We retrospectively analyzed 812 LT recipients treated with TAC. concentrations estimated calculating coefficient variation (CV) whole blood trough concentrations....
This study aimed at exploring the link among individual concentrations, pharmacokinetic parameters, and probability of relapse after de-escalation in a real-world prospective cohort patients with inflammatory bowel disease (IBD) who underwent infliximab treatment de-escalation. Ninety-one were included. A time-varying compartment model was used to estimate parameters trough concentrations. Cox implemented explore influencing Volume, clearance, before linked risk univariate step. Independent...
ABSTRACT Posaconazole is extensively used for prophylaxis invasive fungal infections. The gastro-resistant tablet formulation has allowed the bioavailability issues encountered with oral suspension to be overcome. However, overexposure now frequent. This study aimed (i) describe pharmacokinetics of posaconazole tablets in a real-life cohort patients hematological malignancies and (ii) perform Monte Carlo simulations assess possibility that daily dose can reduced while keeping sufficient...
Background: Therapeutic drug monitoring (TDM) of the 2 calcineurin inhibitors (CNIs), tacrolimus (TAC) and cyclosporin A, has resulted in improvements management patients who have undergone solid organ transplantation. As a result TDM, acute rejection (AR) rates treatment-related toxicities been reduced. Irrespective, AR toxicity still occur transplantation, showing blood CNI concentrations within therapeutic range. Moreover, rate is no longer decreasing. Hence, smarter TDM approaches are...
Tacrolimus (TAC) is the cornerstone of immunosuppressive therapy in liver transplantation. This study aimed at elucidating interplay between pharmacogenetic determinants TAC whole blood and intracellular exposures as well pharmacokinetic-pharmacodynamic relationship both compartments. Complete pharmacokinetic profiles (Predose, 20 min, 40 1h, 2h, 3h, 4h, 6h, 8h, 12h post drug intake) twice daily peripheral mononuclear cells (PBMC) were collected 32 transplanted patients first ten days A...
Determining dihydropyrimidine dehydrogenase (DPD) activity by measuring patient's uracil (U) plasma concentration is mandatory before fluoropyrimidine (FP) administration in France. In this study, we aimed to refine the pre-analytical recommendations for determining U and dihydrouracil (UH2 ) concentrations, as they are essential reliable DPD-deficiency testing.U UH2 concentrations were collected from 14 hospital laboratories. Stability whole blood after centrifugation, type of anticoagulant...
Abstract Background No clinical trial has previously assessed the best therapeutic strategy between switching to another anti-TNF or swapping class of biologic after failure a first in ulcerative colitis (UC). The aim EFFICACI was compare efficacy vedolizumab with infliximab patients who had failed sub-cutaneous (golimumab and/or adalimumab). Methods French double-blind multicenter randomized controlled (1:1) comparing intravenous 300 mg at weeks 0-2-6 5 mg/kg 0-2-6. Eligible...
Introduction Tyrosine kinase inhibitors (TKIs) have revolutionized survival rates of chronic myeloid leukemia (CML) and Philadelphia chromosome positive (Ph+) acute lymphoblastic (ALL) replaced hematopoietic stem cell transplantation (hSCT) as the key treatment option for these patients. More recently, so-called chromosome-like (Ph-like) ALL has similarly benefitted from TKIs. However, many patients shift first generation TKI, imatinib, due to treatment-related toxicities or lack efficacy. A...
Recently, the pig liver model perfused ex vivo using a normothermic machine perfusion (NMP) has been proposed as suitable to study xenobiotic metabolism and biliary excretion. The aim of our is describe NPS such cathinones (with focus on 4-Cl-PVP eutylone) in blood bile, model. Livers (n = 4) from male large white pigs, 3-4 months age weighing approximately 75-80 kg, were harvested reperfused onto an NMP (LiverAssist®, XVIVO) autologous whole at 38 °C. eutylone administered bolus circulating...
Risperidone, aripiprazole, and pipamperone are antipsychotic drugs frequently prescribed for the treatment of comorbid behavioral problems in children with autism spectrum disorders. Therapeutic drug monitoring (TDM) could be useful to decrease side effects improve patient outcome. Dried blood spot (DBS) sample collection seems an attractive technique develop TDM these a pediatric population. The aim this work was validate DBS assay suitable home sampling.Risperidone, 9-OH risperidone,...
Background: This study compared the performance of plasma infliximab and adalimumab quantification using a commercially available kit (mAbXmise kit) mass spectrometry readout to that two ELISA methods in patients treated for inflammatory bowel disease. Methods & results: The mAbXmise method based on liquid chromatography tandem (LC-MS/MS) was linear from 2 100 μg/ml. It validated according international guidelines. Regarding cross-validation (n = 70), mean bias with LC-MS/MS assay...
Antidrug antibodies (ADAs) dramatically increase infliximab clearance and are responsible for underexposure to the drug, leading treatment failure. This pilot study aimed at developing a population pharmacokinetic model detect describe an early in due ADA.Twenty children with Crohn's disease (CD) were followed 1 year or until Infliximab trough concentration, ADA, C-reactive protein (CRP), Paediatric Disease Activity Index (PCDAI) recorded each visit. A time-varying was built clearance,...
Abstract Measuring tacrolimus (TAC) concentration in peripheral blood mononuclear cells (PBMCs) could better reflect the drug effect on its target (calcineurin (CaN) lymphocytes) than whole concentrations. Mechanisms influencing TAC diffusion into PBMC are not well characterized. This work aimed at describing, ex vivo , kinetics and investigating contribution of membrane transporters to regulate intracellular as impact CaN activity. PBMCs were incubated with for 5 min 4 h under several...
Voriconazole (VRC), a widely used triazole antifungal, exhibits significant inter- and intra-individual pharmacokinetic variability. The main metabolite voriconazole N-oxide (NOX) can provide information on the patient's drug metabolism capacity.Our objectives were to implement routine measurement of NOX concentrations describe metabolic ratio (MR), contribution MR VRC therapeutic monitoring (TDM) by proposing suggested dosage-adjustment algorithm.Sixty-one patients treated with...