Emmanuel Rineau
A5045260071- Cardiac, Anesthesia and Surgical Outcomes
- Erythropoietin and Anemia Treatment
- Blood transfusion and management
- Anesthesia and Pain Management
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Respiratory Support and Mechanisms
- Hip and Femur Fractures
- Enhanced Recovery After Surgery
- Nausea and vomiting management
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Trauma and Emergency Care Studies
- Simulation-Based Education in Healthcare
- Blood donation and transfusion practices
- Pain Management and Opioid Use
- Heart Failure Treatment and Management
- Health, Medicine and Society
- Anesthesia and Neurotoxicity Research
- Acute Kidney Injury Research
- Artificial Intelligence in Healthcare and Education
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
Université d'Angers
2015-2025
Centre Hospitalier Universitaire d'Angers
2014-2025
Centre National de la Recherche Scientifique
2013-2024
Inserm
2013-2024
Mitochondrial and Cardiovascular Physiopathology
2024
Nantes Université
2022
Centre Hospitalier Universitaire de Rennes
2018
CIC Rennes
2018
Université Nantes Angers Le Mans
2013-2016
Imation (United States)
2014-2016
The incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries health care systems is unclear. We conducted an international prospective, observational, multi-center study in 30 patients undergoing major surgery (> 2-h duration intensive unit (ICU) or high dependency admission). primary endpoint was the occurrence PO-AKI within 72 h defined by Kidney Disease: Improving Global Outcomes (KDIGO) criteria....
Background. Opioid-free anesthesia (OFA) is increasingly being adopted to reduce opioid consumption, but its impact on early postoperative recovery following major surgery has not been evaluated in comparative trials. We hypothesized that an OFA protocol would enhance the quality of (QoR) for patients undergoing scheduled under general anesthesia.Methods. The SOFA study was a monocentric, randomized, controlled, assessor- and patient-blinded clinical trial conducted from July 10, 2021,...
Abstract Background After cardiac surgery, post-operative delirium (PoD) is acknowledged to have a significant negative impact on patient outcome. To date, there no valuable and specific treatment for PoD. Critically ill patients often suffer from poor sleep condition. There an association between quality after surgery. This study aimed establish whether promoting using overnight infusion of dexmedetomidine reduces the incidence Methods Randomized, pragmatic, multicentre, double-blind,...
Acute kidney disease (AKD) is a significant health care burden worldwide. However, little known about this complication after major surgery.
Patient blood management (PBM) must be promoted in orthopedic surgery and relies on different strategies implemented during the entire perioperative period. Our aim was to assess whether introduction of a pre-, intra-, postoperative PBM protocol combining erythropoietin (EPO), ferric carboxymaltose (FCM), tranexamic acid effective reducing transfusion anemia.In two-phase prospective observational study, all patients admitted for total hip or knee arthroplasty were included day before...
The QoR-15 scale is a validated tool to assess the quality of postoperative recovery (QoR). Our objective was association between early values and occurrence one-month complications.We used data from prospective single-centre cohort study conducted in Angers University Hospital July 2019 February 2020 that French version (FQoR-15).Preoperative room, ward, home.363 French-speaking adult patients, undergoing elective surgery, were enrolled (217 (59,8%) men, median age 60 (range 44 71) years...
Abstract Background Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), difficult to diagnose the context of inflammation. Hepcidin new marker ID. We aimed assess whether hepcidin levels would accurately guide treatment ID critically ill anemic after prolonged ICU stay and affect post-ICU outcomes. Methods In controlled, single-blinded, multicenter study, (WHO definition) with an ≥ 5 days were randomized when discharge was expected either...
Preoperative COVID-19 has been associated with excess postoperative morbi-mortality. Consequently, guidelines were developed that recommended the postponement of surgery for at least 7 weeks after infection. We hypothesised vaccination against SARS-CoV-2 and large predominance Omicron variant attenuated effect a preoperative on occurrence respiratory morbidity.We conducted prospective cohort study in 41 French centres between 15 March 30 May 2022 (ClinicalTrials NCT05336110), aimed comparing...
Iron deficiency (ID), with or without anemia, is responsible for physical fatigue. This effect may be linked to an alteration of mitochondrial metabolism. Our aim was assess the impact ID on skeletal striated muscle Iron-deficient non-anemic mice, obtained using a bloodletting followed by low-iron diet three weeks, were compared control mice. Endurance assessed one-hour submaximal exercise Rotarod device and activities complexes I IV measured spectrophotometry two types muscles, soleus...
Cardiopulmonary bypass (CPB) during cardiac surgery mechanically circulates and oxygenates the blood, bypassing heart lungs. Despite limited evidence, maintaining mechanical ventilation (MV) CPB is recommended, as ventilator strategies may reduce occurrence of postoperative infections. We aimed to determine whether MV for would decrease infections compared with stopping CPB. conducted a multicenter, single-blind, randomized trial among adult patients undergoing scheduled in six hospitals...
Abstract Background Recently, Objective Structured Clinical Examinations (OSCE) became an official evaluation modality for 6-year medical students in France. Before, standard examination modalities were: written progressive clinical cases (PCC), critical reading of scientific articles (CRA), and internship (IE). The aim this study was to assess the performances their final faculty tests by comparing OSCE-exams with modalities. Methods This a prospective observational study. We included all...
Preventive anesthetic impact on the high rates of postoperative neurocognitive disorders in elderly patients is debated. The Prevention postOperative Cognitive dysfunction by Ketamine (POCK) study aimed to assess effect ketamine this condition.
Erythropoietin (EPO) is proposed preoperatively to reduce blood transfusion in anemic patients (hemoglobin < 13 g/dL) scheduled for a major orthopedic surgery. New intravenous iron formulations allow infusion of higher doses, increasing EPO response. In that context, we evaluated before-after study (n = 62 and 65 each period) new administration protocol (2 injections 4 3 weeks before surgery, third if hemoglobin <13 g/dL instead <15 2 surgery). After this implementation, the mean (standard...
To compare the oxidative stress induced by IV iron infusion in critically ill patients and healthy volunteers.Multicenter, interventional study.Two ICUs one clinical research center.Anemic treated with volunteers.IV of 100 mg sucrose.Thirty-eight anemic (hemoglobin, median [interquartile range] = 8.4 g/dL [7.7-9.2]) (men, 25 [66%]; aged 68 yr [48-77]; Simplified Acute Physiology Score II, 48.5 [39-59]) 39 volunteers 18 [46%]; 42.1 [29-50]) were included. Blood samples drawn before (H0) 2, 6,...