A5054201768- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Anesthesia and Sedative Agents
- Blood transfusion and management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Acute Kidney Injury Research
- Trauma and Emergency Care Studies
- Nausea and vomiting management
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Muscle and Compartmental Disorders
- Atrial Fibrillation Management and Outcomes
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Pediatric Pain Management Techniques
- S100 Proteins and Annexins
- Abdominal Surgery and Complications
- Nosocomial Infections in ICU
- Clusterin in disease pathology
University Hospital Ostrava
2016-2025
University of Ostrava
2014-2025
Czech Academy of Sciences, Institute of Physiology
2022-2025
University Children's Hospital Tübingen
2023
Resuscitation Council
2023
Comenius University Bratislava
2020
Vysoká Škola Zdravotníctva a Sociálnej Práce sv. Alžbety
2020
Charles University
2014
The incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries health care systems is unclear. We conducted an international prospective, observational, multi-center study in 30 patients undergoing major surgery (> 2-h duration intensive unit (ICU) or high dependency admission). primary endpoint was the occurrence PO-AKI within 72 h defined by Kidney Disease: Improving Global Outcomes (KDIGO) criteria....
Background and Aims: Delirium is an acute brain dysfunction a frequent complication in critically ill patients. When present it significantly worsens the prognosis of The aim this study was to evaluate incidence delirium risk factors for mixed group trauma, medical surgical ICU Methods: A prospective observational conducted one six-bed Intensive Care Units University Hospital Ostrava Czech Republic during 12-month period. We evaluated its predisposing precipitating factors. All patients were...
Abstract Background Postoperative nausea and vomiting (PONV) is a significant problem following paediatric surgery, volatile anaesthetics are an important cause of this phenomenon. BIS-guided anaesthesia, by reducing the consumption anaesthetics, leads to decrease in PONV adult patients. Study objective Evaluate role anaesthesia incidence PONV. Design Prospective, randomized, double-blind study. Setting A single center study university hospital Czech republic, from June 2021 November 2022....
Emergence delirium (ED) is a postoperative complication in pediatric anesthesia characterized by perception and psychomotor disorder, with negative impact on recovery. As the use of inhalation associated higher incidence ED, we investigated whether titrating depth general BIS monitor can reduce ED. Randomized, prospective, double-blind. Patients undergoing endoscopic adenoidectomy under according to uniform protocol. A total 163 patients both sexes aged 3-8 years were enrolled over 18...
Abstract Background Anticoagulation during extracorporeal membrane oxygenation (ECMO) might still lead to severe bleeding complications. Heparin is the most frequently used anticoagulant, but novel drugs could be promising. Argatroban a new alternative heparin. To date, no robust studies have confirmed clear superiority of argatroban (AG) over heparin, although it has some advantages and may safer. Study Design Methods An observational study was conducted in all adult veno‐venous ECMO...
Massive bleeding causes approximately 50% of deaths in patients with major trauma. Most die within 6 h injury, which is preventable at least 10% cases. For these patients, early activation the massive transfusion protocol (MTP) a critical survival factor. With severe trauma, high-mobility group box 1 (HMGB-1, i.e., amphoterin) released into blood, and its levels correlate development systemic inflammatory response, traumatic coagulopathy, fibrinolysis. Previous work has shown that higher...
Unfractionated heparin has long been considered the standard anticoagulation in ECMO, despite some pitfalls such as resistance, induced thrombocytopenia (HIT), etc Recently, centres started to increasingly use argatroban for this purpose, typically using activated partial thromboplastin time (aPTT) its monitoring. Direct monitoring of efficacy Anti-IIa is not yet an established method, although it might be more appropriate targets same pathway.An observational study was performed adult...
Abstract Cerebral protection against secondary hypoxic-ischemic brain injury is a key priority area in post-resuscitation intensive care management survivors of cardiac arrest. Nevertheless, the current understanding incidence, diagnosis and its’ impact on neurological outcome remains undetermined. The aim this study was to evaluate jugular bulb oximetry as potential monitoring modality detect incidences desaturation episodes during post-cardiac arrest their subsequent outcome. We conducted...
Purpose: Tissue injury causing immune response is an integral part of surgical procedure. Evaluation the degree trauma could help to improve postoperative management and determine clinical outcomes. Materials Methods: We analyzed serum levels alarmins, including S100A5, S100A6, S100A8, S100A9, S100A11, S100A12; high-mobility group box 1; heat-shock protein 70, after elective major abdominal surgery (n = 82). Blood samples were collected for three consecutive days surgery. The goals evaluate...
Intensive care of severe trauma patients focuses on the treatment haemorrhagic shock. Tissues should be perfused sufficiently with blood and sufficient oxygen content to ensure adequate tissue delivery. Tissue metabolism can monitored by microdialysis, lactate/pyruvate ratio (LPR) may used as a ischemia marker. The aim this study was determine cardiac output haemoglobin levels that avoid ischemia. Adult serious traumatic shock were enrolled in prospective observational study. primary...
AbstractAbstractAbdominal compartment syndrome (ACS) is defined as a sustained increase of intra-abdominal pressure (IAP) above 20 mmHg followed by the development organ dysfunction. Treatment ACS still question to be discussed and surgical decompression usually preferred. According recent data, massive crystalloid resuscitation shock plays key role in secondary trauma patients. As mentioned previously, high volume infused crystalloids positive fluid balance were associated with patients...
Background:Acute kidney injury (AKI) is a common cause of organ failure in patients after major trauma and associated with increased morbidity mortality.Early identification at risk enables the implementation bundle supportive care, which reduces incidence AKI.The primary objective our study was to investigate whether levels biomarkers on admission predicted onset early AKI serious injuries. Material/Methods:This prospective observational included 98 adult both sexes (injury severity score...
The well-described disparity between the need for and supply of organs suitable transplant is growing. Because this disparity, mortality patients listed increasing. Donors who die intoxication (including victims methanol poisoning) represent less than 1% donors might be used to increase organs. They are often not accepted as by specialists, because concerns about patients' outcomes with these grafts. Three cases fatal that resulted in transplants 6 kidneys evaluated.
Maintaining the patient awake and not intubated during venovenous extracorporeal membrane oxygenation (VV ECMO) reduces risk of ventilation-induced lung injury in patients with ARDS. Currently, there is a lack data on outcomes complications associated ECMO approach.
Dexamethasone 6 mg in patients with severe COVID-19 has been shown to decrease mortality and morbidity. The effects of higher doses corticosteroid, that would further increase anti-inflammatory effects, are uncertain. objective our study was assess the effect 20 dexamethasone vs. intravenously moderate-to-severe acute respiratory distress syndrome (ARDS) COVID-19. In a multicenter, open-label, randomized trial conducted nine hospitals Czech Republic, we adult ARDS requiring high-flow oxygen,...