A5032229582- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Trauma Management and Diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Tracheal and airway disorders
- Electrical and Bioimpedance Tomography
- Hemodynamic Monitoring and Therapy
- Ultrasound in Clinical Applications
- Liver Disease and Transplantation
- Obstructive Sleep Apnea Research
- Cardiac, Anesthesia and Surgical Outcomes
- Restraint-Related Deaths
- Antifungal resistance and susceptibility
- Amoebic Infections and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neuroscience of respiration and sleep
- Thermal Regulation in Medicine
- Parasitic Diseases Research and Treatment
- Ear and Head Tumors
- Environmental Science and Water Management
- Muscle and Compartmental Disorders
- Hepatitis B Virus Studies
Military University Hospital Prague
2015-2025
Charles University
2012-2024
Czech Technical University in Prague
2020
Thomayer University Hospital
2011-2012
Objectives . Five different second-generation supraglottic airway devices, ProSeal LMA, Supreme i-gel, SLIPA, and Laryngeal Tube Suction-D, were studied. Operators inexperienced users with a military background, combat lifesavers, nurses, physicians. Methods This was prospective, randomized, single-blinded study. Devices inserted in the operating room low light conditions after induction of general anesthesia. Primary outcome successful insertion on first attempt while secondary aims time,...
BACKGROUND The short shelf‐life of fresh platelets limits their efficient inventory management and availability during a massive transfusion protocol. Risk insufficient can be mitigated by building an cryopreserved (CPs). METHODS A comparative study apheresis (FAPs) CPs was performed. Type‐O were processed with DMSO frozen at −80°C reconstituted in thawed AB plasma. All patients enrolled the had following parameters evaluated on admission: vital signs (body temperature, heart rate, mean...
Objectives: Maintaining diaphragm work using electrical stimulation during mechanical ventilation has been proposed to attenuate ventilator-induced dysfunction. This study assessed the safety and feasibility of temporary percutaneous phrenic nerve on user-specified inspiratory breaths while ventilation. Design: Two-center, nonblinded, nonrandomized study. Setting: Hospital ICU. Patients: Twelve patients mechanically ventilated from 48 hours an expected 7 days. Interventions: Leads were...
Abstract Background Diaphragm atrophy and dysfunction is a major problem among critically ill patients on mechanical ventilation. Ventilator-induced diaphragmatic thought to play role, resulting in failure of weaning. Stimulation the phrenic nerves diaphragm contraction could potentially prevent or treat this atrophy. The subject study determine effectiveness stimulation preventing by measuring changes its thickness. Methods A total 12 intervention group 10 control were enrolled. thickness...
Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The purpose of the study was compare effects equivolume, equiosmolar mannitol hypertonic saline (HTS) on relaxation postoperative complications patients undergoing elective intracranial tumor surgery.In this prospective, randomized study, with American Society Anesthesiologists physical status I III scheduled undergo a craniotomy for tumors were enrolled. Patients received 3.75...
Background The risk of cardiovascular disease is closely connected to adipose tissue inflammation. links between predictors and pro anti-inflammatory macrophages in human were analysed gain an insight into the pathophysiology disease. Design Subcutaneous visceral tissues obtained from 79 subjects, 52 living kidney donors (during nephrectomy) 27 patients with peripheral artery arterial tree reconstruction). Methods Macrophage subsets isolated by flow cytometry using CD14, CD16, CD36 CD163...
Abstract Introduction The aim of this study was to compare the early postoperative kinetics procalcitonin (PCT) and C-reactive protein (CRP) serum levels in patients undergoing orthotopic liver transplantation (OLTx) with different immunosuppressive regimens. Methods PCT CRP concentrations were measured a group 28 OLTx recipients before induction anesthesia, at 4 8 hours following graft reperfusion, daily until day 4. same parameters determined 12 resection without conjunctive therapy....
Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was compare the short-term effects equivolemic, equiosmolar mannitol hypertonic saline (HTS) on cerebral cortical microcirculation a rabbit craniotomy model.Rabbits (weight, 2.0-3.0 kg) were anesthetized, ventilated mechanically, subjected craniotomy. animals allocated randomly receive 3.75 ml/kg intravenous infusion either 3.2% HTS (group HTS, n =...
Introduction Supraglottic airway devices represent a less invasive method of management than tracheal intubation during general anaesthesia. Their continued development is focused mainly on improvements in the insertion success rate and minimalisation perioperative postoperative complications. The i-gel Plus novel, anatomically preshaped supraglottic device which achieves perilaryngeal seal due to non-inflatable cuff made soft thermoplastic elastomer. purpose this cohort study assess use...
Despite the many tools available to modern medicine, predicting neurological and functional status of patients after severe brain injury remains difficult.
Dexamethasone 6 mg in patients with severe COVID-19 has been shown to decrease mortality and morbidity. The effects of higher doses corticosteroid, that would further increase anti-inflammatory effects, are uncertain. objective our study was assess the effect 20 dexamethasone vs. intravenously moderate-to-severe acute respiratory distress syndrome (ARDS) COVID-19. In a multicenter, open-label, randomized trial conducted nine hospitals Czech Republic, we adult ARDS requiring high-flow oxygen,...
Cricothyrotomy is a rescue procedure in "cannot intubate, cannot oxygenate" scenarios where other methods of nonsurgical airway management have failed. We compared 2 cuffed cricothyrotomy sets, bougie-assisted (BACT) and novel percutaneous TracheoQuick Plus, on live porcine model simulated periarrest situation.Thirty-four anesthetized minipigs were randomly allocated into two groups: BACT technique (n = 17) Plus 17). The primary outcome was duration while secondary outcomes total success...
During laparoscopic surgery, a capnoperitoneum is created to optimize the operating space for surgeons. One effect of this abdominal pressure which alters physiological thoraco-abdominal configuration and pushes diaphragm lungs cranially. Since lung image acquired by electrical impedance tomography (EIT) depends on conditions within thorax abdomen, it crucial know position determine shift EIT image.The presence in region measurement was determined ultrasound 20 patients undergoing surgery....
The use of helium-oxygen mixture (heliox) for ventilation has an advantage in patients with obstruction the airways. physical properties helium enable easier gas flow through airways; this enables breathing patient when compared to standard air. A high cost heliox falls within factors that limit clinical practice. At present, is administered by open circuit. aim study propose a way administration reduces consumption but does not affect positive effects upon airway resistance.To minimize...
Primary hyperparathyroidism (HPPT) is a generalized disorder of calcium-phosphate metabolism resulting from long-term secretion parathyroid hormone (PTH). The most common cause PTH overproduction an adenoma one or more glands. Cerebral venous sinus thrombosis accounts for about 1–2% cerebral events and its consequence can be focal ischemia with intracerebral hemorrhage. In this article, we describe unique case report patient who was urgently admitted the progression sudden speech progressive...
The survival rate of patients with out-of-hospital cardiac arrest has improved in recent years; however, it remains low. One approach to improving outcomes these cases is implement point-of-care ultrasound as an integral part advanced life support management. Due its growing popularity among emergency physicians, several protocols for this examination have been developed; there are little data on use the prehospital setting. We present a case report role both diagnostic and therapeutic