A5041963322- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Veterinary Pharmacology and Anesthesia
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare Operations and Scheduling Optimization
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects and Assays
- Education, Psychology, and Social Research
- Operations Management Techniques
- Glioma Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Meningioma and schwannoma management
- Intraoperative Neuromonitoring and Anesthetic Effects
- Nitric Oxide and Endothelin Effects
- Climate Change and Health Impacts
- Treatment of Major Depression
- Torture, Ethics, and Law
- Thermal Regulation in Medicine
- Neuroendocrine regulation and behavior
- Foreign Body Medical Cases
- Clinical Nutrition and Gastroenterology
- Nausea and vomiting management
- Hospital Admissions and Outcomes
University Hospital Hradec Králové
2007-2019
Charles University
2005-2019
Intensive Care Foundation
2014
Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The purpose of the study was compare effects equivolume, equiosmolar mannitol hypertonic saline (HTS) on relaxation postoperative complications patients undergoing elective intracranial tumor surgery.In this prospective, randomized study, with American Society Anesthesiologists physical status I III scheduled undergo a craniotomy for tumors were enrolled. Patients received 3.75...
The Surgical Plethysmographic Index (SPI) and the Analgesia Nociception (ANI) have been suggested for non-invasive intraoperative monitoring of nociception/anti-nociception balance. We aimed to compare patterns use opioids, postoperative cortisol levels pain scores after analgesia guided either by ANI, SPI or anesthesiologist's judgment.Seventy-two adult ASA I-III patients scheduled elective neurosurgical spinal procedures were randomized into ANI group, group control group. Anesthesia...
Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was compare the short-term effects equivolemic, equiosmolar mannitol hypertonic saline (HTS) on cerebral cortical microcirculation a rabbit craniotomy model.Rabbits (weight, 2.0-3.0 kg) were anesthetized, ventilated mechanically, subjected craniotomy. animals allocated randomly receive 3.75 ml/kg intravenous infusion either 3.2% HTS (group HTS, n =...
The aim of the study was to compare effect naphthylmedetomidine medetomidine on behavior orangutans and chimpanzees.The immobilization performed as part a medical examination in five chimpanzees three orangutans. Following pre-medication with midazolam (0.70-1.20 mg/kg p.o.), (50-70 microg/kg), or (20-30 microg/kg) given ketamine (3 mg/kg) hyaluronidase (150 M.U.) into musculus deltoideus.We observed distinct anti-aggressive naphthylmedetomidine. shallower influence cardiac frequency less...
Hemorrhagic shock (HS) represents an acute event with high mortality. The optimal combination of anesthetics that would prevent hemodynamic collapse and allow damage control surgery has not yet been determined. We tested the hypothesis a dissociative anesthetic ketamine alpha2- agonist medetomidine (MK group, n=10) provide superior compared to propofol-remifentanil (PR during HS in minipigs. A modified Wiggers‘ model target mean arterial pressure (MAP) 40 mm Hg 2 h duration was used. All...
Background: Hyperosmolar solutions have been used in neurosurgery to modify brain bulk. The aim of this animal study was compare the short-term effects equivolemic, equiosmolar hypertonic saline (HTS) and sodium lactate (HTL) on cerebral cortical microcirculation tissue oxygenation a rabbit craniotomy model. Methods: Rabbits (weight, 1.5 2.0 kg) were anesthetized, ventilated mechanically, subjected craniotomy. animals allocated randomly receive 3.75 mL/kg intravenous infusion either 3.2% HTS...
The aim of this study was to compare cardiorespiratory and behavioral profile a new alpha 2-adrenoceptor ligand naphthylmedetomidine with medetomidine in rhesus monkeys.Naphthylmedetomidine or (50 microg/kg) together ketamine (3 mg/kg) hyaluronidase (150 IU/kg) i.m administered 35 monkeys. Behavioral changes were then observed blood pressure, heart rate oxygen saturation hemoglobin.The onset sedation, ataxia, reduction aggression similar both treatment groups. Immobilization only treated...
BACKGROUND: Perioperative hypothermia is a common complication of surgery. The hypothesis, that new self-warming blanket (Barrier® EasyWarm®, Molnlycke Health Care) better at reducing the incidence perioperative in spinal surgery compared to passive insulation techniques, was tested. METHODS: In this prospective randomized study, 100 patients with American Society Anesthesiologists physical status I–III who were scheduled undergo surgical procedures an expected duration <2 hours enrolled....
Dept. of Anesthesiology and Intensive Care Medicine, Charles University Prague, Faculty Hospital, Hradec Kralove, Czech Republic
Department of Anesthesiology and Intensive Care Medicine, Charles University in Prague, Faculty Medicine Hospital Hradec Kralove, Czech Republic
Fazit Möglicherweise ist zur Hirndrucksenkung in der elektiven Situation die Gabe einer 3,2 %igen Kochsalzlösung des gleichen Volumens von 20 %igem Mannitol überlegen, wobei Osmolarität beiden Lösungen gleiche ist, so Autoren. Das könnte teilweise damit zusammenhängen, dass Blut-Hirn-Schranke geringem Ausmaß passieren kann, im Gegensatz Kochsalzlösung, und Verlagerung interstitiellen Flüssigkeit ins extrakranielle Gefäßsystem etwas weniger effektiv ist. Allerdings tragen zu einem Hirnödem...
Department of Anaesthesiology and Intensive Care, Charles University in Prague, Faculty Medicine Hradec Kralove, Hospital Czech Republic
Cíl studie: Obtíže v průběhu přímé laryngoskopie nebo suboptimální vizualizace struktur hrtanu mohou být spojeny s nesprávným umístěním tracheální rourky lokálním poraněním dýchacích cest. Cílem této studie bylo porovnat iniciální hloubku zavedení rourky, četnost nechtěné endobronchiální intubace a výskyt pooperačního diskomfortu po intubaci pomocí videolaryngoskopu (GlideScope Titanium) Macintoshova laryngoskopu. Typ Prospektivní randomizovaná otevřená studie. pracoviště: Operační sály...