A5079827685- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Immune Response and Inflammation
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Arrest and Resuscitation
- Diabetes and associated disorders
- Long-Term Effects of COVID-19
- Bone and Dental Protein Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac and Coronary Surgery Techniques
- Cytokine Signaling Pathways and Interactions
- Thermal Regulation in Medicine
- Fungal Infections and Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Periodontal Regeneration and Treatments
- Mechanical Circulatory Support Devices
- Antifungal resistance and susceptibility
- Forensic and Genetic Research
- COVID-19 Impact on Reproduction
Centre Hospitalier Universitaire de Rennes
2016-2025
Inserm
2001-2025
Université de Rennes
2014-2025
Établissement Français du Sang
2016-2024
Université Rennes 2
2016-2024
Structure Fédérative de Recherche en Biologie et Santé de Rennes
2017-2022
Immunité et Cancer
2022
Microenvironment and B-cells: Immunopathology, Cell, Differentiation and Cancer
2022
Hôpital Pontchaillou
2021
Sepsis induces a sustained immune dysfunction responsible for poor outcome and nosocomial infections. Myeloid-derived suppressor cells (MDSCs) described in cancer inflammatory processes may be involved sepsis-induced suppression, but their clinical impact remains poorly defined.To clarify phenotype, suppressive activity, origin, of MDSCs patients with sepsis.Peripheral blood transcriptomic analysis was performed on 29 sepsis 15 healthy donors. A second cohort 94 consecutive sepsis, 11...
Exaggerated release of neutrophil extracellular traps (NETs) along with decreased NET clearance and inability to remove apoptotic cells (efferocytosis) may contribute sustained inflammation in acute respiratory distress syndrome (ARDS). Recent studies experimental models ARDS have revealed the crosstalk between AMP-activated protein kinase (AMPK) high-mobility group box 1 (HMGB1), which effectiveness efferocytosis, thereby reducing severity.We investigated by macrophages from control...
Although resistin was recently found to modulate insulin resistance in preclinical models of type II diabetes and obesity, recent studies also suggested that has proinflammatory properties. We examined whether the human-specific variant affects neutrophil activation severity LPS-induced acute lung injury. Because human mouse have distinct patterns tissue distribution, experiments were performed using humanized mice exclusively express (hRTN(+/-)(/-)) but are deficient resistin. Enhanced...
// Murielle Grégoire 1,2,3 , Fabien Guilloton Céline Pangault 1,2,3,4 Frédéric Mourcin Phaktra Sok 1,2,3,5 Maelle Latour 3,4 Patricia Amé-Thomas Erwan Flecher 6 Thierry Fest and Karin Tarte 1 INSERM, UMR U917, Equipe Labellisée Ligue Contre le Cancer, Rennes, France 2 Université Rennes 1, UMR917, 3 EFS Bretagne, 4 CHU de Pôle Biologie, 5 Service Médecine L'enfant et L'adolescent, Chirurgie Thoracique Cardiovasculaire, Correspondence to: Tarte, email: Keywords : B-cell lymphoma, tumor...
Abstract Sepsis is accompanied by the initial activation of proinflammatory pathways and long-lasting immunosuppression that appears to contribute late-occurring mortality. Although high-mobility group box 1 (HMGB1) involved in many aspects inflammation, its role sepsis-induced immune suppression remains unclear. In this study, we examined HMGB1’s contribution neutrophil NADPH oxidase activity dysfunction associated neutrophil-dependent bacterial clearance mice subjected sepsis patients who...
Severe sepsis induces a sustained immune dysfunction associated with poor clinical behavior. In particular, lymphopenia along increased lymphocyte apoptosis and decreased proliferation, enhanced circulating regulatory T cells (Treg), the emergence of myeloid-derived suppressor (MDSCs) have all been persistent organ dysfunction, secondary infections, late mortality. The mechanisms involved in MDSC-mediated cell during share some features those described malignancies such as arginine...
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides heart mechanical support in critically ill patients with cardiogenic shock. Despite important progresses the management of under VA-ECMO, acquired infections remain extremely frequent and increase mortality rate. Since immune dysfunctions have been described both after surgery cardiopulmonary bypass, VA-ECMO initiation may be responsible for alterations that expose to nosocomial (NI). Therefore, this prospective study, we...
Cardiac surgery with cardiopulmonary bypass (CPB) induces postoperative immunosuppression and impaired pulmonary function. Maintaining mechanical ventilation (MV) during CPB improves function diminishes systemic inflammation. However, there are no data about the influence of maintaining MV on immune dysfunction.Fifty patients were prospectively divided into two groups: without (n = 25) dead space positive end-expiratory pressure 25). PaO2 (arterial oxygen tension)/FIO2 (inspired fraction)...
Acute respiratory distress syndrome (ARDS) is the main complication of coronavirus disease 2019 (COVID-19), requiring admission to intensive care unit (ICU). Despite extensive immune profiling COVID-19 patients, what extent COVID-19-associated ARDS differs from other causes remains unknown. To address this question, here, we build 3 cohorts patients categorized in COVID-19-ARDS+, COVID-19+ARDS+, and COVID-19+ARDS-, compare, by high-dimensional mass cytometry, their landscape. A cell...
Cardiopulmonary bypass (CPB) during cardiac surgery mechanically circulates and oxygenates the blood, bypassing heart lungs. Despite limited evidence, maintaining mechanical ventilation (MV) CPB is recommended, as ventilator strategies may reduce occurrence of postoperative infections. We aimed to determine whether MV for would decrease infections compared with stopping CPB. conducted a multicenter, single-blind, randomized trial among adult patients undergoing scheduled in six hospitals...
Abstract Metabolic and bioenergetic plasticity of immune cells is essential for optimal responses to bacterial infections. AMPK Parkin ubiquitin ligase are known regulate mitochondrial quality control mitophagy that prevents unwanted inflammatory responses. However, it not if this evolutionarily conserved mechanism has been coopted by the host defense eradicate pathogens influence post-sepsis immunosuppression. Parkin, levels, effects activators were investigated in human leukocytes from...
Abstract Background Restoring plasma arginine levels through enteral administration of L-citrulline in critically ill patients may improve outcomes. We aimed to evaluate whether reduced organ dysfunction based on the Sequential Organ Failure Assessment (SOFA) score and affected selected immune parameters mechanically ventilated medical intensive care unit (ICU) patients. Methods A randomized, double-blind, multicenter clinical trial versus placebo for adult under invasive mechanical...
Abstract Staphylococcus aureus is the main bacterial pathogen encountered in mediastinitis after cardiac surgical procedures; it remains a devastating complication with high mortality rate. As neutrophils have primordial role defense against staphylococcus infection and cardiopulmonary bypass (CPB) known to induce immunosuppression, aim of this study was investigate CPB impact on neutrophil functions. Patients without immunosuppression scheduled for surgery were included. Bone marrow blood...
Abstract The sustained immunosuppression associated with severe sepsis favors an increased susceptibility to secondary infections and remains incompletely understood. Plasmablast plasma cell subsets, whose primary function is secrete antibodies, have emerged as important suppressive populations that expand during sepsis. In particular, supports CD39 hi plasmablast metabolic reprogramming adenosine‐mediated activity. Arginine deficiency has been linked risk of in Overcoming arginine shortage...
ABSTRACT Cardiac surgery with cardiopulmonary bypass (CPB) is associated an immune paresis that predisposes to the development of postoperative infections and sepsis. Among factors responsible for CPB-induced immunosuppression, circulating myeloid-derived suppressor cells (MDSCs) have been found induce early lymphocyte apoptosis proliferation inhibition. However, mechanisms involved are not fully understood. In this study, we main subsets decreased significantly 24 h after cardiac CBP. As...
Abstract Critically ill patients admitted to the intensive care unit (ICU) for SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) are at increased risk of bacterial and fungal secondary pulmonary infections due acquired immune dysfunction. Given that activity neutrophils has not been described in these patients, we aimed investigate function ICU admission on day 7 (D7) postadmission. Neutrophil maturation several functional indicators were investigated. We detected a significant...
Background Influenza virus (IV)-related pathophysiology suggests that the prognosis of acute respiratory distress syndrome (ARDS) due to IV could be different from ARDS other causes. However, impact infection alone on patients compared with causes has been poorly assessed. Methods We 28-day survival diagnosis an arterial oxygen tension/inspiratory fraction ratio ≤150 mmHg between and without alone. Data were collected prospectively analysed retrospectively. first performed analysis whole...
Abstract Acute respiratory distress syndrome (ARDS) is the main complication of COVID-19, requiring admission to Intensive Care Unit (ICU). Despite recent immune profiling COVID-19 patients, what extent COVID-19-associated ARDS specifically differs from other causes remains unknown, To address this question, we built 3 cohorts patients categorized in neg pos , and compared their landscape analyzed by high-dimensional mass cytometry on peripheral blood followed artificial intelligence...