A5090291825- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Hemoglobinopathies and Related Disorders
- Blood transfusion and management
- Antifungal resistance and susceptibility
- Protein Degradation and Inhibitors
- Blood groups and transfusion
- Renal Transplantation Outcomes and Treatments
- Pluripotent Stem Cells Research
- Cancer Treatment and Pharmacology
- Immunodeficiency and Autoimmune Disorders
- Blood properties and coagulation
- Polyomavirus and related diseases
- Erythrocyte Function and Pathophysiology
- Cytomegalovirus and herpesvirus research
- Fungal Infections and Studies
- Prenatal Screening and Diagnostics
Centre National de la Recherche Scientifique
2013-2024
Centre Hospitalier Universitaire de Grenoble
2013-2024
Université Grenoble Alpes
2009-2024
Hôpital Albert Michallon
2006-2020
Agence de la Biomédecine
2005-2019
Institut pour l'avancée des biosciences
1998-2018
Inserm
1996-2018
Translational Innovation in Medicine and Complexity
2013-2018
Établissement Français du Sang
2007-2018
Institut polytechnique de Grenoble
2017
Abstract Aims Pulsed field ablation (PFA) has been proposed as a novel alternative to radiofrequency (RF) and cryoablation in the treatment of atrial fibrillation (AF). Following occurrence two cases acute kidney injury (AKI) secondary haemolysis after PFA procedure, we evaluated cohort consecutive patients. Methods results Two AKI occurred last May June 2023. was severe procedure. From 2023, total 68 patients (64.3 ± 10.5 years) undergoing AF with were enrolled study. All had blood sample...
The prognostic impact of complete response (CR) achievement in multiple myeloma (MM) has been shown mostly the context autologous stem-cell transplantation. Other levels have defined because, even with high-dose therapy, CR is a relatively rare event. purpose this study was to analyze very good partial (VGPR) patients treated therapy.All were included Intergroupe Francophone du Myelome 99-02 and 99-04 trials vincristine, doxorubicin, dexamethasone (VAD) induction therapy followed by double...
ABSTRACT The effectiveness of galactomannan detection with the Platelia test was evaluated in a prospective study 3,327 sera from 807 patients. specificity 99.6% (748 751 cases). For groups patients proven and probable invasive aspergillosis, sensitivity 50.0% (17 34 disappointing associated presence rare false-positive cases underlines limits this test.
The biological diagnosis of toxoplasmosis after allogeneic hematopoietic stem cell transplantation (HSCT) is based on the detection Toxoplasma gondii DNA in blood specimens or other samples. Serological testing used mainly to define immunity status patient before HSCT. aim our study was examine performance polymerase chain reaction (PCR) and serological techniques HSCT.Seventy patients underwent HSCT from September 2004 through 2006. detected by PCR, immunoglobulin G M were enzyme-linked...
Pathogen reduction of platelet concentrates may reduce transfusion-transmitted infections but is associated with qualitative impairment, which could have clinical significance regard to hemostatic capacity.
// Tomasz Czerw 1 , Myriam Labopin 2,3,4 Christoph Schmid 5 Jan J. Cornelissen 6 Patrice Chevallier 7 Didier Blaise 8 Jürgen Kuball 9 Stephane Vigouroux 10 Frédéric Garban 11 Bruno Lioure 12 Nathalie Fegueux 13 Laurence Clement 14 Anna Sandstedt 15 Johan Maertens 16 Gaëlle Guillerm 17 Dominique Bordessoule 18 Mohamad Mohty 2,3,4,* and Arnon Nagler 19,2,* Department of Bone Marrow Transplantation Oncohematology, Maria Sklodowska-Curie Memorial Cancer Centre Institute Oncology, Gliwice Branch,...
Background and Objectives High-dose chemotherapy with allogeneic stem cell transplantation (SCT) has proven to be a successful treatment for low-grade lymphoma (LGL), but is associated considerable transplant-related mortality (TRM). In an effort reduce toxic while maintaining the graft-versus-leukemia effect, SCT been combined reduced-intensity conditioning (RIC) regimen. The aim of this study was determine outcome patients LGL treated RIC SCT.Design Methods This retrospective multicenter...
Background The prognosis of acute lymphoblastic leukemia in the elderly is poor. GRAALL-SA1 phase II, randomized trial compared efficacy and toxicity pegylated liposomal doxorubicin versus continuous-infusion patients 55 years or older with Philadelphia chromosome-negative leukemia.Design Methods Sixty received either (12 mg/m2/day) vincristine (0.4 mg/day) on days 1–4 (40 mg/m2) standard (2 mg) day 1, accompanied by dexamethasone, followed at 28 a second cycle, reinforced cyclophosphamide....
In this retrospective multicentre study, we analysed the results of 82 consecutive second early allogeneic transplants for primary (n = 28) or secondary ([n 54) graft failures performed between 1985 and 1997 in patients with acute leukaemia 33), aplastic anaemia 29) chronic myeloid 20). HLA-matched siblings were used 64 cases. The same donors both 56 cases first transplant was T-cell depleted 30 median age at 25 years intertransplant time interval 2 months. Estimates 3-year overall survival...
To analyze the impact of pre- and posttransplantation factors on outcome allogeneic transplantation after nonmyeloablative conditioning regimens.Ninety-two transplantations preparative regimens were reported to Société Française de Greffe Moelle Registry registry. Initial diagnoses lymphoid diseases (n = 22), myeloma 14), acute leukemia myelodysplasia 41), chronic myelogenous 12), solid tumors 3). Forty-six patients had previously received a transplant, 49 progressive disease before...
In this retrospective multicentre study, we analysed the results of 82 consecutive second early allogeneic transplants for primary ( n = 28) or secondary 54) graft failures performed between 1985 and 1997 in patients with acute leukaemia 33), aplastic anaemia 29) chronic myeloid 20). HLA‐matched siblings were used 64 cases. The same donors both 56 cases first transplant was T‐cell depleted 30 median age at 25 years intertransplant time interval 2 months. Estimates 3‐year overall survival day...
The role of reduced intensity allogeneic stem cell transplantation for the treatment relapsed/refractory Hodgkin's lymphoma remains controversial. We retrospectively analyzed 191 patients who underwent between 1998 and 2008 relapsed or refractory whose data were reported to French registry. median follow-up was 36 months. estimated 3-year overall survival rate, progression-free cumulative incidence relapse non-relapse mortality 63%, 39%, 46%, 16%, respectively. There no difference in outcome...
Superoxide-mediated clastogenesis is characteristic for various chronic inflammatory diseases with autoimmune reactions and probably plays a role in radiation-induced the congenital breakage syndromes. It consistently prevented by exogenous superoxide dismutase (SOD), but not heat-inactivated SOD, indicating that anticlastogenic effect related to catalytic function of enzyme. Increased production activated monocytes/macrophages followed release more long-lived metabolites, so-called...