A5057415884- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Parasitic Infections and Diagnostics
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Rabies epidemiology and control
- Medical Device Sterilization and Disinfection
- Indoor Air Quality and Microbial Exposure
- Pneumocystis jirovecii pneumonia detection and treatment
- Plant Pathogens and Fungal Diseases
- Mosquito-borne diseases and control
- Sex work and related issues
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Parasitic Diseases Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dermatological diseases and infestations
- Infectious Diseases and Mycology
- Insects and Parasite Interactions
- Malaria Research and Control
- Viral Infections and Vectors
- Legionella and Acanthamoeba research
- Neonatal Health and Biochemistry
Université Grenoble Alpes
2016-2025
Inserm
2016-2025
Unit of Virus Host Cell Interactions
2002-2025
Centre Hospitalier Universitaire de Grenoble
2015-2024
Centre National de la Recherche Scientifique
2014-2023
Institut pour l'avancée des biosciences
2016-2023
Institut de Biosciences et Biotechnologies
2017-2022
Laboratoire Rhéologie et Procédés
2008-2020
Grenoble Institute of Neurosciences
2020
Université Joseph Fourier
2002-2015
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, actively remodels transcriptome its hosting cells with profound and coupled impact on host immune response. We report secretes GRA24, novel dense granule protein which traffics from vacuole to cell nucleus. Once released into cell, GRA24 has unique ability trigger prolonged autophosphorylation nuclear translocation p38α MAP...
An early hallmark of Toxoplasma gondii infection is the rapid control parasite population by a potent multifaceted innate immune response that engages resident and homing cells along with pro- counter-inflammatory cytokines. In this context, IFN-γ activates variety T. gondii–targeting activities in nonimmune but can also contribute to host pathology. has evolved mechanisms timely counteract defenses interfering transcription IFN-γ–stimulated genes. We now have identified TgIST (T. inhibitor...
Abstract Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes hematopoietic stem cell transplant (HSCT) solid organ (SOT; heart, kidney, or liver) in Europe. collected electronic data on the population guidelines/regulations clinical cases diagnosed during 2010–2014. Serologic pretransplant screening allo-hematopoietic donors was performed 80% countries, 100%. SOT...
ABSTRACT Toxoplasmosis is a life-threatening infection in immunocompromised patients (ICPs). The definitive diagnosis relies on parasite DNA detection, but little known about the incidence and burden of disease HIV-negative patients. A 3-year retrospective study was conducted 15 reference laboratories from network French National Reference Center for Toxoplasmosis, order to record frequency Toxoplasma gondii detection ICPs review molecular methods used prevention measures implemented...
The biological diagnosis of toxoplasmosis after allogeneic hematopoietic stem cell transplantation (HSCT) is based on the detection Toxoplasma gondii DNA in blood specimens or other samples. Serological testing used mainly to define immunity status patient before HSCT. aim our study was examine performance polymerase chain reaction (PCR) and serological techniques HSCT.Seventy patients underwent HSCT from September 2004 through 2006. detected by PCR, immunoglobulin G M were enzyme-linked...
microRNAs were recently found to be regulators of the host response infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that coinduced in brains mice challenged with Toxoplasma a strain-specific manner. These define characteristic fingerprint for type II strains, which are most prevalent cause human toxoplasmosis Europe North America. Using forward genetics, showed differences modulation part mediated rhoptry kinase, ROP16....
The intracellular parasite Toxoplasma gondii, hijacks evolutionarily conserved host processes by delivering effector proteins into the cell that shift gene expression in a timely fashion. We identified dense granule protein as GRA18 once released cytoplasm forms versatile complexes with regulatory elements of β-catenin destruction complex. By interacting GSK3/PP2A-B56, drives up-regulation and downstream effects on expression. In context macrophages infection, induces specific set genes...
Research Article1 February 2017Open Access Transparent process Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis Andrés Palencia Corresponding Author [email protected] orcid.org/0000-0002-1805-319X Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions & Immunity Infection, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Grenoble, France European Molecular Biology Laboratory (EMBL), Outstation and Unit of Virus Host-Cell Interactions,...
Although screening for maternal toxoplasmic seroconversion during pregnancy is based on immunodiagnostic assays, the diagnosis of clinically relevant toxoplasmosis greatly relies upon molecular methods. A problem that this subject to variation performances, mainly due a large diversity PCR methods and primers lack standardization. The present multicentric prospective study, involving eight laboratories proficient in prenatal toxoplasmosis, was first step toward harmonization among university...
Our objective was to investigate characteristics risk factors and outcomes of patients with chronic pulmonary aspergillosis (CPA).The Aspergillosis Committee prospectively collected Aspergillus notifications from January 2000 December 2011. A retrospective analysis data performed.Among 1614 registered, 44 cases CPA in non-immunocompromised were identified. The median age 65 years (Q1-Q3: 54-75), the body mass index (BMI) 20 kg/m(2) 16-22) 15 had obstructive disease. All a positive specific...
Bradyzoite-to-tachyzoite conversion plays a role in the pathogenesis of recrudescence ocular toxoplasmosis and disease immunocompromised persons. The currently available medicines are ineffective on cysts fail to prevent reactivation latent toxoplasmosis. A previous study showed that histone deacetylase inhibitor FR235222 has dramatic effect tachyzoite growth induces tachyzoite-to-bradyzoite vitro. present shows can target vitro-converted bradyzoites. Moreover, compound is active ex vivo T....
Serological testing to detect toxoplasmosis is of major importance avoid the possible effects disease in newborns. This study assessed anti-Toxoplasma IgG and IgM with Vidas (bioMérieux), Architect (Abbott), Liaison (DiaSorin) systems 631 sera from pregnant women newborns as well avidity these three on 54 positive IgM. The results were agreement in, respectively, 95.2% 98.3% (Vidas versus Architect) 96.9% 95.3% Liaison) samples. Specificities excellent for all assays, while sensitivities...
Anti-Aspergillus IgG antibodies are important biomarkers for the diagnosis of chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary (ABPA). We compared performance a new commercial enzyme immunoassay (EIA) (Bordier Affinity Products) with that Bio-Rad Virion\Serion EIAs. This assay is novel in its association two recombinant antigens somatic metabolic Aspergillus fumigatus In prospective multicenter study, 436 serum samples from 147 patients diagnosed CPA (136 samples/104...
The Apicomplexa comprise a large phylum of single-celled, obligate intracellular protozoa that include Toxoplasma gondii , Plasmodium and Cryptosporidium spp., which infect humans animals cause severe parasitic diseases. Available therapeutics against these diseases are limited by suboptimal efficacy frequent side effects, as well the emergence spread resistance. We use drug repurposing strategy identify altiratinib, compound originally developed to treat glioblastoma, promising candidate...