Nicolas Allou

ORCID: 0000-0002-3228-0831
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About
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Research Areas
  • Antibiotic Resistance in Bacteria
  • Nosocomial Infections in ICU
  • Sepsis Diagnosis and Treatment
  • Pneumonia and Respiratory Infections
  • Mechanical Circulatory Support Devices
  • Cardiac Arrest and Resuscitation
  • Antibiotics Pharmacokinetics and Efficacy
  • COVID-19 Clinical Research Studies
  • Travel-related health issues
  • Antibiotic Use and Resistance
  • Long-Term Effects of COVID-19
  • Cardiac, Anesthesia and Surgical Outcomes
  • Cardiac Valve Diseases and Treatments
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Acute Myocardial Infarction Research
  • Respiratory Support and Mechanisms
  • SARS-CoV-2 and COVID-19 Research
  • Atrial Fibrillation Management and Outcomes
  • Mosquito-borne diseases and control
  • Leptospirosis research and findings
  • Infective Endocarditis Diagnosis and Management
  • Cardiac Structural Anomalies and Repair
  • Vibrio bacteria research studies
  • Antimicrobial Resistance in Staphylococcus
  • Infections and bacterial resistance

Centre Hospitalier Universitaire de La Réunion
2016-2025

Centre Hospitalier Saint-Denis
2016-2024

Hôpital Pontchaillou
2024

National Heart Institute
2024

Université Félix Houphouët-Boigny
2021-2023

Université Paris 8
2023

Département d'Informatique
2018-2022

Centre Hospitalier Universitaire de Rennes
2022

Chongqing Electromechanical Holdings (China)
2022

Université de Rennes
2022

The aims of this study were, first, to identify risk factors for microbiology-proven postoperative pneumonia after cardiac surgery and, second, develop and validate a preoperative scoring system the pneumonia. A single-center cohort study. All consecutive patients undergoing between January 2006 July 2011. None. Multivariate analysis was performed on data from operated December 2008 (training set). External temporal validation 2009 2011 (validation Preoperative variables identified in...

10.1097/ccm.0000000000000143 article EN Critical Care Medicine 2013-12-18

Background Despite expanding use, knowledge on extracorporeal membrane oxygenation support during the COVID-19 pandemic remains limited. The objective was to report characteristics, management, and outcomes of patients receiving with a diagnosis in France identify pre-extracorporeal factors associated in-hospital mortality. A hypothesis similar mortality rates risk for non–COVID-19 venovenous made. Methods Extracorporeal Membrane Oxygenation Respiratory Failure and/or Heart failure related...

10.1097/aln.0000000000004168 article EN Anesthesiology 2022-03-29

We investigated the impact of low-level resistance to fluoroquinolones on bactericidal activity ciprofloxacin in a murine model urinary tract infection. The susceptible Escherichia coli strain CFT073 (ciprofloxacin MIC [CIP MIC] 0.008 microg/ml) was compared its transconjugants harboring qnrA1 or qnrS1 and an S83L gyrA mutant. three derivatives showed similar (CIP MICs, 0.25 0.5 microg/ml). Bactericidal measured vitro after 1, 3, 6 h exposure microg/ml significantly lower for derivative...

10.1128/aac.01664-08 article EN Antimicrobial Agents and Chemotherapy 2009-07-28

Background Iron deficiency is the commonest cause of anaemia. It apparent preoperatively in cardiac surgery patients and may influence transfusion requirements. In addition, iron per se associated with fatigue. Objective To determine prevalence preoperative its association perioperative anaemia, blood transfusions fatigue patients. Setting Academic hospital Paris, France. Patients One hundred consecutive without known disorder scheduled for were prospectively included this observational...

10.1097/eja.0b013e32834ad97b article EN European Journal of Anaesthesiology 2011-10-04

Little is known about cannula-related infection (CRI) in patients supported by extracorporeal membrane oxygenation (ECMO). The aim of this study was to assess the incidence, risk factors, prognosis, and microbiological characteristics CRI ECMO. This retrospective cohort conducted one intensive care unit (ICU). Among 220 consecutive with peripheral ECMO, 39 (17.7%) developed CRI. incidence 17.2 per 1,000 ECMO days. main isolated microorganisms were Enterobacteriaceae (38%), Staphylococcus...

10.1097/mat.0000000000000771 article EN ASAIO Journal 2018-03-06

De-escalation is strongly recommended for antibiotic stewardship. No studies have addressed this issue in the context of health care-associated intra-abdominal infections (HCIAI). We analyzed factors that could interfere with process and their clinical consequences intensive care unit (ICU) patients HCIAI.All consecutive admitted management HCIAI who survived more than 3 days following diagnosis, remained ICU days, did not undergo early reoperation during first were prospectively an...

10.1186/s13054-016-1267-8 article EN cc-by Critical Care 2016-03-31

Persistent peritonitis is a frequent complication of secondary requiring additional reoperations and antibiotic therapy. This situation raises specific concerns due to microbiological changes in peritoneal samples, especially the emergence multidrug-resistant (MDR) strains. Although this has been extensively studied, rate dynamics MDR strains have rarely analysed.We compared clinical, therapeutic data consecutive ICU patients admitted for postoperative either without subsequent reoperation...

10.1186/s13054-015-0789-9 article EN cc-by Critical Care 2015-02-19

Few data are available on the impact of levosimendan in refractory cardiogenic shock patients undergoing peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO). The aim this study was to evaluate VA-ECMO weaning hospitalized intensive care unit (ICU).This retrospective cohort conducted a French university hospital from 2010 2017. All ICU were consecutively evaluated.A total 150 eligible for study. Thirty-eight propensity-matched evaluated group and 65 non-levosimendan group....

10.1186/s13613-019-0503-1 article EN cc-by Annals of Intensive Care 2019-02-01

Leptospirosis causes reversible multiple organ failure, and its mortality remains high. The aim of this study was to determine the rate leptospirosis in an ICU offering all types support available nowadays compare it with bacterial sepsis.Retrospective, descriptive, single-center cohort study.The largest Reunion Island (Indian Ocean) a teaching hospital.Consecutive patients hospitalized for from January 2004 2015.None.We report 134 cases ICU. median age 40 years (interquartile range, 30-52...

10.1097/ccm.0000000000002825 article EN Critical Care Medicine 2017-11-07

Metabolic disorders and fluid overload are indications of continuous renal replacement therapy (CRRT) including venovenous hemofiltration in patients on extracorporeal membrane oxygenation (ECMO). Direct connection CRRT machine to the ECMO circuit provides many advantages. Nevertheless, because pressures lines relate blood flow, high flow may be associated with lines. Thus, management pressure becomes challenging. We evaluated a protocol for managing pressures. Connections were performed...

10.1097/mat.0000000000000441 article EN ASAIO Journal 2016-09-23

Background End-of-life decision-making in Intensive care Units (ICUs) is difficult. The main problems encountered are the lack of a reliable prediction score for death and fact that opinion patients rarely taken into consideration. Decision Curve Analysis (DCA) recent method developed to evaluate models which takes account wishes (or surrogates) expose themselves risk obtaining false result. Our objective was clinical usefulness, with DCA, Simplified Acute Physiology Score II (SAPS II)...

10.1371/journal.pone.0164828 article EN cc-by PLoS ONE 2016-10-14

Few national recommendations exist on management of patients returning from abroad and all focus hospitalized patients. Our purpose was to compare, in an intensive care unit (ICU), the admission prevalence acquisition multidrug-resistant (MDR) bacteria carriage with ("Abroad") or without ("Local") a recent stay abroad, then identify risk factors "Abroad" patients.In this retrospective study, we reviewed charts ICU January 2011 through July 2013 hygiene samplings performed. We identified who...

10.1111/jtm.12220 article EN Journal of Travel Medicine 2015-06-17

The therapeutic effect of aminoglycosides is highest and optimal when the peak plasma concentration (C max)/minimal inhibitory (MIC) ratio between 8 10. French guidelines recommend to use high doses for empiric antibiotic therapy in patients suffering from severe sepsis or septic shock. In clinical practice, recommended target an amikacin C max 60 80 mg/L, which corresponds approximately times MIC breakpoint, as defined by European Committee on Antimicrobial Susceptibility Testing. aim this...

10.1186/s13613-016-0211-z article EN cc-by Annals of Intensive Care 2016-11-02

No studies have compared ventilator-associated pneumonia (VAP) and non-VAP following cardiac surgery (CS). The aim of this study was to assess the incidence, clinical microbiologic features, treatment characteristics prognosis postoperative CS with a special focus on non-VAP.This retrospective cohort based prospectively collected database. We cases VAP observed between January 2005 December 2012. Statistical analysis consisted bivariate multivariate analysis.A total 257 (3.5%) 7,439...

10.1186/s13054-015-0845-5 article EN cc-by Critical Care 2015-03-10

Acinetobacter baumannii (Ab) is a well-known nosocomial pathogen that has emerged as cause of community-acquired pneumonia (CAP) in tropical regions. Few global epidemiological studies CAP-Ab have been published to date, and no data are available on this disease France. We conducted retrospective chart review severe cases admitted intensive care units Réunion University Hospital between October 2014 2022. Eight were reviewed. Median patient age was 56.5 years. Sex ratio (male-to-female) 3:1....

10.4269/ajtmh.23-0820 article EN cc-by American Journal of Tropical Medicine and Hygiene 2024-06-04

Abstract Background Anecdotal evidence suggests that early renal replacement therapy (RRT) may improve the mortality associated with acute kidney injury (AKI) in patients leptospirosis. Conversely, several randomized controlled trials (RCTs) conducted intensive care units have refuted positive impact of RRT on AKI and other causes sepsis. Methods In this emulated RCT utilizing a propensity score-weighted logistic regression performed two academic centers island La Réunion, France, between...

10.1186/s13613-025-01477-5 article EN cc-by Annals of Intensive Care 2025-05-14

The widespread presence of plasmid-mediated quinolone resistance determinants, particularly qnr genes, has become a current issue. By protecting DNA-gyrase from quinolones, Qnr proteins confer low level that is not sufficient to explain their emergence. Since were hypothesized act as DNA-binding protein regulators, genes could have emerged by providing selective advantage other than antibiotic resistance. We investigated host fitness Escherichia coli isogenic strains after acquisition the...

10.1371/journal.pone.0024552 article EN cc-by PLoS ONE 2011-09-07

Abstract Background The spread of carbapenemase-producing Enterobacteriaceae (CPE) in the Southwest Indian Ocean area (SIOA) is poorly documented. Reunion Island a French overseas territory located close to Madagascar and connected with Southern Africa, sub-continent Europe, several weekly flights. Here we report results CPE surveillance program over six-year period. Methods All were collected between January 2011 December 2016. Demographics clinical data carrier patients collected. We...

10.1186/s13756-020-0703-3 article EN cc-by Antimicrobial Resistance and Infection Control 2020-02-19
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