A5085404520- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
- Travel-related health issues
- Antibiotic Use and Resistance
- Long-Term Effects of COVID-19
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Acute Myocardial Infarction Research
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Atrial Fibrillation Management and Outcomes
- Mosquito-borne diseases and control
- Leptospirosis research and findings
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Vibrio bacteria research studies
- Antimicrobial Resistance in Staphylococcus
- Infections and bacterial resistance
Centre Hospitalier Universitaire de La Réunion
2016-2025
Centre Hospitalier Saint-Denis
2016-2024
Hôpital Pontchaillou
2024
National Heart Institute
2024
Université Félix Houphouët-Boigny
2021-2023
Université Paris 8
2023
Département d'Informatique
2018-2022
Centre Hospitalier Universitaire de Rennes
2022
Chongqing Electromechanical Holdings (China)
2022
Université de Rennes
2022
The aims of this study were, first, to identify risk factors for microbiology-proven postoperative pneumonia after cardiac surgery and, second, develop and validate a preoperative scoring system the pneumonia. A single-center cohort study. All consecutive patients undergoing between January 2006 July 2011. None. Multivariate analysis was performed on data from operated December 2008 (training set). External temporal validation 2009 2011 (validation Preoperative variables identified in...
Background Despite expanding use, knowledge on extracorporeal membrane oxygenation support during the COVID-19 pandemic remains limited. The objective was to report characteristics, management, and outcomes of patients receiving with a diagnosis in France identify pre-extracorporeal factors associated in-hospital mortality. A hypothesis similar mortality rates risk for non–COVID-19 venovenous made. Methods Extracorporeal Membrane Oxygenation Respiratory Failure and/or Heart failure related...
We investigated the impact of low-level resistance to fluoroquinolones on bactericidal activity ciprofloxacin in a murine model urinary tract infection. The susceptible Escherichia coli strain CFT073 (ciprofloxacin MIC [CIP MIC] 0.008 microg/ml) was compared its transconjugants harboring qnrA1 or qnrS1 and an S83L gyrA mutant. three derivatives showed similar (CIP MICs, 0.25 0.5 microg/ml). Bactericidal measured vitro after 1, 3, 6 h exposure microg/ml significantly lower for derivative...
Background Iron deficiency is the commonest cause of anaemia. It apparent preoperatively in cardiac surgery patients and may influence transfusion requirements. In addition, iron per se associated with fatigue. Objective To determine prevalence preoperative its association perioperative anaemia, blood transfusions fatigue patients. Setting Academic hospital Paris, France. Patients One hundred consecutive without known disorder scheduled for were prospectively included this observational...
Little is known about cannula-related infection (CRI) in patients supported by extracorporeal membrane oxygenation (ECMO). The aim of this study was to assess the incidence, risk factors, prognosis, and microbiological characteristics CRI ECMO. This retrospective cohort conducted one intensive care unit (ICU). Among 220 consecutive with peripheral ECMO, 39 (17.7%) developed CRI. incidence 17.2 per 1,000 ECMO days. main isolated microorganisms were Enterobacteriaceae (38%), Staphylococcus...
De-escalation is strongly recommended for antibiotic stewardship. No studies have addressed this issue in the context of health care-associated intra-abdominal infections (HCIAI). We analyzed factors that could interfere with process and their clinical consequences intensive care unit (ICU) patients HCIAI.All consecutive admitted management HCIAI who survived more than 3 days following diagnosis, remained ICU days, did not undergo early reoperation during first were prospectively an...
Persistent peritonitis is a frequent complication of secondary requiring additional reoperations and antibiotic therapy. This situation raises specific concerns due to microbiological changes in peritoneal samples, especially the emergence multidrug-resistant (MDR) strains. Although this has been extensively studied, rate dynamics MDR strains have rarely analysed.We compared clinical, therapeutic data consecutive ICU patients admitted for postoperative either without subsequent reoperation...
Few data are available on the impact of levosimendan in refractory cardiogenic shock patients undergoing peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO). The aim this study was to evaluate VA-ECMO weaning hospitalized intensive care unit (ICU).This retrospective cohort conducted a French university hospital from 2010 2017. All ICU were consecutively evaluated.A total 150 eligible for study. Thirty-eight propensity-matched evaluated group and 65 non-levosimendan group....
Leptospirosis causes reversible multiple organ failure, and its mortality remains high. The aim of this study was to determine the rate leptospirosis in an ICU offering all types support available nowadays compare it with bacterial sepsis.Retrospective, descriptive, single-center cohort study.The largest Reunion Island (Indian Ocean) a teaching hospital.Consecutive patients hospitalized for from January 2004 2015.None.We report 134 cases ICU. median age 40 years (interquartile range, 30-52...
Metabolic disorders and fluid overload are indications of continuous renal replacement therapy (CRRT) including venovenous hemofiltration in patients on extracorporeal membrane oxygenation (ECMO). Direct connection CRRT machine to the ECMO circuit provides many advantages. Nevertheless, because pressures lines relate blood flow, high flow may be associated with lines. Thus, management pressure becomes challenging. We evaluated a protocol for managing pressures. Connections were performed...
Background End-of-life decision-making in Intensive care Units (ICUs) is difficult. The main problems encountered are the lack of a reliable prediction score for death and fact that opinion patients rarely taken into consideration. Decision Curve Analysis (DCA) recent method developed to evaluate models which takes account wishes (or surrogates) expose themselves risk obtaining false result. Our objective was clinical usefulness, with DCA, Simplified Acute Physiology Score II (SAPS II)...
Few national recommendations exist on management of patients returning from abroad and all focus hospitalized patients. Our purpose was to compare, in an intensive care unit (ICU), the admission prevalence acquisition multidrug-resistant (MDR) bacteria carriage with ("Abroad") or without ("Local") a recent stay abroad, then identify risk factors "Abroad" patients.In this retrospective study, we reviewed charts ICU January 2011 through July 2013 hygiene samplings performed. We identified who...
The therapeutic effect of aminoglycosides is highest and optimal when the peak plasma concentration (C max)/minimal inhibitory (MIC) ratio between 8 10. French guidelines recommend to use high doses for empiric antibiotic therapy in patients suffering from severe sepsis or septic shock. In clinical practice, recommended target an amikacin C max 60 80 mg/L, which corresponds approximately times MIC breakpoint, as defined by European Committee on Antimicrobial Susceptibility Testing. aim this...
No studies have compared ventilator-associated pneumonia (VAP) and non-VAP following cardiac surgery (CS). The aim of this study was to assess the incidence, clinical microbiologic features, treatment characteristics prognosis postoperative CS with a special focus on non-VAP.This retrospective cohort based prospectively collected database. We cases VAP observed between January 2005 December 2012. Statistical analysis consisted bivariate multivariate analysis.A total 257 (3.5%) 7,439...
Acinetobacter baumannii (Ab) is a well-known nosocomial pathogen that has emerged as cause of community-acquired pneumonia (CAP) in tropical regions. Few global epidemiological studies CAP-Ab have been published to date, and no data are available on this disease France. We conducted retrospective chart review severe cases admitted intensive care units Réunion University Hospital between October 2014 2022. Eight were reviewed. Median patient age was 56.5 years. Sex ratio (male-to-female) 3:1....
Abstract Background Anecdotal evidence suggests that early renal replacement therapy (RRT) may improve the mortality associated with acute kidney injury (AKI) in patients leptospirosis. Conversely, several randomized controlled trials (RCTs) conducted intensive care units have refuted positive impact of RRT on AKI and other causes sepsis. Methods In this emulated RCT utilizing a propensity score-weighted logistic regression performed two academic centers island La Réunion, France, between...
The widespread presence of plasmid-mediated quinolone resistance determinants, particularly qnr genes, has become a current issue. By protecting DNA-gyrase from quinolones, Qnr proteins confer low level that is not sufficient to explain their emergence. Since were hypothesized act as DNA-binding protein regulators, genes could have emerged by providing selective advantage other than antibiotic resistance. We investigated host fitness Escherichia coli isogenic strains after acquisition the...
Abstract Background The spread of carbapenemase-producing Enterobacteriaceae (CPE) in the Southwest Indian Ocean area (SIOA) is poorly documented. Reunion Island a French overseas territory located close to Madagascar and connected with Southern Africa, sub-continent Europe, several weekly flights. Here we report results CPE surveillance program over six-year period. Methods All were collected between January 2011 December 2016. Demographics clinical data carrier patients collected. We...