Marc Pineton de Chambrun
A5075660502- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Mechanical Circulatory Support Devices
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Disorders and Syndromes
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac Arrest and Resuscitation
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Myopathies and Dermatomyositis
- Viral Infections and Immunology Research
- Monoclonal and Polyclonal Antibodies Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Structural Anomalies and Repair
- Muscle and Compartmental Disorders
- Respiratory Support and Mechanisms
- Cytokine Signaling Pathways and Interactions
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Peripheral Neuropathies and Disorders
- SARS-CoV-2 and COVID-19 Research
- Lymphoma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Ocular Diseases and Behçet’s Syndrome
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Inserm
2011-2025
Pitié-Salpêtrière Hospital
2016-2025
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2017-2025
Centre d'Immunologie et des Maladies Infectieuses
2019-2025
Imation (United States)
2022-2025
Université de Lorraine
2025
French Clinical Research Infrastructure Network
2025
Réanimation et soins intensifs du patient en Insuffisance respiratoire aigüe
2022-2024
In the Île-de-France region (henceforth termed Greater Paris), extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) was considered early in COVID-19 pandemic. We report ECMO network organisation and outcomes during first wave of pandemic.In this multicentre cohort study, we present an analysis all adult patients with laboratory-confirmed SARS-CoV-2 infection ARDS requiring who were admitted to 17 Paris intensive care units between March 8 June 3,...
Immune-checkpoint-inhibitor (ICI)-associated myotoxicity involves the heart (myocarditis) and skeletal muscles (myositis), which frequently occur concurrently are highly fatal. We report results of a strategy that included identification individuals with severe ICI myocarditis by also screening for managing concomitant respiratory muscle involvement mechanical ventilation, as well treatment CTLA4 fusion protein abatacept JAK inhibitor ruxolitinib. Forty cases definite were pathologic...
In most patients with nonsevere systemic necrotizing vasculitides (SNVs), remission is achieved glucocorticoids alone, but one-third experience a relapse within 2 years. This study was undertaken to determine whether the addition of azathioprine (AZA) could achieve higher sustained rate newly diagnosed eosinophilic granulomatosis polyangiitis (Churg-Strauss) (EGPA), microscopic (MPA), or polyarteritis nodosa (PAN).All included in this double-blind trial received glucocorticoids, gradually...
The data on incidence, clinical presentation, and outcomes of ventilator-associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) requiring mechanical ventilation (MV) are limited. We performed this retrospective cohort study to assess frequency, characteristics, responsible pathogens, VAP COVID-19 MV between March 12th April 24th, 2020 (all had RT-PCR-confirmed SARS-CoV-2 infection). Patients COVID-19-associated acute respiratory distress syndrome (ARDS) ECMO...
To compare the efficacy to prevent flares of maintenance versus withdrawal 5 mg/day prednisone in systemic lupus erythematosus (SLE) patients with clinically quiescent disease. A monocentric, 12-month, superiority, open-label, randomised (1:1) controlled trial was conducted 61 continuing and 63 stopping it. Eligibility criteria were SLE who, during year preceding inclusion, had a inactive disease stable treatment including prednisone. The primary endpoint proportion patient experiencing...
Coronavirus disease 2019 (COVID-19) is associated with a systemic coagulopathy 1 favoring thromboembolic complications, which occur in 15% to 30% of critically ill patients COVID-19. 2,3This remains poorly documented and data on thrombin generation fibrinolysis are lacking.We characterized the coagulation profiles CO-VID-19 acute respiratory distress syndrome (ARDS).From October April 2020, 28 consecutive severe ARDS were referred our tertiary intensive care unit included this prospective...
Anti-synthetase (AS) and dermato-pulmonary associated with anti-MDA-5 antibodies (aMDA-5) syndromes are near one of the other autoimmune inflammatory myopathies potentially responsible for severe acute interstitial lung disease. We undertook a 13-year retrospective multicenter study in 35 French ICUs order to describe clinical presentation outcome patients admitted ICU respiratory failure (ARF) revealing AS or aMDA-5 syndromes.From 2005 2017, 47 (23 males; median age 60 [1st-3rd quartiles...
Extracorporeal membrane oxygenation (ECMO) was frequently used to treat patients with severe coronavirus disease-2019 (COVID-19)-associated acute respiratory distress (ARDS) during the initial outbreak. Care of COVID-19 evolved markedly second part 2020. Our objective compare characteristics and outcomes who received ECMO for ARDS before or after July 1, We included consecutive adults diagnosed in Paris-Sorbonne University Hospital Network ICUs, until January 28, 2021. Characteristics...
Recent multicenter studies identified COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large study has compared the incidence of IPA between and influenza patients.To determine putative in critically ill SARS-CoV-2 patients, with patients.This was planned ancillary analysis coVAPid retrospective European cohort. Consecutive adult patients requiring mechanical ventilation > 48 h pneumonia or were included. The 28-day cumulative IPA, based on Blot definition,...
Prone positioning (PP) reduces mortality of patients with acute respiratory distress syndrome (ARDS). The potential benefit prone maneuvers during venovenous extracorporeal membrane oxygenation (ECMO) is unknown. aim this study was to evaluate the association between use support and ICU in a pooled population from previous European cohort studies.We performed individual patient data analysis studies which compared treated ECMO (Prone group) "conventional" management (Supine severe ARDS.889...
Abstract Background Fulminant myocarditis (FM) is a severe condition primarily triggered by viruses. Anti-RNA polymerase III autoantibodies (RNApol3) which are typically found in patients with systemic sclerosis, have been reported influenza-related FM. Our objective to provide additional insight into RNApol3-associated Methods We retrospectively included all admitted our institution between January 2013 and June 2023 acute positive serum RNApol3. compared their characteristics, etiologies,...
Abstract Background Preliminary evidence from small, single-center studies suggests levosimendan may improve the likelihood of successful venoarterial extracorporeal membrane oxygenation (VA-ECMO) weaning in patients with cardiogenic shock. However, literature is limited and presents conflicting results. We aimed to assess benefits on VA-ECMO for time ECMO weaning, using a pragmatic rigorous definition potential cardiac function recovery. Methods A retrospective bicentric study over 6 years...
Behcet's disease (BD) is a well-known cause of Budd-Chiari syndrome (BCS). Data are lacking on the presentation and outcome BCS related to BD. We investigated relationship between BD in 14 patients with both diseases compared results 92 without Male gender (p = 0.003), North African origin (P 0.007) inferior vena cava obstruction < 0.0001) were more frequent than those alone plasma C-reactive protein level was higher 0.003). Two combined underwent recanalization hepatic veins, none received...
Maintenance of remission has become central in the management systemic lupus erythematosus (SLE). The importance interferon-alpha (IFN-α) pathogenesis SLE notwithstanding, its expression been poorly studied as yet. To study and prognostic value prediction a disease relapse, serum IFN-α levels were determined using an ultrasensitive single-molecule array digital immunoassay which enables measurement cytokines at physiological concentrations.A total 254 patients remission, according to...
Objective: Systemic capillary-leak syndrome is a very rare cause of recurrent hypovolemic shock. Few data are available on its clinical manifestations, laboratory findings, and outcomes those patients requiring ICU admission. This study was undertaken to describe the pictures management severe systemic episodes. Design, Setting, Patients: multicenter retrospective analysis concerned entered in European Clarkson’s disease (EurêClark) Registry admitted ICUs between May 1992 February 2016....
No simple or standardized assay is available to quantify interferon-α (IFNα) in routine clinical practice. Single-molecule array (Simoa) digital enzyme-linked immunosorbent (ELISA) technology enables direct IFNα quantification at attomolar (femtogram per milliliter [fg/ml]) concentrations. This study was undertaken assess ELISA diagnostic performances monitor systemic lupus erythematosus (SLE) activity. concentrations serum samples from 150 consecutive SLE patients a cross-sectional were...