Pierre Bay
A5089994053- Eosinophilic Disorders and Syndromes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mechanical Circulatory Support Devices
- Inflammatory Myopathies and Dermatomyositis
- Nosocomial Infections in ICU
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- Immunodeficiency and Autoimmune Disorders
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Antifungal resistance and susceptibility
- SARS-CoV-2 and COVID-19 Research
- Blood groups and transfusion
- Infective Endocarditis Diagnosis and Management
- Vasculitis and related conditions
- Cardiac Arrest and Resuscitation
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Cardiac Structural Anomalies and Repair
- Hemoglobinopathies and Related Disorders
- Eosinophilic Esophagitis
- Blood disorders and treatments
Assistance Publique – Hôpitaux de Paris
2019-2025
Centre Hospitalier Universitaire Henri-Mondor
2024-2025
Hôpitaux Universitaires Henri-Mondor
2022-2025
Inserm
2023-2025
Université Paris-Est Créteil
2023-2025
Institut Mondor de Recherche Biomédicale
2024-2025
Hôpital Albert-Chenevier
2023
Université Gustave Eiffel
2023
Sorbonne Université
2019-2023
Hôpital Tenon
2021-2023
In the Île-de-France region (henceforth termed Greater Paris), extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) was considered early in COVID-19 pandemic. We report ECMO network organisation and outcomes during first wave of pandemic.In this multicentre cohort study, we present an analysis all adult patients with laboratory-confirmed SARS-CoV-2 infection ARDS requiring who were admitted to 17 Paris intensive care units between March 8 June 3,...
Abstract Background Respiratory syncytial virus (RSV) is one of the deadliest respiratory viruses. There a need to better identify prognostic factors in RSV-infected patients, particularly those requiring intensive care unit (ICU) admission, with focus on immunosuppressed patients. Methods Multicenter, retrospective cohort study adults hospitalized 17 ICUs Great Paris area between 08/01/2017 and 05/01/2023. The primary endpoint was all cause day 30 mortality. Supervised unsupervised analyses...
Abstract Background Fulminant myocarditis (FM) is a severe condition primarily triggered by viruses. Anti-RNA polymerase III autoantibodies (RNApol3) which are typically found in patients with systemic sclerosis, have been reported influenza-related FM. Our objective to provide additional insight into RNApol3-associated Methods We retrospectively included all admitted our institution between January 2013 and June 2023 acute positive serum RNApol3. compared their characteristics, etiologies,...
Abstract Background During the first COVID-19 pandemic wave, COVID-19-associated pulmonary aspergillosis (CAPA) has been reported in up to 11–28% of critically ill patients and associated with increased mortality. As new SARS-CoV-2 variants emerged, characteristics have evolved, particularly era Omicron. The purpose this study is investigate CAPA variants. Methods This a prospective multicenter observational cohort conducted France 36 participating intensive care units (ICU), between...
Consumer products intended for distribution to the public need be tested their capacity cause irritation or injury as a result of accidental exposure eye. Results from three animal eye test methods, used assess potential, were compared documented human experience selected categories household consumer products. All methods produced more severe responses than reported accidents with same The low-volume rabbit gave closer correlation data did any other tests. support conclusion that permits...
ABSTRACT A notable increase in severe cases of COVID-19, with significant hospitalizations due to the emergence and spread JN.1 was observed worldwide late 2023 early 2024. During study period (November 2022-January 2024), 56 JN.1- 126 XBB-infected patients were prospectively enrolled 40 French intensive care units. JN.1-infected more likely be obese (35.7% vs 20.8%; p=0.033) less frequently immunosuppressed than others (20.4% 41.4%; p=0.010). required invasive mechanical ventilation support...
A notable increase in severe cases of COVID-19, with significant hospitalizations due to the emergence and spread JN.1 was observed worldwide late 2023 early 2024. However, no clinical data are available regarding critically-ill COVID-19 infected patients. The current study is a substudy SEVARVIR prospective multicenter observational cohort study. Patients admitted any 40 participating ICUs between November 17, 2022, January 22, 2024, were eligible for inclusion (NCT05162508) if they met...
Abstract Background Antimicrobial stewardship (AMS) for ventilator-associated pneumonia (VAP) in carriers of extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) presents significant challenges. The abundance ESBL-E rectal carriage has emerged as a potentially valuable tool predicting ESBL-E-related VAP. Methods This single-center, retrospective study was conducted between October 2019 and April 2023 the medical ICU university hospital. relative (RAC) calculated ratio counts to...
Abstract Background Antimicrobial stewardship (AMS) for ventilator-associated pneumonia (VAP) or ventilated hospital-acquired (vHAP) in extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) carriers is challenging. BioFire® FilmArray® Pneumonia plus Panel (mPCR) can detect bacteria and antibiotic resistance genes, including bla CTX-M , the most common ESBL-encoding gene. Methods This monocentric, prospective study was conducted on a group of ESBL-E from March 2020 to August 2022....
Abstract RSV can cause severe infections in the elderly. Nirsevimab is a novel prophylactic monoclonal antibody, widely used infants France during 2023/2024 season. It may select for resistant variants that, if transmitted community, could compromise vaccine efficacy In this study, we analyzed full-length genomes (68% RSV-A, 32% RSV-B) from 125 patients >60y Genetic diversity of RSV-F was low, with no resistance-associated substitutions (RASs) detected. While RASs were identified,...
Abstract Background Monoclonal gammopathy-associated capillary leak syndrome (MG-CLS) is a rare condition characterized by recurrent episodes of hypovolemic shock caused sudden increase in permeability. The COVID-19 pandemic has been associated with rise MG-CLS and increased mortality. We aimed to explore the association between SARS-CoV-2 infection. conducted multicenter retrospective observational study involving patients who were admitted intensive care unit (ICU). primary endpoint was...
Abstract Background Despite current broad natural and vaccine-induced protection, a substantial number of patients infected with emerging SARS-CoV-2 variants (e.g., BF.7 BQ.1.1) still experience severe COVID-19. Real-life studies investigating the impact these on clinical outcomes cases are currently not available. We performed prospective multicenter observational cohort study. Adult acute respiratory failure admitted between December 7, 2021 15, 2022, in one 20 participating intensive care...
Abstract Background Fulminant myocarditis is a rare and severe disease whose definite etiological diagnoses rely on pathological examination. Albeit, myocardial biopsy can be associated with significant morbidity mortality, its therapeutic consequences are unclear. We conducted study to determine the diagnostic yield, safety of in patients fulminant clinically suspected unweanable from mechanical circulatory support (MCS). Methods Monocenter, retrospective, observational cohort 26-bed French...
Abstract Background Systemic rheumatic diseases (SRDs) are a group of inflammatory disorders that can require intensive care unit (ICU) admission because multiorgan involvement with end-organ failure(s). Critically ill SRD patients requiring extracorporeal membrane oxygenation (ECMO) were studied to gain insight into their characteristics and outcomes. Methods This French monocenter, retrospective study included all venovenous (VV)- or venoarterial (VA)-ECMO admitted 26-bed ECMO-dedicated...
Eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg−Strauss syndrome, is a small- to medium-sized systemic necrotizing vasculitis characterized by eosinophil-rich tissue infiltrates and granulomatous lesions. belongs the larger subgroup of anti-neutrophil cytoplasm antibodies (ANCA)−associated vasculitides. However, EGPA distinct biological clinical presentation when compared (GPA) microscopic (MPA).
Rationale: Up to 15% of critically ill patients receive platelets in intensive care units (ICU) (1).Both preventive and therapeutic platelet transfusions (PT) are not fully supported by high levels evidence the benefits transfusion remain subject debates some settings.This study aims describe efficacy PT ICU, its impact on patients' outcomes.Patients methods/Materials methods: From June 2018 November 2019, we conducted a prospective multicenter observational recruiting that received at least...