A5079213435- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Opioid Use Disorder Treatment
- HIV Research and Treatment
- Pharmacological Effects and Toxicity Studies
- Noise Effects and Management
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Animal testing and alternatives
- Acoustic Wave Phenomena Research
- Substance Abuse Treatment and Outcomes
- Vehicle Noise and Vibration Control
- Liver Disease Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Prenatal Substance Exposure Effects
- Environmental Toxicology and Ecotoxicology
- Alcohol Consumption and Health Effects
- Pain Management and Opioid Use
- HIV-related health complications and treatments
- Forensic Toxicology and Drug Analysis
- Hepatitis B Virus Studies
- Epilepsy research and treatment
- Sex work and related issues
- Pesticide Exposure and Toxicity
- Pneumocystis jirovecii pneumonia detection and treatment
MetroHealth Medical Center
2024
Case Western Reserve University
2024
University of Tennessee Health Science Center
2023
Boston University
2020-2022
Boston Medical Center
2022
Cornell Scott-Hill Health Center
2015-2019
Cornell University
2015-2019
Yale University
2009-2018
Pangaea Global AIDS Foundation
2013-2016
Madigan Army Medical Center
2015
Having opioid dependence and HIV infection are associated with poor HIV-related treatment outcomes.
An Up-and-Down Procedure for Acute Toxicity Testing. BRUCE, R. D. (1985). Fundam. Appl. Toxicol. 5, 151–157. up-and down method acute toxicity (LD50) testing has been developed and statistically evaluated. Compared with the “classical” procedure, this permits a major reduction in number of animals used. In up-and-down are dosed one at time. If an animal survives, dose next is increased; if it dies, decreased. A survey 48 tests rats showed that great majority ultimately died did so within 1...
Directly administered antiretroviral therapy (DAART) is one approach to improve treatment adherence among human immunodeficiency virus (HIV)-infected drug users.In this randomized, controlled trial (ClinicalTrials.gov identifier, NCT00367172), the biological outcomes of a 6-month community intervention DAART were compared with those self-administered HIV-infected users. Patients randomized receive received supervised 5 days per week from workers in mobile health care van. The primary...
Prisoners bear much of the burden hepatitis C epidemic in United States. Yet little is known about scope and cost treating state prisons-particularly since release direct-acting antiviral medications. In forty-one states whose departments corrections reported data, 106,266 inmates (10 percent their prisoners) were to have on or January 1, 2015. Only 949 (0.89 percent) those being treated. Prices for a twelve-week course antivirals such as sofosbuvir combination drug ledipasvir/sofosbuvir...
Abstract Chronic aquatic toxicity test results are commonly analyzed with statistical hypothesis tests to generate summary statistics known as the no‐observed‐effect concentration (NOEC) and first‐observed‐effect (FOEC). These procedures address differences among treatments but suffer several critical limitations. Use of concentration‐response estimate minimal effect concentrations (i.e., EC values) from quantal continuous data has advantages over a hypothesis‐testing approach for generating...
Directly administered antiretroviral therapy (DAART) is one approach to improving adherence among human immunodeficiency virus (HIV)—infected drug users. We evaluated the essential features of a community-based DAART intervention in randomized, controlled trial versus self-administered therapy. Of initial 72 subjects, 78% were racial minorities, and 32% women. Social medical comorbidities subjects included homelessness (35% subjects), lack interpersonal support (86%), major depression (57%),...
Silver-Russell syndrome (SRS, OMIM 180860) features fetal and postnatal growth restriction variable dysmorphisms. Genetic epigenetic aberrations on chromosomes 7 11 are commonly found in SRS. However, a large fraction of SRS cases remain with unknown genetic aetiology.22 patients diagnosis (10 H19 hypomethylation 12 molecular aetiology) their parents were studied the Affymetrix 250K Sty microarray. Several analytical approaches used to identify genomic such as copy number changes (CNCs),...
Introduction Current estimates suggest an HIV prevalence of 42% among people who inject drugs (PWIDs) in Dar es Salaam, while is estimated to be 8.8% the general population city. To address epidemic this population, government Tanzania began establishing prevention, treatment and care services including outreach medication assisted (MAT) for PWIDs 2010. We assessed gender inequities utilization MAT evaluated differences risk behaviors between female male PWIDs. Materials Methods Routine data...
Background. The effectiveness of interferon-free direct-acting antivirals (DAA) in treating chronic hepatitis C virus (HCV) is limited by low screening and treatment rates, particularly among people who inject drugs (PWIDs).
Background: Diversion of buprenorphine (BPN) has been described in settings where it is legally prescribed and resulted increasing concern. To address this concern, co-formulation buprenorphine/naloxone (BPN/NLX) replaced alone Malaysia December 2006. Methods: assess the significance BPN/NLX introduction, 41 injectors Kuala Lumpur, were recruited using a modified snowball recruitment technique. Results: In January 2007, all subjects had previously injected BPN alone. During transition from...
More than one-third of people in the United States with hepatic C virus (HCV) infection pass through correctional system annually. Data are lacking on outcomes treatment pegylated interferon plus ribavirin (PEG-RBV) settings.