Joseph K. Lim
A5008472753- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- HIV/AIDS drug development and treatment
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Drug-Induced Hepatotoxicity and Protection
- HIV-related health complications and treatments
- Alcohol Consumption and Health Effects
- Colorectal Cancer Screening and Detection
- COVID-19 Clinical Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Diet, Metabolism, and Disease
- SARS-CoV-2 and COVID-19 Research
- Organ Transplantation Techniques and Outcomes
- Diabetes Treatment and Management
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- Primary Care and Health Outcomes
- HIV/AIDS Research and Interventions
- Renal Transplantation Outcomes and Treatments
Yale University
2016-2025
Yale Cancer Center
2016-2025
New York Hospital Queens
2025
Columbia University
2025
NewYork–Presbyterian Hospital
2025
VA Connecticut Healthcare System
2013-2024
United States Department of Veterans Affairs
2024
Kaleida Health
2024
Children's Hospital Colorado
2024
University of Colorado Denver
2024
There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more severe symptoms and higher mortality among men than women1–5. However, whether immune responses against acute respiratory syndrome (SARS-CoV-2) differ between sexes, such differences correlate with the sex difference in course of COVID-19, currently unknown. Here we examined viral loads, SARS-CoV-2-specific antibody titres, plasma cytokines blood-cell phenotyping patients moderate COVID-19 who had not...
Clinicians are required to assess abnormal liver chemistries on a daily basis. The most common ordered serum alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase and bilirubin. These tests should be termed or tests. Hepatocellular injury is defined as disproportionate elevation of AST ALT levels compared with levels. Cholestatic level majority bilirubin circulates unconjugated an elevated conjugated implies hepatocellular disease cholestasis. Multiple studies have...
Acute kidney injury (AKI) is a common and devastating complication in patients with cirrhosis. However, the definitions of AKI employed studies involving cirrhosis have not been standardized, lack sensitivity, are often limited to narrow clinical settings. We conducted multicenter, prospective observational cohort study AKI, drawn from multiple hospital wards, utilizing modern acute network (AKIN) definition assessed association between severity progression in-hospital mortality. Of 192 who...
Renal clearance is the major elimination pathway for sofosbuvir (SOF). We assessed safety and efficacy of SOF-containing regimens in patients with varying baseline estimated glomerular filtration rate (eGFR).HCV-TARGET database a multicentre, longitudinal 'real-world' treatment cohort.A total 1789 [genotypes 1 (72%), 2 (17%) 3 (9%), 4-6 (2%)] had eGFR determination: 73 eGFR≤45 (18 eGFR≤30, 5 on dialysis) were compared to 1716 eGFR>45 ml/min/1.73 m(2) . Patients vs. >45 differed being female...
Background and Aims The coronavirus‐19 disease (COVID‐19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 virus, is associated with significant morbidity mortality attributable to pneumonia, distress syndrome, multiorgan failure. Liver injury has been reported as a nonpulmonary manifestation of COVID‐19, but characterization liver test abnormalities their association clinical outcomes incomplete. Approach Results We conducted retrospective cohort study 1,827 patients...
Background: The incidence and determinants of hepatic decompensation have been incompletely examined among patients co-infected with HIV hepatitis C virus (HCV) in the antiretroviral therapy (ART) era, few studies compared outcome rates those chronic HCV alone. Objective: To compare between antiretroviral-treated HCV-monoinfected to evaluate factors associated receiving ART. Design: Retrospective cohort study. Setting: Veterans Health Administration. Patients: 4280 who initiated ART 6079...