Chantal B. F. Vogels
A5020712494- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Insect symbiosis and bacterial influences
- Long-Term Effects of COVID-19
- Advanced biosensing and bioanalysis techniques
- Malaria Research and Control
- Vector-borne infectious diseases
- COVID-19 epidemiological studies
- Poxvirus research and outbreaks
- Biosensors and Analytical Detection
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Animal Virus Infections Studies
- COVID-19 diagnosis using AI
- Vector-Borne Animal Diseases
- Zoonotic diseases and public health
- Dental Research and COVID-19
- COVID-19 Impact on Reproduction
- Bacillus and Francisella bacterial research
- Plant Virus Research Studies
- Viral Infections and Outbreaks Research
- Bacteriophages and microbial interactions
Yale University
2018-2025
Yale New Haven Health System
2021-2023
Center for Genomic Science
2022
ETH Zurich
2022
Howard Hughes Medical Institute
2021
Connecticut Agricultural Experiment Station
2020-2021
Wageningen University & Research
2014-2021
Serimmune (United States)
2021
Institute of Entomology
2017
Smithsonian Tropical Research Institute
2015
There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more severe symptoms and higher mortality among men than women1–5. However, whether immune responses against acute respiratory syndrome (SARS-CoV-2) differ between sexes, such differences correlate with the sex difference in course of COVID-19, currently unknown. Here we examined viral loads, SARS-CoV-2-specific antibody titres, plasma cytokines blood-cell phenotyping patients moderate COVID-19 who had not...
BACKGROUND. The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case second trimester with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption.
The recent emergence of the SARS-CoV-2 Omicron variant is raising concerns because its increased transmissibility and numerous spike mutations, which have potential to evade neutralizing antibodies elicited by COVID-19 vaccines. Here we evaluated effects a heterologous BNT162b2 mRNA vaccine booster on humoral immunity participants who had received two-dose regimen CoronaVac, an inactivated used globally. We found that CoronaVac prime vaccination two doses followed induces elevated...
The emergence of SARS-CoV-2 variants with mutations in major neutralizing antibody-binding sites can affect humoral immunity induced by infection or vaccination1-6. Here we analysed the development anti-SARS-CoV-2 antibody and T cell responses individuals who were previously infected (recovered) uninfected (naive) received mRNA vaccines to SARS-CoV-2. While sustained higher titres than post-vaccination, latter reached comparable levels neutralization ancestral strain after second vaccine...
With the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants that may increase transmissibility and/or cause escape from immune responses, there is an urgent need for targeted surveillance circulating lineages. It was found B.1.1.7 (also 501Y.V1) variant, first detected in United Kingdom, could be serendipitously by Thermo Fisher TaqPath COVID-19 PCR assay because a key deletion these viruses, spike Δ69-70, would "spike gene target failure" (SGTF) result....
Epidemiological synergy between outbreaks of viruses transmitted by Aedes aegypti mosquitoes, such as chikungunya, dengue, and Zika viruses, has resulted in coinfection humans with multiple viruses. Despite the potential impact on public health, we know only little about occurrence consequences coinfections. Here, review clinical disease humans, discuss possibility for co-transmission from mosquito to human, describe a role modeling transmission dynamics at various levels co-transmission....
BackgroundPregnant women are at increased risk for severe outcomes from coronavirus disease 2019 (COVID-19), but the pathophysiology underlying this morbidity and its potential effect on developing fetus is not well understood.MethodsWe assessed placental histology, ACE2 expression, viral immune dynamics term placenta in pregnant with without respiratory acute syndrome 2 (SARS-CoV-2) infection.FindingsThe majority (13 of 15) placentas analyzed had no detectable RNA. was detected by...
SARS-CoV-2 infections are characterized by viral proliferation and clearance phases can be followed low-level persistent RNA shedding. The dynamics of concentration, particularly in the early stages infection, inform clinical measures interventions such as test-based screening. We used prospective longitudinal quantitative reverse transcription PCR testing to measure trajectories for 68 individuals during resumption 2019–2020 National Basketball Association season. For 46 with acute...
Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological symptoms, but the biological underpinnings of these phenomena are unknown. Through single-cell RNA sequencing (scRNA-seq) and cytokine analyses cerebrospinal fluid (CSF) blood from individuals COVID-19 we find compartmentalized, CNS-specific T cell activation B responses. All affected had CSF anti-severe acute respiratory syndrome 2 (SARS-CoV-2) antibodies whose target epitopes diverged serum antibodies. In...
The SARS-CoV-2 Delta variant rose to dominance in mid-2021, likely propelled by an estimated 40%–80% increased transmissibility over Alpha. To investigate if this ostensible difference is uniform across populations, we partner with public health programs from all six states New England the United States. We compare logistic growth rates during each variant's respective emergence period, finding that emerged 1.37–2.63 times faster than Alpha (range states). compute variant-specific effective...
Abstract Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe COVID-19. However, signatures associated with immunopathology poorly understood. Here we use multi-omics single-cell analysis to probe dynamic hospitalized patients stable or progressive course of COVID-19, explore V(D)J repertoires, and assess cellular effects tocilizumab. Coordinated profiling gene expression cell lineage protein markers shows that S100A hi /HLA-DR lo classical monocytes...
While several clinical and immunological parameters correlate with disease severity mortality in SARS-CoV-2 infection, work remains identifying unifying correlates of coronavirus 2019 (COVID-19) that can be used to guide practice. Here, we examine saliva nasopharyngeal (NP) viral load over time them patient demographics, cellular immune profiling. We found was significantly higher those COVID-19 risk factors; it correlated increasing levels showed a superior ability as predictor (AUC=0.90)....
The chronic infection hypothesis for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant emergence is increasingly gaining credence following the appearance of Omicron. Here, we investigate intrahost evolution and genetic diversity lineage B.1.517 during a SARS-CoV-2 lasting 471 days (and still ongoing) with consistently recovered infectious virus high viral genome copies. During infection, find an accelerated evolutionary rate translating to 35 nucleotide...
Abstract West Nile virus (WNV) is an emerging mosquito-borne pathogen in Europe where it represents a new public health threat. While climate change has been cited as potential driver of its spatial expansion on the continent, formal evaluation this causal relationship lacking. Here, we investigate extent to which WNV can be attributed while accounting for other direct human influences such land-use and population changes. To end, trained ecological niche models predict risk local...
Abstract Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands Caribbean have experienced more frequent outbreaks, all four dengue virus (DENV) serotypes been reported region, leading hyperendemicity increased rates of severe disease. However, there significant variability regarding surveillance reporting between islands, making it difficult obtain an accurate understanding epidemiological patterns Caribbean. To...