A5024931742- Cardiac Structural Anomalies and Repair
- HIV/AIDS Research and Interventions
- Cardiac Valve Diseases and Treatments
- Adolescent Sexual and Reproductive Health
- Cardiovascular Function and Risk Factors
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Injury Epidemiology and Prevention
- Viral Infections and Immunology Research
- Occupational Health and Performance
- Heart Failure Treatment and Management
- Global Maternal and Child Health
- Vaccine Coverage and Hesitancy
- Cardiac Imaging and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood Pressure and Hypertension Studies
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Atrial Fibrillation Management and Outcomes
- SARS-CoV-2 detection and testing
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Child Nutrition and Feeding Issues
Sylvester Comprehensive Cancer Center
2020-2021
University of Miami
2020-2021
National Institutes of Health
2020-2021
Foundation for Human Potential
2020-2021
Florida State University
2021
Emory University
2021
Ethics and Public Policy Center
2021
Sulzer (United Kingdom)
2020
Center for Disease Control
2019
University of Novi Sad
2015
The recent emergence of the SARS-CoV-2 Omicron variant is raising concerns because its increased transmissibility and numerous spike mutations, which have potential to evade neutralizing antibodies elicited by COVID-19 vaccines. Here we evaluated effects a heterologous BNT162b2 mRNA vaccine booster on humoral immunity participants who had received two-dose regimen CoronaVac, an inactivated used globally. We found that CoronaVac prime vaccination two doses followed induces elevated...
Ularitide is a synthetic form of urodilatin, natriuretic peptide produced in the kidney with vasodilating, natriuretic, and diuretic effects, that offers promise for management decompensated heart failure (DHF). We assessed efficacy safety ularitide treating patients DHF.In this Phase II randomized, double-blind, placebo-controlled trial, 221 DHF received either placebo (n=53) or at 7.5 ng/kg/min (n=60), 15 (n=53), 30 (n=55) as 24-h continuous infusion. At 6 h, demonstrated significant...
A large proportion of the 2.5 million new adult HIV infections that occurred worldwide in 2007 were stable couples. Feasible and acceptable strategies to improve prevention a conjugal context are scarce. In preparatory phase ANRS 12127 Prenahtest multi-site trial, we assessed acceptability couple-oriented post-test counseling (COC) men's involvement within prenatal care services, among pregnant women, male partners health workers Cameroon, Dominican Republic, Georgia India. Quantitative...
Abstract The recent emergence of the SARS-CoV-2 Omicron variant is raising concerns because its increased transmissibility and by numerous spike mutations with potential to evade neutralizing antibodies elicited COVID-19 vaccines. Dominican Republic was among first countries in recommending administration a third dose vaccine address waning immunity reduced effectiveness against variants. Here, we evaluated effects heterologous BNT162b2 mRNA booster on humoral participants that had received...
Objective: Couple-oriented posttest HIV counselling (COC) provides pregnant women with tools and strategies to invite her partner testing. We conducted a randomized trial of the efficacy COC on testing in low/medium prevalence settings (Cameroon, Dominican Republic, Georgia, India). Methods: Pregnant were receive standard or followed until 6 months postpartum. Partner events notified by site laboratories, self-reported both combined. Impact was measured intention-to-treat analysis....
The emergence of the SARS-CoV-2 Omicron sublineages resulted in increased transmission rates and reduced protection from vaccines. To counteract these effects, multiple booster strategies were used different countries, although data comparing their efficiency improving protective immunity remain sparse, especially among vulnerable populations, including older adults. inactivated CoronaVac vaccine was most widely distributed worldwide essential early control SARS-CoV-2–related...
OBJECTIVE: To determine whether giving interferon-alpha or thymomodulin in addition to conventional treatment improves cardiac function patients with idiopathic myocarditis and dilated cardiomyopathy. DESIGN: Single-centre, randomised, open label, parallel group comparison of plus interferon-alpha, thymomodulin, alone. PATIENTS: 38 aged 19-54 years (23 men) biopsy-proven 12 were treated alone, 13 treatment, treatment. SETTING: Tertiary referral centre. MAIN OUTCOME MEASURES: Clinical...
The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic public interest. We investigated 2 the most widely propagated claims to determine (1) whether COVID-19 mice during early is associated with an increased incidence birth defects or growth abnormalities; (2) mRNA-vaccinated human volunteers exhibit elevated levels antibodies placental protein syncytin-1. Using mouse model, we found that intramuscular at gestational age E7.5...
No study has directly compared different histomorphometric methods of quantification myocardial fibrosis. Therefore we the results semiquantitative, point-counting and computer-based in assessement fibrosis a consecutive series endomyocardial biopsy samples from patients with heart muscle disease.Histological (at least three per patient) were obtained by 11 focal myocarditis 24 ambulatory idiopathic dilated cardiomyopathy, or during surgery 10 who underwent partial left ventriculectomy....
Objective: Characterize objective measurements of carcinogenic exposure using passive sampling silicone-based wristbands among Dominican firefighters. Methods: Firefighters from a metropolitan fire service in the Republic were asked to wear wristband during one typical 24-hour shift. A pre- and post-shift survey collected work shift characteristics. Wristbands processed for type quantity polycyclic aromatic hydrocarbons (PAHs), family known compounds. Results: Fifteen firefighters wore...
It is becoming increasingly apparent that idiopathic dilated cardiomyopathy (IDC) probably results from an acute viral myocarditis. One reasonable hypothesis persistent infection causes myocardial destruction leading to left ventricular dilatation and heart failure. The aim of this study was evaluate the efficacy interferon-a (IFN) thymomodulin in treatment myocarditis IDC. Clinical, immunological, haemodynamic histological evaluation performed 40 patients before inclusion study. Patients...
Abstract Background A continuing nationwide vaccination campaign began in the Dominican Republic on February 16, 2021 to prevent severe consequences of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Estimates vaccine effectiveness under real-world conditions are needed support policy decision making and inform further selection. Methods We conducted a test-negative case-control study assess disease 2019 (COVID-19) program using an inactivated (CoronaVac) preventing...
Couples HIV counseling and testing is essential for combination prevention, but its uptake remains very low. We aimed to evaluate factors associated with couples in India, Georgia the Dominican Republic, as part of ANRS 12127 Prenahtest intervention trial. Pregnant women ≥15 years, attending their first antenatal care (ANC) session between March September 2009, self-reporting a stable partner, having received couple-oriented post-test (trial intervention) were included. Individuals couple...
RESUMEN: Pese a su presencia temprana en las sociedades humanas, el estudio del estigma desde ciencias sociales se inicia mediados siglo XX, constituyendo la definición de Erving Goffman como un atributo profundamente desacreditador dentro una interacción social particular, primeras aproximaciones al sistemático y formal este concepto. A diferencia muchos autores contemporaneos, identifica oportunamente los rasgos propios que permiten clara delimitación con respecto otros fenómenos...
While partial left ventriculectomy (PLV) may improve functional status, the duration and determinants of this improvement are poorly known. This study sought to assess relationship between ventricular (LV) shape function status in late survivors after PLV for non-ischemic dilated cardiomyopathy (DCM).We assessed relations LV 17 consecutive patients who survived >12 months DCM. Invasive diagnostic studies were performed before, early after, at mid-term PLV. According their follow-up, divided...
<h3>OBJECTIVE</h3> To assess the effect of partial left ventriculectomy (PLV) on estimate ventricular end systolic elastance (Ees), arterial elastance, and ventriculoarterial coupling. <h3>PATIENTS</h3> 11 patients with idiopathic dilated cardiomyopathy before two weeks after PLV, controls. <h3>INTERVENTIONS</h3> Single plane angiography simultaneous measurements femoral artery pressure was performed during right heart pacing load reduction. <h3>RESULTS</h3> PLV increased mean (SD) Ees from...
PURPOSE Firefighters around the world are exposed to physical hazards and toxic chemical agents during fire incident response. Occupational epidemiologic studies of firefighter workforce have documented an excess cancer risk for brain, digestive, genitourinary, lymphohematopoietic organs compared with general population. Despite elevated risk, little is known about what specific types carcinogenic chemicals first responders encounter a typical work shift, particularly in low-resources...