A5101892222- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Eicosanoids and Hypertension Pharmacology
- HER2/EGFR in Cancer Research
- Nuclear Structure and Function
- Cell death mechanisms and regulation
- Inflammatory mediators and NSAID effects
- Animal Virus Infections Studies
- Parvovirus B19 Infection Studies
- Birth, Development, and Health
- RNA Research and Splicing
- Gestational Diabetes Research and Management
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
University of Massachusetts Amherst
2025
Cornell University
2024
Asan Medical Center
2023
University of Ulsan
2023
Ulsan College
2023
Yale University
2021-2022
BackgroundPregnant women are at increased risk for severe outcomes from coronavirus disease 2019 (COVID-19), but the pathophysiology underlying this morbidity and its potential effect on developing fetus is not well understood.MethodsWe assessed placental histology, ACE2 expression, viral immune dynamics term placenta in pregnant with without respiratory acute syndrome 2 (SARS-CoV-2) infection.FindingsThe majority (13 of 15) placentas analyzed had no detectable RNA. was detected by...
The nucleus houses genetic information and functions separate from the rest of cell. Loss nuclear shape results in ruptures. Nuclear blebs are deformations identified by decreased DNA density, while lamin B levels vary drastically. To determine if due to rupture, we used immunofluorescence measure emerin, a envelope protein that enriches sites rupture. We observed cell types exhibit also show an enrichment emerin blebs. Oppositely, other types, display maintained B1 showed no enrichment. how...
Abstract Pregnant women appear to be at increased risk for severe outcomes associated with COVID-19, but the pathophysiology underlying this morbidity and its potential impact on developing fetus is not well understood. In study of pregnant without we assessed viral immune dynamics placenta during maternal SARS-CoV-2 infection. Amongst uninfected women, ACE2 was detected by immunohistochemistry in syncytiotrophoblast cells normal early pregnancy rarely seen healthy placentas full term. Term...
The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic public interest. We investigated 2 the most widely propagated claims to determine (1) whether COVID-19 mice during early is associated with an increased incidence birth defects or growth abnormalities; (2) mRNA-vaccinated human volunteers exhibit elevated levels antibodies placental protein syncytin-1. Using mouse model, we found that intramuscular at gestational age E7.5...
Abstract The impact of coronavirus disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic public interest. We investigated two the most widely propagated claims to determine 1) whether COVID-19 mice during early is associated with an increased incidence birth defects or growth abnormalities, 2) mRNA-vaccinated human volunteers exhibit elevated levels antibodies placental protein syncytin-1. Using mouse model, we found that intramuscular at gestational...