Guillaume Lefèvre
A5028044238- Eosinophilic Disorders and Syndromes
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Acute Myocardial Infarction Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Pregnancy and preeclampsia studies
- Urticaria and Related Conditions
- Mast cells and histamine
- COVID-19 Clinical Research Studies
- Cardiac Imaging and Diagnostics
- Asthma and respiratory diseases
- Inflammatory Myopathies and Dermatomyositis
- Immune Cell Function and Interaction
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Heart Failure Treatment and Management
- Drug-Induced Adverse Reactions
- Birth, Development, and Health
- Pneumocystis jirovecii pneumonia detection and treatment
- IL-33, ST2, and ILC Pathways
- Reproductive System and Pregnancy
- Venous Thromboembolism Diagnosis and Management
- Systemic Lupus Erythematosus Research
- Coronary Interventions and Diagnostics
Sorbonne Université
2015-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Université de Lille
2016-2025
Inserm
2016-2025
Lille Inflammation Research International Center
2016-2025
Centre Hospitalier Universitaire de Lille
2016-2025
Center for Infection and Immunity of Lille
2015-2025
Institute for Translational Research in Inflammation
2020-2025
Université Lille Nord de France
2011-2025
Hôpital Tenon
2015-2025
Patients with primary biliary cholangitis who have an inadequate response to therapy ursodeoxycholic acid are at high risk for disease progression. Fibrates, which agonists of peroxisome proliferator-activated receptors, in combination acid, shown potential benefit patients this condition.In 24-month, double-blind, placebo-controlled, phase 3 trial, we randomly assigned 100 had according the Paris 2 criteria receive bezafibrate a daily dose 400 mg (50 patients), or placebo addition continued...
To investigate disturbances in the coronary circulation and myocardial metabolism during septic shock, we examined sinus blood flow substrate extraction 40 patients with shock 13 control patients. Patients artery disease were excluded from this study. The global hemodynamic pattern of was characterized by a lower stroke volume, despite an elevated cardiac index. Coronary high (187 +/- 47 vs 130 21 ml/min group, p less than .001) due to marked vasodilation, especially subgroup nonsurvivors....
Abstract International recommendations highlight the superior value of cardiac troponins (cTns) for early diagnosis myocardial infarction along with analytical requirements improved precision and detectability. In this multicenter study, we investigated performance a new high sensitive troponin I (hs-cTnI) assay its 99th percentile upper reference limit (URL). Laboratories from nine European countries evaluated ARCHITECT Total imprecision 3.3%–8.9%, 2.0%–3.5% 1.5%–5.2% was determined low,...
The CD3-CD4+ aberrant T-cell phenotype is the most described in lymphoid variant of hypereosinophilic syndrome (L-HES), a rare form HES. Only few cases have been reported, and data for these patients are scarce. To describe characteristics outcome L-HES patients, we conducted national multicentric retrospective study French Eosinophil Network. All who met recent criteria hypereosinophilia (HE) or HES had persistent subset on blood phenotyping were included. Clinical laboratory...
Objective: Whether endotheliopathy only mirrors coronavirus disease 2019 (COVID-19) severity or plays an intrinsic role in microvascular thrombosis and organ failure remains unanswered. We assessed whether markers of endothelial damage immune dysregulation were associated with failure, thrombus formation, death. Approach Results: Markers (VWF:Ag [von Willebrand factor antigen], PAI-1 [plasminogen activator inhibitor-1], syndecan-1, TFPI [tissue pathway inhibitor], soluble thrombomodulin),...
Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim this study was to focus on the specific T-cell response. We quantified S1-specific IgG, neutralizing titers, total IFNγ-secreting T cells by ELISpot, functionality CD4 + - CD8 -specific flow...
Eosinophilic-related clinical manifestations are protean and the underlying conditions underpinning eosinophilia highly diverse. The etiological workup of unexplained eosinophilia/hypereosinophilia can be challenging, lead sometimes to extensive, inappropriate, costly and/or invasive investigations. To date, guidelines for management mainly issued by hematologists, thus mostly cover scope clonal hypereosinophilic syndromes (HES). Here, thanks an extensive literature review, joint work a...
Hypereosinophilic syndromes (HES) are a heterogenous group of eosinophilic disorders. To date, only retrospective studies limited sample-size and/or follow-up duration available. The COHESion study is national prospective multicenter multidisciplinary cohort recruiting both adults or children with the spectrum disorders (including reactive HE/HES [HE/HES-R], idiopathic HES [HES-I], lymphocytic [HES-L], neoplastic [HE/HES-N], HE unknown significance [HE-US], as well IgG4-related disease...
Midwall myocardial fibrosis on cardiovascular magnetic resonance (CMR) is a marker of early ventricular decompensation and adverse outcomes in aortic stenosis (AS). We aimed to develop validate novel clinical score using variables associated with midwall fibrosis.
W I T H the discovery of linkage and crossing over, geneticists acquired a technique for estimating physical distances between genes on chromosome.From first, however, accuracy maps has been viewed with reservation.Too many extraneous factors, including temperature (PLOUGH 1917) maternal age (BRIDGES 1927), were shown to modify values.Furthermore, both crossover suppressors enhancers identified.Nevertheless, until independent procedures developed, recombination values, necessity, remained...
Eosinophils are multifunctional leukocytes that involved in innate and adaptive immune responses through the expression of various receptors mediators. Previously, we showed human eosinophils T cells shared cytotoxic activities against tumor γ-δ TCR cell-cell contact. In this study, investigated molecules eosinophil-tumor cell interactions. Given role IL-18 adhesion protecting colon cancer, evaluated its eosinophil-mediated cytotoxicity Colo-205, a carcinoma line. We found exerted dose-...