A5026054699- Vasculitis and related conditions
- Sepsis Diagnosis and Treatment
- Statistical Methods and Bayesian Inference
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Intensive Care Unit Cognitive Disorders
- Advanced Breast Cancer Therapies
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Hepatitis C virus research
- Melanoma and MAPK Pathways
- Statistical Methods in Clinical Trials
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Advanced Causal Inference Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Estrogen and related hormone effects
- Retinal and Optic Conditions
- Statistical Methods and Inference
- Family and Patient Care in Intensive Care Units
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Esophageal and GI Pathology
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
Hôpital Saint-Louis
2016-2025
Inserm
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris Cité
2016-2025
Sorbonne Paris Cité
2015-2024
Centre de Recherche Épidémiologie et Statistique
2015-2024
Saint Louis University Hospital
2009-2024
Institut de recherche Saint-Louis
2024
Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique
2024
Rockefeller University
2023-2024
<h3>Importance</h3> Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19). <h3>Objective</h3> To determine whether tocilizumab (TCZ) improves outcomes patients hospitalized moderate-to-severe COVID-19 pneumonia. <h3>Design, Setting, Particpants</h3> This cohort-embedded, investigator-initiated, multicenter, open-label, bayesian randomized clinical trial investigating moderate or severe requiring at least 3 L/min...
Objectives To describe neurodevelopmental outcomes at 2 years corrected age for children born alive 22-26, 27-31, and 32-34 weeks' gestation in 2011, to evaluate changes since 1997.Design Population based cohort studies, EPIPAGE EPIPAGE-2.Setting France.Participants 5567 neonates 2011 22-34 completed gestation, with 4199 survivors included follow-up. Comparison of reported 3334 (1997) 2418 (2011) the nine regions participating both studies.Main outcome measures Survival; cerebral palsy (2000...
for the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GRRR-OH) IMPORTANCE Noninvasive ventilation has been recommended to decrease mortality among immunocompromised patients with hypoxemic acute respiratory failure.However, its effectiveness this indication remains unclear.OBJECTIVE To determine whether early noninvasive improved survival in nonhypercapnic failure.
Patients with COVID-19 pneumonia have an excess of inflammation and increased concentrations cytokines including interleukin-1 (IL-1). We aimed to determine whether anakinra, a recombinant human IL-1 receptor antagonist, could improve outcomes in patients hospital mild-to-moderate pneumonia.In this multicentre, open-label, Bayesian randomised clinical trial (CORIMUNO-ANA-1), nested within the CORIMUNO-19 cohort, we recruited from 16 University hospitals France pneumonia, severe acute...
To report the long-term mortality in patients with Behçet's disease (BD).A cohort of 817 fulfilling international criteria for BD from a single center France were analyzed causes death, standardized ratio (SMR), and factors associated mortality.Among BD, 41 (5%) died after median followup 7.7 years, whom 95.1% male. The mean ± SD age at death was 34.8 11.9 years. Main included major vessel (mainly, arterial aneurysm Budd-Chiari syndrome) (43.9%), cancer malignant hemopathy (14.6%), central...
Background— With recent advances in endovascular treatment, percutaneous endoluminal angioplasty has become particularly attractive for arterial lesions of Takayasu arteritis. However, data came from case reports or small series, and the long-term outcome not been reported. The incidence potential vascular complications after surgery treatment is still to be determined. Methods Results— This retrospective multicenter study analyzed results outcomes 79 consecutive patients with arteritis...
Rationale: Frontline healthcare providers (HCPs) during the coronavirus disease (COVID-19) pandemic are at high risk of mental morbidity.Objectives: To assess prevalence symptoms anxiety, depression, and peritraumatic dissociation in HCPs.Methods: This was a cross-sectional study 21 ICUs France between April 20, 2020, May 21, 2020. The Hospital Anxiety Depression Scale Peritraumatic Dissociative Experience Questionnaire were used. Factors independently associated with reported health...
Propensity score (PS) methods are increasingly used, even when sample sizes small or treatments seldom used. However, the relative performance of two mainly recommended PS methods, namely PS-matching inverse probability treatment weighting (IPTW), have not been studied in context sizes.We conducted a series Monte Carlo simulations to evaluate influence size, prevalence exposure, and strength association between variables outcome and/or on these methods.Decreasing size from 1,000 40 subjects...
Inverse probability of treatment weighting is a popular propensity score-based approach to estimate marginal effects in observational studies at risk confounding bias. A major issue when estimating the score presence partially observed covariates. Multiple imputation natural handle missing data on covariates: covariates are imputed and analysis performed each dataset effect. The effect estimates from then combined obtain an overall estimate. We call this method MIte. However, alternative has...
Because of the wide variation in course Takayasu arteritis (TA), predicting outcome is challenging. We assess long-term and prognosis factors for vascular complications patients with TA.A retrospective multicenter study characteristics outcomes 318 TA fulfilling American College Rheumatology Ishikawa criteria was analyzed. Factors associated event-free survival, relapse-free incidences were assessed. Risk identified a multivariable model.The median age at diagnosis 36 [25-47] years, 276...
In multilevel settings such as individual participant data meta-analysis, a variable is ‘systematically missing’ if it wholly missing in some clusters and ‘sporadically partly clusters. Previously proposed methods to impute incomplete handle either systematically or sporadically data, but frequently both patterns are observed. We describe new multiple imputation by chained equations (MICE) algorithm for with arbitrary of variables. The described normal can easily be extended other types....
<h3>Importance</h3> Persistent physical and mental disorders are frequent in survivors of COVID-19–related acute respiratory distress syndrome (ARDS). However, data on these among family members scarce. <h3>Objective</h3> To determine the association between patient hospitalization for COVID-19 ARDS vs from other causes risk posttraumatic stress disorder (PTSD)–related symptoms members. <h3>Design, Setting, Participants</h3> Prospective cohort study 23 intensive care units (ICUs) France...
Some of the most potent antiinflammatory and immunosuppressive agents are synthetic glucocorticoids. However, major side effects severely limit their therapeutic use. The development improved glucocorticoid-based drugs will require separation beneficial from deleterious effects. One possibility toward this goal is to try dissociate two main activities glucocorticoids, i.e. transactivation transrepression. Screening a library compounds using AP-1 transrepression models in transiently...
To evaluate the long-term efficacy of anti-hepatitis C virus (HCV) therapy in patients with HCV-associated mixed cryoglobulinemia (HCV-MC) vasculitis and to assess factors associated clinical remission MC.This was a single-center study 72 consecutive who received treatment IFN alfa-2b (3 million IU 3 times week; n = 32 patients) or PEGylated (PEG-IFN alfa-2b) (1.5 mug/kg/week; 40 patients), both combination oral ribavirin (600-1,200 mg/day), for at least 6 months. Logistic regression used...
To test early measurement of human leukocyte antigen-DR expression on circulating monocytes (mHLA-DR) as prognostic marker, and the trend mHLA-DR recovery for prediction late secondary infection risk in a large intensive care unit population.Prospective, observational study over 16 mos.Intensive tertiary teaching hospital.Simplified Acute Physiology Score II >15, age >18 yrs.The was measured by flow cytometry within first 3 days twice week until discharge. We used logistic regression model...
The vasculitis of Behçet disease (BD) is distinctive because involvement both arteries and veins all sizes. concept vasculo-Behçet has been adopted for cases in which vascular manifestations are present often dominate the clinical features. While venous frequent have reported many publications, data regarding arterial lesions patients with BD rare isolated. In this study, we report main characteristics, treatment, long-term outcome 101 among a cohort 820 (12.3%) patients. Factors that affect...