Stéphane Jauréguiberry
A5105834352- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- COVID-19 Clinical Research Studies
- Travel-related health issues
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Viral Infections and Vectors
- Infectious Diseases and Tuberculosis
- Parasite Biology and Host Interactions
- Tuberculosis Research and Epidemiology
- Global Maternal and Child Health
- HIV/AIDS Research and Interventions
- Drug-Induced Hepatotoxicity and Protection
- Diagnosis and treatment of tuberculosis
- Infective Endocarditis Diagnosis and Management
- Research on Leishmaniasis Studies
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Identification and Susceptibility Testing
- Hepatitis Viruses Studies and Epidemiology
- Orthopedic Infections and Treatments
- Leptospirosis research and findings
- Vector-borne infectious diseases
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2015-2025
Bicêtre Hospital
2020-2025
Université Paris-Saclay
2020-2025
Centre de recherche en Epidémiologie et Santé des Populations
2020-2025
Université Paris Cité
2011-2025
Hôpitaux Universitaires Paris-Ouest
2024
Johns Hopkins Hospital
2024
Deutsches Forum für Kunstgeschichte Paris
2021-2023
Sorbonne Université
2014-2023
<h3>Importance</h3> Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19). <h3>Objective</h3> To determine whether tocilizumab (TCZ) improves outcomes patients hospitalized moderate-to-severe COVID-19 pneumonia. <h3>Design, Setting, Particpants</h3> This cohort-embedded, investigator-initiated, multicenter, open-label, bayesian randomized clinical trial investigating moderate or severe requiring at least 3 L/min...
We report data on 11 patients with neurological symptoms and human immunodeficiency virus (HIV) cerebrospinal fluid (CSF) viremia contrasting suppressed plasma HIV RNA during receipt of combined antiretroviral therapy.We retrospectively identified instances central nervous system (CNS) in who had been receiving stable combination therapy. Discordance between CSF levels was defined by any detectable level >200 copies/mL while were <50 or a that 1 log greater than the level.Eleven experienced...
Patients with COVID-19 pneumonia have an excess of inflammation and increased concentrations cytokines including interleukin-1 (IL-1). We aimed to determine whether anakinra, a recombinant human IL-1 receptor antagonist, could improve outcomes in patients hospital mild-to-moderate pneumonia.In this multicentre, open-label, Bayesian randomised clinical trial (CORIMUNO-ANA-1), nested within the CORIMUNO-19 cohort, we recruited from 16 University hospitals France pneumonia, severe acute...
Abstract The largest described outbreak of chikungunya virus has been occurring on the islands southwest Indian Ocean since March 2005. We describe manifestations infection in travelers returning from these islands, with focus skin manifestations.
Abstract Background The optimal duration of antimicrobial therapy for urinary tract infections (UTIs) in men remains controversial. Methods To compare 7 days to 14 total antibiotic treatment febrile UTIs men, this multicenter randomized, double-blind. placebo-controlled noninferiority trial enrolled 282 from 27 centers France. Men were eligible if they had a UTI and urine culture showing single uropathogen. Participants treated with ofloxacin or third-generation cephalosporin at day 1, then...
The efficacy of praziquantel started during the incubation period schistosomiasis has not been studied. Eighteen tourists were infected by Schistosoma haematobium summer 2003 after bathing once in same cascade Mali. We observed given at different phases. They received first consultation, from Days 10 to 15 exposure eight asymptomatic patients (Group 1), 28 40 4 2), and 20 39 6 with acute 3). All Group 1 developed schistosomiasis, compared none 2 (P < 0.004). Among treated phase, clinical...
Artesunate, the recommended drug for severe malaria, rapidly clears malaria parasite from infected patients but frequently induces anemia-called post-artesunate delayed hemolysis (PADH)-for which a simple predictive test is urgently needed. The underlying event in PADH expulsion of artesunate-exposed parasites their host erythrocytes by pitting. We show that histidine-rich protein 2 (HRP2) Plasmodium falciparum persists circulation artesunate-treated Bangladesh and French travelers who...
Artesunate is the most effective treatment for severe malaria. However, delayed-onset hemolytic anemia has been observed in ≈20% of travelers who receive artesunate, ≈60% whom require transfusion. This finding could discourage physicians from using artesunate. We prospectively evaluated a cohort 123 patients France had imported malaria that was treated with artesunate; our evaluation focused on outcome, adverse events, and postartesunate hemolysis (PADH). Of patients, 6 (5%) died. Overall,...
<h3>Importance</h3> Despite annually adapted recommendations to prevent malaria in travelers endemic areas, France is still the industrialized country reporting highest number of imported cases malaria. Better understanding epidemiologic context and evolution during past 2 decades may help define a better preventive strategy. <h3>Objective</h3> To study trends geographic territories on European continent (metropolitan France) from 1996 through 2016 potentially explain persistence high...
In Plasmodium falciparum-infected patients treated with artemisinins, parasitemia declines through so-called pitting, an innate splenic process that transforms infected red blood cells (iRBCs) into once-infected RBCs (O-iRBCs). We measured pitting in 83 French travelers and 42 Malian children for malaria artesunate. travelers, O-iRBCs peaked at 107.7% initial parasitemia. aged 1.5-4 years, higher concentrations than 9-13 years (91.60% vs 31.95%; P = .0097). The parasite clearance time older...
Among patients hospitalized for novel coronavirus disease (COVID-19), between 10 and 14% develop an acute kidney injury around half display marked proteinuria haematuria. Post-mortem analyses of COVID-19 tissue suggest that renal tubular cells podocytes are affected. Here we report two cases collapsing glomerulopathy tubulointerstitial lesions in living patients. Despite our use sensitive reverse transcription polymerase chain reaction techniques this study, failed to detect the virus blood,...
Encephalitis and focal neurologic deficits can occur during the acute phase of schistosomiasis. We report two cases in which cerebral imaging showed vasculitis located arterial junctional territories. These complications may be caused by eosinophil-mediated toxicity. Immediate treatment should consist corticosteroids rather than specific antischistosomal drugs, aggravate disorders.
Abstract Chagas disease (CD) is endemic to Latin America; its prevalence highest in Bolivia. CD sometimes seen the United States and Canada among migrants from America, whereas it rare Europe. We report 9 cases of imported France 2004 2006.
The spectrum of dermatoses occurring in travelers returning from tropical areas is poorly documented. We analyzed the relative frequency travel-associated and their possible relationships to travel characteristics all persons who came our hospital between November 2002 May 2003 for a cutaneous disorder related country. One hundred sixty-five were included. main identified infectious cellulitis (12.7%), scabies (10.3%), pruritus unknown origin (PUO) (9.1%). Tropical accounted 33.9% disorders....
Abstract In a retrospective multicenter study of 575 patients with bloodstream infections or pneumonia due to wild-type AmpC β-lactamase–producing Enterobacterales, species low in vitro mutation rates for derepression were associated fewer treatment failures overproduction (adjusted hazard ratio, 0.5 [95% CI, .2–.9]). However, compared cefepime/carbapenems, using third-generation cephalosporins as definitive therapy remained this adverse outcome (15% vs 1%).