A5074186237- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Viral Infections and Immunology Research
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Polyomavirus and related diseases
- Renal cell carcinoma treatment
- Renal and Vascular Pathologies
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Infective Endocarditis Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Organ Donation and Transplantation
- Organ and Tissue Transplantation Research
- Hepatitis C virus research
- Cardiovascular Issues in Pregnancy
- Nitric Oxide and Endothelin Effects
- Cardiac Arrest and Resuscitation
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Congenital Heart Disease Studies
Hôpital Bichat-Claude-Bernard
2015-2025
Assistance Publique – Hôpitaux de Paris
2012-2025
Agence de la Biomédecine
2016-2025
Inserm
2001-2023
Université Paris Cité
2004-2023
Université Claude Bernard Lyon 1
2000-2023
Hôpital Tenon
2008-2022
Sorbonne Université
2008-2022
Délégation Paris 7
2012-2016
Sorbonne Paris Cité
2016
Everolimus, a novel proliferation inhibitor and immunosuppressive agent, may suppress cardiac-allograft vasculopathy. We conducted randomized, double-blind, clinical trial comparing everolimus with azathioprine in recipients of first heart transplant.A total 634 patients were randomly assigned to receive 1.5 mg per day (209 patients), 3.0 (211 or 1.0 kilogram body weight (214 combination cyclosporine, corticosteroids, statins. The primary efficacy end point was composite death, graft loss...
Dilated cardiomyopathy (DCM) is a major cause of heart failure with high familial recurrence risk. So far, the genetics DCM remains largely unresolved. We conducted first genome-wide association study (GWAS) to identify loci contributing sporadic DCM. One thousand one hundred and seventy-nine patients 1108 controls contributed discovery phase. Pools DNA stratified on disease status, population, age, gender were constituted used for testing 517 382 single nucleotide polymorphisms (SNPs)....
PURPOSE Organ recipients are at a high risk of posttransplant lymphoproliferative disorders (PTLD) as result immunosuppressive therapy. Most B-cell lymphomas associated with Epstein-Barr virus (EBV) infection. We describe morphologically and clinically distinct group PTLD in 11 patients that occurred late after organ transplantation were not EBV. PATIENTS AND METHODS There seven kidney, three heart, one liver transplant (group I). The clinical manifestations, pathologic findings, treatment,...
Photopheresis is an immunoregulatory technique in which lymphocytes are reinfused after exposure to a photoactive compound (methoxsalen) and ultraviolet A light. We performed preliminary study assess the safety efficacy of photopheresis prevention acute rejection cardiac allografts.
Organ recipients are at a high risk of post-transplant lymphoproliferative disorders (PTLDs) as complication immunosuppressive therapy. We report the incidence, clinical presentation, pathologic findings, treatment, and outcome for 24 cases PTLD observed our institution.Twenty-four (1.7%) 1,385 organ transplant developed PTLDs. Dosages drugs were reduced in 19 patients. Treatment consisted anti-B-cell monoclonal antibodies (12 patients), and/or chemotherapy (eight or surgery (two...
PURPOSE: Prognostic studies of posttransplantation lymphoproliferative disorders (PTLDs) are hindered by the small number cases at each transplant center. We analyzed prognostic factors and long-term outcome according to clinical manifestations, pathologic features, treatment investigated value non-Hodgkin’s lymphoma International Index (IPI) in 61 patients with PTLD. PATIENTS AND METHODS: studied two institutions who developed PTLD influencing complete remission survival rates. RESULTS: In...
Our objective was to better understand the genetic bases of dilated cardiomyopathy (DCM), a leading cause systolic heart failure.
Importance The US heart allocation system prioritizes medically urgent candidates with a high risk of dying without transplant. current therapy-based 6-status is susceptible to manipulation and has limited rank ordering ability. Objective To develop validate candidate score that incorporates clinical, laboratory, hemodynamic data. Design, Setting, Participants A registry-based observational study adult transplant (aged ≥18 years) from the listed between January 1, 2019, December 31, 2022,...
Background. The yearly increasing survival rates testify to the success of transplantation, but questions remain relating quality life (QOL) associated with long-term survival. Methods. A sample 126 liver recipients (Liver-R), 229 kidney (Kidney-R), and 113 heart (Heart-R) more than 10 years posttransplant follow-up were included in study a response rate 86%. Respondents matched healthy subjects recruited from general population (GP). three groups GP completed French version questionnaire...
Background: Pulmonary hypertension (PH) is characterized by an increase in vascular tone and abnormal proliferation of muscle cells the walls pulmonary arteries. Recent studies have found high plasma endothelin-1 (ET-1) concentrations patients with PH. This study was conducted to assess whether elevated circulating ET-1 levels PH really reflect excessive local production. Methods: We prospectively studied concentration lung specimens from 6 control subjects 13 severe referred for or...
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used as a short-term circulatory support in patients with refractory cardiogenic shock providing bridge to long-term mechanical or transplantation. In France, higher priority status granted transplant candidates on VA-ECMO than those support. This study aimed evaluate the impact of transplantation primary therapy survival at listing.This was retrospective analysis data from French national registry CRISTAL including...
Graft allocation rules for heart transplantation are necessary because of the shortage donors, resulting in high waitlist mortality. The Agence de la biomédecine is agency charge organ system France. Assessment 2004 urgency-based identified challenging limitations. A new based on a score ranking all candidates was implemented January 2018. In revised system, medical urgency defined according to candidate characteristics rather than treatment modalities, and an interplay between urgency,...
Infectious complications are a major cause of morbidity and mortality after heart transplantation (HT). However, the epidemiology outcomes these infections in recent population adult transplant recipients have not been investigated. We conducted single-center retrospective study on infectious occurring within 180 days following HT consecutive recipients, from January 2011 to June 2015 at Bichat University Hospital Paris, France. Risk factors for non-viral 8, 30 were investigated using...
The prognostic value of 'high dose' loop diuretics in advanced heart failure outpatients is unclear. We aimed to assess the prognosis associated with diuretic dose ambulatory patients awaiting transplantation (HT).
To describe the clinical features of Kaposi sarcoma (KS) in organ-allograft recipients and to determine contribution human herpesvirus 8 (HHV-8) investigations management KS.We examined 20 with KS at Pitié-Salpêtrière Hospital, Paris, France, between November 1, 1991, May 31, 1999.We detected HHV-8 antibodies using an indirect immunofluorescence assay DNA genome nonnested polymerase chain reaction KS-associated 330(233) primers peripheral blood mononuclear cells collected transplantation...