A5019575404- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Transplantation: Methods and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Organ Donation and Transplantation
- Alcohol Consumption and Health Effects
- Cytomegalovirus and herpesvirus research
- Renal function and acid-base balance
- Acute Kidney Injury Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- HIV/AIDS drug development and treatment
- Electrolyte and hormonal disorders
- Poisoning and overdose treatments
- Genetic and Kidney Cyst Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Polyomavirus and related diseases
- Metabolism and Genetic Disorders
- Pulmonary Hypertension Research and Treatments
Hôpital Beaujon
2016-2025
Inserm
2016-2025
Université Paris Cité
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Centre de Recherche sur l'Inflammation
2016-2025
Délégation Paris 7
2013-2024
Nokia (France)
2023-2024
Gilead Sciences (France)
2017-2024
Rajagiri Hospital
2023
Centre Hospitalier Universitaire de Grenoble
2001-2022
In Brief Objective: To standardize the definition of postoperative liver failure (PLF) for prediction early mortality after hepatectomy. Summary Background Data: The PLF is not standardized, making comparison innovations in surgical techniques and timely use specific therapeutic interventions complex. Methods: Between 1998 2002, 775 elective resections, including 69% malignancies 60% major were included a prospective database. nontumorous was abnormal 43% with steatosis >30% 14%,...
A 6-month abstinence from alcohol is usually required before patients with severe alcoholic hepatitis are considered for liver transplantation. Patients whose not responding to medical therapy have a survival rate of approximately 30%. Since most deaths occur within 2 months, early transplantation attractive but controversial.We selected seven centers The had no prior episodes and scores 0.45 or higher according the Lille model (which calculates ranging 0 1, score ≥ indicating nonresponse an...
Acute renal failure (ARF) is a common complication in patients with decompensated cirrhosis. The traditional diagnostic criteria of these were proposed 19961 and have been refined subsequent years.2 According to criteria, ARF defined as an increase serum creatinine (sCr) ≥50% from baseline final value >1.5 mg/dL (133 µmol/L). However, the threshold 1.5 mg/dL (133 µmol/L) sCr define cirrhosis has challenged.3 ,4 In addition, timeframe distinguish acute chronic not clearly identified, only...
Acute-on-chronic liver failure (ACLF) in cirrhosis is characterized by acute decompensation (AD), organ failure(s), and high short-term mortality. Recently, we have proposed (systemic inflammation [SI] hypothesis) that ACLF the expression of an exacerbation SI already present decompensated cirrhosis. This study was aimed at testing this hypothesis included 522 patients with (237 ACLF) 40 healthy subjects. assessed measuring 29 cytokines redox state circulating albumin (HNA2), a marker...
Acute‐on‐chronic liver failure (ACLF) is characterized by acute decompensation (AD) of cirrhosis, organ failure(s), and high 28‐day mortality. We investigated whether assessments patients at specific time points predicted their need for transplantation (LT) or the potential futility care. assessed clinical courses 388 who had ACLF enrollment, from February through September 2011, during early (28‐day) follow‐up prospective multicenter European Chronic Liver Failure (CLIF) in Cirrhosis study....
Abstract Beta-blockers may have a negative impact on survival in patients with cirrhosis and refractory ascites. The aim of this study was to evaluate the effect administration beta-blockers long-term We performed single-center, observational, case-only, prospective ascites who did or not receive for prevention gastrointestinal bleeding; 151 were included. mean Model End-Stage Liver Disease score 18.8 ± 4.1. All regularly underwent large-volume paracentesis intravenous albumin...
Acute renal failure (ARF) is a common complication in patients with decompensated cirrhosis. The traditional diagnostic criteria of these were proposed 19961 and have been refined subsequent years.2 According to criteria, ARF defined as an increase serum creatinine (sCr) ≥50% from baseline final value >1.5 mg/dL (133 µmol/L). However, the threshold 1.5 mg/dL (133 µmol/L) sCr define cirrhosis has challenged.3 ,4 In addition, timeframe distinguish acute chronic not clearly identified, only...
To evaluate the feasibility and postoperative course of liver transplantation (LT) in cirrhotic patients who underwent resection prior to LT for HCC.Although provides longer survival than treatment small HCCs, donor shortage long wait time may argue against LT. The following after hepatic have not been previously examined.Between 1991 2001, among 107 HCC, 88 met Mazzafero's criteria upon pathologic analysis explant. Of these, 70 primary (PLT) 18 secondary (SLT) recurrence (n = 11),...
Chinese translation Background: Albumin dialysis with the Molecular Adsorbent Recirculating System (MARS) (Gambro, Lund, Sweden), a noncell artificial liver support device, may be beneficial in acute failure (ALF). Objective: To determine whether MARS improves survival ALF. Design: Randomized, controlled trial. (ClinicalTrials.gov: NCT00224705) Setting: 16 French transplantation centers. Patients: 102 patients Intervention: Conventional treatment (n = 49) or conventional 53), stratified...
Liver resection (LR) for hepatocellular carcinoma (HCC) as the first–line treatment in transplantable patients followed by “salvage transplantation” (ST) case of recurrence is an attractive concept. The aim was to identify who gain benefit from this approach intention–to–treat study. From 1998 2008, among 329 potential candidates liver transplantation (LT) with HCC within Milan criteria (MC), 138 good function were resected (LR group) a perspective ST recurrence, and 191 listed LT first (LT...