A5003185787- Finance, Taxation, and Governance
- Liver Disease and Transplantation
- Corporate Taxation and Avoidance
- Liver Disease Diagnosis and Treatment
- Taxation and Legal Issues
- Organ Transplantation Techniques and Outcomes
- Administrative Law and Governance
- Drug-Induced Hepatotoxicity and Protection
- Latin American Legal and Economic Studies
- Comparative International Legal Studies
- Criminal Justice and Penology
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Renal function and acid-base balance
- Oral Health Pathology and Treatment
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Acute Kidney Injury Research
- Human Rights and Immigration
- Political and Social Dynamics in Chile and Latin America
- Adrenal Hormones and Disorders
- Food Allergy and Anaphylaxis Research
- Hormonal Regulation and Hypertension
- Comparative constitutional jurisprudence studies
- Accounting and Financial Management
European Foundation for the Study of Chronic Liver Failure
2018-2025
Universitat de Barcelona
2013-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2010-2025
Hospital Clínic de Barcelona
2002-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2006-2025
Centro de Investigación Biomédica en Red
2023-2025
Grifols (Spain)
2019-2025
Centro de Estudios Científicos
2018-2024
University of Milano-Bicocca
2022
Alberto Hurtado University
2016-2021
Spontaneous bacterial peritonitis (SBP) is frequently associated with renal failure. This study assessed if systemic and hepatic hemodynamics are also affected by this condition. Standard laboratory tests, tumor necrosis factor alpha (TNF-alpha) in plasma ascitic fluid, renin activity (PRA) norepinephrine (NE), were determined 23 patients SBP at diagnosis after resolution of infection. Eight developed failure during treatment. At infection, developing showed significantly higher values...
Relative adrenal insufficiency is frequent in patients with severe sepsis and associated hemodynamic instability, renal failure, increased mortality. This study prospectively evaluated the effects of steroids on shock resolution hospital survival a series 25 consecutive cirrhosis septic (group 1). Adrenal function was by short corticotropin test within first 24 hours admission. Patients were treated stress doses intravenous hydrocortisone (50 mg/6 h). Data compared to those obtained from...
Background and Aims Patients with liver disease acquire complex changes in their hemostatic system, which results a fragile rebalanced status. The status of the fibrinolytic system is controversial, as role dysfunction bleeding thrombosis patients cirrhosis. Here, we aimed to determine its relationship outcome acutely ill Approach Results We assessed plasma potential large cohort decompensated cirrhosis (AD, n = 52) or acute‐on‐chronic failure (ACLF, 57). Compared 40 healthy volunteers,...
Background and aims Current prognostic scores of patients with acutely decompensated cirrhosis (AD), particularly those acute-on-chronic liver failure (ACLF), underestimate the risk mortality. This is probably because systemic inflammation (SI), major driver AD/ACLF, not reflected in scores. SI induces metabolic changes, which impair delivery necessary energy for immune reaction. investigation aimed to identify metabolites associated short-term (28-day) death design metabolomic models....
Type-1 hepatorenal syndrome (HRS) is a common complication of bacterial infections in cirrhosis, but its natural history remains undefined. To assess the outcome kidney function and survival patients with type-1 HRS associated infections, 70 diagnosed during 6-year period were evaluated prospectively. Main outcomes no reversibility treatment infection 3-month survival. Forty-seven (67%) had infection. [Correction to previous sentence added March 10, 2014, after first online publication:...
Background. Critically ill cirrhotic patients are increasingly transplanted, but there is no consensus about futile liver transplantation (LT). Therefore, the decision to delay or deny LT often extensively debated. These debates arise from different opinions of futility among transplant team members. This study aims achieve a multinational and multidisciplinary on definition in develop well-articulated criteria for not proceeding with due futility. Methods. Thirty-five international experts...
There is growing evidence that liver transplantation (LT) the most effective treatment for acute-on-chronic failure grade-3 (ACLF-3). This study examines whether and how this translates into practice by analyzing variability in intensive care unit (ICU) admissions, listing strategies, LT activity patients with ACLF-3 across centers Europe. Consecutive who were admitted to ICU ACLF-3, or not they listed and/or transplanted between 2018 2019 included 20 centers. A total of 351 included: 33 had...
Acute-on-chronic liver failure (ACLF) is a major clinical event in cirrhosis that characterized by high mortality rates and short window for transplantation (LT). N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been suggested as prognostic biomarker cirrhosis. However, its accuracy predicting the development of ACLF or LT candidates remains unknown. This observational, retrospective, single-center study included 277 consecutive patients with who were listed between 2014 2020...
Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim this study was determine SARS-CoV-2 liver (LT) kidney (KT) compare it with adult A European, prospective, multicenter performed. Samples were taken at 7 32 wk following COVID-19 endpoints measured by ELISA. total 42 (16...
To assess the efficacy and safety of nonsurgical treatment with imiquimod (IMQ) 5% cream in patients periocular nodular basal cell carcinoma (BCC).Fifteen clinical histopathological diagnosis BCC on eyelid were treated IMQ once daily, 5 days/week for 6 weeks. Three had tumor persistence after photodynamic therapy 1 patient failed cryotherapy.All tumors showed remission within 3 months starting IMQ, sustained was documented each 24-28 months' follow-up. Treatment tolerability bad 7 local...
The Human Cell Differentiation Molecules (HCDM) organizes Leukocyte Antigen (HLDA) workshops to test and name clusters of antibodies that react with a specific antigen. These cluster differentiation (CD) markers have provided the scientific community validated antibody clones, consistent naming targets reproducible identification leukocyte subsets. Still, quantitative CD marker expression profiles benchmarking reagents at single-cell level are currently lacking. To develop flow cytometric...
Abstract Objectives Physiopathological changes in advanced cirrhosis could alter tigecycline pharmacokinetics (PK), thus affecting serum drug concentrations and compromising target attainment. We aimed to describe PK patients with decompensated severe bacterial infections, identify the sources of variability assess performance different dosing regimens optimize PK/pharmacodynamic (PD) target. Methods Serum covariates were obtained from infections under treatment. A population analysis was...
Atopic dermatitis (AD) is a protease-modulated chronic disorder with heterogenous clinical manifestations which may lead to an imprecise diagnosis. To date, there are no diagnostic protease tests for AD. We explored the gingival crevicular fluid (GCF) profile of individuals moderate/severe AD compared healthy controls. An exploratory case-control study was conducted. patients (n = 23) and controls 21) were enrolled at International Center Clinical Studies, Santiago, Chile. Complete...