A5052724921- Sexual Differentiation and Disorders
- Urological Disorders and Treatments
- Pancreatic function and diabetes
- Metabolism and Genetic Disorders
- Diabetes Management and Research
- Obesity, Physical Activity, Diet
- Renal and Vascular Pathologies
- Urologic and reproductive health conditions
- Diet and metabolism studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer, Hypoxia, and Metabolism
- Malaria Research and Control
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Renal Diseases and Glomerulopathies
- Hemoglobinopathies and Related Disorders
- Diabetes and associated disorders
- Growth Hormone and Insulin-like Growth Factors
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hepatitis B Virus Studies
- Ion Transport and Channel Regulation
- Infective Endocarditis Diagnosis and Management
All India Institute of Medical Sciences
2016-2025
Foundation for Liver Research
2023-2025
King's College London
2025
Williams (United Kingdom)
2025
Northwestern University
2023-2024
Sanjay Gandhi Post Graduate Institute of Medical Sciences
1999-2023
Post Graduate Institute of Medical Education and Research
2018-2023
Indira Gandhi Medical College
2005-2022
National Institute of Ayurveda
2022
Creative Commons
2018-2021
Abstract Background 46,XY gonadal dysgenesis is classified as complete (CGD) or partial (PGD) subtypes. The phenotype of PGD and the long-term outcome not clearly defined. Objective To evaluate clinical features pubertal in a large cohort, using CGD comparator for diagnostic clarity. Methods Patients with GD were identified from I-DSD Registry data on phenotype, genetics, biochemistry, histology development collated three categories; (n=100), assigned female (PGDf, n=107) male (PGDm, n=103)...
Aims: The aim was to study the clinical profile, risk factors prevalence, angiographic distribution, and severity of coronary artery stenosis in acute syndrome (ACS) patients South Indian population. Materials Methods: A total 1562 ACS were analyzed for various factors, pattern heart disease, complications hospital mortality at Sri Jayadeva Institute Cardiovascular Research Sciences, Bengaluru, Karnataka, India. Results: Mean age presentation 54.71 ± 19.90 years. Majority male 1242 (79.5%)...
This study was conducted to evaluate the safety and efficacy of tacrolimus (TAC) in children with SRNS. The group comprised 22 consecutive steroid-resistant nephrotic syndrome (SRNS) who were studied prospectively. TAC initiated a dose 0.10 mg/kg/day, increased attain trough level 5.0–10.0 g/l. These patients treated concomitant prednisone, which subsequently tapered off stopped. primary outcome variable number attained complete remission (CR) or partial (PR). mean age onset 7.33 ± 5.9...
Mesenchymal stem cell (MSC) therapy is an innovative approach in diabetes due to its capacity modulate tissue microenvironment and regeneration of glucose-responsive insulin-producing cells. In this study, we investigated the role MSC-derived exosomes pancreatic insulin secretion mice with streptozotocin-induced diabetes. cells (MSCs) were isolated characterized from umbilical cord blood (UCB). Exosomes these MSCs. Diabetes was induced male C57Bl/6 by streptozotocin (STZ; 40 mg/kg body...
Abstract Background 46, XY disorders of sex development (DSD) are a group highly heterogeneous conditions in which the molecular etiology remains unknown significant proportion patients, even with massive parallel sequencing. Clinically copy number variants (CNVs) identified 20−30% cases, particularly among those gonadal dysgenesis (GD) and no diagnosis. Methods Fourteen patients DSD due to GD whom pathogenic/likely pathogenic were found on next‐generation sequencing using targeted panel 155...
Acute kidney injury (AKI) is a major health concern and well-established risk factor for the development of chronic disease (CKD). Tissue hypoxia prominent feature injured that shapes biological behavior parenchymal immune cells. Endothelial cells have important immunomodulatory roles, but impact dysregulated oxygen sensing on their responses remains poorly understood. By leveraging combination conditional mouse strains, single-cell analyses human samples, in vitro experiments, we...
Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim this study was determine SARS-CoV-2 liver (LT) kidney (KT) compare it with adult A European, prospective, multicenter performed. Samples were taken at 7 32 wk following COVID-19 endpoints measured by ELISA. total 42 (16...
Kidney disease is prevalent in diabetes. Urinary exosomes (uE) from animal models and patients with Diabetic nephropathy (DN) showed increased levels of miRs reno-protective potential. We examined whether urinary loss such associated their reduced renal DN patients. also tested injecting uE can leverage kidney rats. In this study (study-1) we performed microarray profiling miRNA tissues subjects diabetes without (controls). study-2, was induced Wistar rats by Streptozotocin (i.p. 50 mg/kg...
Background: Cancer is a word that strikes fear into people and something completely changes their lives its effects touch everyone involved. The main objective of the study to assess coping strategies used by parents children with cancer. Subjects Methods: A total 60 caregivers cancer healthy participated in study. Informed consent was taken were assessed on sociodemographic parameters, measured using ways scale-revised. Results: mean age 9.98 (standard deviation-1.85) years. About half...
Impaired insulin-induced suppression of renal gluconeogenesis could be a risk for hyperglycemia. Diabetes is associated with elevated gluconeogenesis; however, its regulation in early insulin resistance unclear humans. A noninvasive marker would helpful. Here, we show that human urine exosomes (uE) contain three gluconeogenic enzymes: phosphoenolpyruvate carboxykinase (PEPCK), fructose 1,6-bisphosphatase, and glucose 6-phosphatase. Their protein levels were positively whole body sensitivity....
Objective: To describe physical growth and related factors in transfusion-dependent thalassemia patients. Methods: This is a cross-sectional analysis of the records patients registered at being followed up by Thalassemia Day Care Center (TDCC) Kalawati Saran Children's Hospital, New Delhi, India. Clinical laboratory parameters were recorded on spreadsheet for analysis. included weight, height, sexual maturity ratings, general systemic examination. Laboratory pretransfusion hemoglobin (Hb),...
Background Regular blood transfusion and iron chelation are the standard of care for children with thalassemia. Deferiprone is an effective oral chelator but known to cause significant arthropathy. Though clinical radiographic features deferiprone related arthropathy have been described, long-term effects not known. Procedure Routine radiographs left wrist hand done bone age estimation in 40 thalassemia were evaluated revealed unique changes 13 (10 males: 3 females) previous or current...