Francesco Paolo Russo
A5027631947- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Renal Transplantation Outcomes and Treatments
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Prostate Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Alcohol Consumption and Health Effects
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Lung Cancer Treatments and Mutations
- Tissue Engineering and Regenerative Medicine
- Diet and metabolism studies
- Mesenchymal stem cell research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Azienda Ospedaliera di Padova
2010-2025
University of Padua
2016-2025
Institute for Experimental Endocrinology and Oncology
2022-2024
National Research Council
2022-2024
Regione del Veneto
2018-2024
Gastroenterology Hospital "Saverio de Bellis"
1997-2023
The Geneva Association
2023
European Association for the Study of the Liver
2023
University of Oxford
2023
Magna Graecia University
2023
Central to fibrogenesis and the scarring of organs is activation fibroblasts into matrix-secreting myofibroblasts. We demonstrate that Galectin-3 expression up-regulated in established human fibrotic liver disease temporally spatially related induction resolution experimental hepatic fibrosis. Disruption gene blocks myofibroblast procollagen (I) vitro vivo , markedly attenuating Addition exogenous recombinant reversed this abnormality. The reduction fibrosis observed −/− mouse occurred...
Hepatocellular carcinoma (HCC) is a major cause of morbidity and mortality in patients with advanced chronic liver disease (ACLD) caused by hepatitis C who have achieved sustained virologic response (SVR). We developed risk stratification algorithms for de novo HCC development after SVR validated them an independent cohort.We evaluated the occurrence derivation cohort 527 pre-treatment ACLD to interferon-free therapy, whom alpha-fetoprotein (AFP) non-invasive surrogates portal hypertension...
The over-expression of epidermal growth factor receptor (EGF-R), EGF and transforming alpha (TGFalpha) could be a mechanism for colorectal tumor cells to escape normal controls. Our aims were: (i) evaluate EGF, TGFalpha, EGF-R concentrations in neoplastic tissue surrounding mucosa from 40 patients with adenocarcinoma, (ii) assess the expression these factors their relation site. were detected either or mucosa. Significantly increased levels present samples compared Furthermore, significant...
A series of 45 patients with chylous ascites has been reviewed. The age at presentation ranged from 1 to 80 (median 12) years; 23 were aged < or = 15 years. Thirty-five had an abnormality the lymphatics (primary ascites); in remaining ten, was secondary other conditions, principally non-Hodgkin's lymphoma (six patients). Two principal mechanisms formation identified using lymphangiography and inspection laparotomy: leakage retroperitoneal megalymphatics, usually through a visible...
Few data are available on the virological and clinical outcomes of advanced liver disease patients retreated after first-line DAA failure.
Background and Aims: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated better long-term outcome. However, second-line therapies currently recommended only when ALP remain above 1.5 times the upper limit of normal (×ULN) after 12-month UDCA. We assessed whether, considered good responders to UDCA, were significant survival gains. Approach Results: performed a retrospective cohort study 1047 PBC who...
Abstract Background The role of the gut‐brain axis has been recently highlighted as a major contributor to Parkinson's disease (PD) physiopathology, with numerous studies investigating bidirectional transmission pathological protein aggregates, such α‐synuclein (αSyn). However, extent and characteristics pathology in enteric nervous system have not fully investigated. Objective We characterized αSyn alterations glial responses duodenum biopsies patients PD by employing topography‐specific...
Baveno VII has defined a clinically significant (i.e., prognostically meaningful) decrease in liver stiffness measurement (LSM) cACLD as of ≥20% associated with final LSM <20 kPa or any to <10 kPa. However, these rules have not yet been validated against direct clinical endpoints.