A5073184848- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Liver Disease Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- Liver Diseases and Immunity
- Amoebic Infections and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal motility and disorders
- Parasites and Host Interactions
- Colorectal Cancer Screening and Detection
- Urological Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Cystic Fibrosis Research Advances
- Multiple Myeloma Research and Treatments
- Anesthesia and Sedative Agents
- Alcohol Consumption and Health Effects
- Pancreatitis Pathology and Treatment
- Intensive Care Unit Cognitive Disorders
- Renal and Vascular Pathologies
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Anesthesia and Neurotoxicity Research
University Hospital of Zurich
2018-2025
University of Zurich
2022-2024
Medical University of Vienna
2022
Mayo Clinic in Arizona
2012
Background and Aims: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated better long-term outcome. However, second-line therapies currently recommended only when ALP remain above 1.5 times the upper limit of normal (×ULN) after 12-month UDCA. We assessed whether, considered good responders to UDCA, were significant survival gains. Approach Results: performed a retrospective cohort study 1047 PBC who...
Aims Infections by the larval stage of tape worms Echinococcus multilocularis and granulosus s.l . are potentially fatal zoonoses affecting humans as dead‐end hosts. Histopathological evaluation hepatic echinococcosis is an integral part patient management, including distinction between alveolar (AE) cystic (CE), which associated with different disease courses treatments. To improve histopathological assessment lesions, we aimed to develop robust criteria evaluate their viability decay....
Although the two-kidney, one-clip (2K1C) model is widely used as a of human renovascular hypertension, mechanisms leading to development fibrosis and atrophy in cuffed kidney compensatory hyperplasia contralateral have not been defined. Based on well-established role transforming growth factor (TGF)-β signaling pathway renal fibrosis, we tested hypothesis that abrogation TGF-β/Smad3 would prevent kidney. Renal artery stenosis (RAS) was established mice with targeted disruption exon 2 Smad3...
Background and AimsThe role of decreased pyloric distensibility in gastroparesis as measured by the endolumenal functional luminal imaging probe (EndoFLIP) has been receiving increasing attention. In this study, we present clinical outcomes to dilation with esophageal FLIP (EsoFLIP) regard gastric emptying, symptom evolution, metrics.MethodsPatients evaluated for (gastric emptying studies t1/2 ≥180 minutes during 13C-octanoic acid breath test and/or remnants gastroscopy after a sufficient...
Alveolar echinococcosis (AE) is a zoonotic disease of increasing concern worldwide. Before benzimidazole drug therapy, 10-year death rates were 90% without surgical resection. In unresectable patients, long-term therapy highly effective in stabilizing the course. We performed retrospective study 334 AE patients treated at University Hospital Zurich, Switzerland, during 1973-2022. Annual diagnoses increased over time, and more cases detected by chance earlier stages. Ninety died, mostly from...
Both alveolar (AE) and cystic echinococcosis (CE) are lacking pathognomonic clinical signs; consequently imaging technologies serology remain the main pillars for diagnosis. The present study included 100 confirmed treatment-naïve AE 64 CE patients that were diagnosed in Switzerland or Kyrgyzstan. Overall, 10 native Echinococcus spp. antigens, 3 recombinant 4 commercial assays comparatively evaluated. All E. multilocularis antigens produced duplicates with a European Kyrgyz isolate showed...
Direct-acting antivirals (DAAs) have revolutionised the management of chronic hepatitis C. We analysed use different generations DAAs over time in Switzerland and investigated factors predictive treatment failure.
Alveolar echinococcosis (AE) caused by Echinococcus multilocularis , is a severe zoonotic disease in humans. One of the major metacestode antigens E. Em2 or Em2(G11) native purified antigen. The antigen used for serological and histopathological diagnosis AE humans plays an important role parasite–host interactions. As mucin-type glycosylated protein, protein backbone has not been identified yet. We have targeted identification through mass spectrometry (LC-MS/MS) analysis result, we...
Objectives Alveolar echinococcosis (AE) is an orphan zoonosis of increasing concern in endemic areas, including Europe. It frequently presents advanced, inoperable stage, that requires life-long parasitostatic benzimidazole therapy. In some patients, long-term therapy leads to negative anti-Em18 antibody ELISA and PET. disputed, whether these patients are truly cured treatment can be safely discontinued. Our aim was retrospectively assess outcome 34 with AE who participated a previous study...
Abstract Purpose To compare the diagnostic performance of T1 mapping and MR elastography (MRE) for staging hepatic fibrosis grading inflammation with histopathology as standard reference. Methods 68 patients various liver diseases undergoing biopsy suspected or an established diagnosis cirrhosis prospectively underwent look-locker inversion recovery MRE. relaxation time stiffness (LS) were measured by two readers. Hepatic histopathologically staged according to a standardized (F0–F4) (A0–A2)...
Alveolar (AE) and cystic echinococcosis (CE) are severe parasitic zoonoses caused by the larval stages of Echinococcus multilocularis E. granulosus sensu lato , respectively. A panel 7 monoclonal antibodies (mAbs) was selected against major diagnostic epitopes both species. The binding capacity mAbs to spp. excretory/secretory products (ESP) analyzed sandwich-ELISA, where mAb Em2G11 EmG3 detected in vitro extravesicular ESP s.s. These findings were subsequently confirmed detection...
Background and AimsScreening for colorectal cancer (CRC) can effectively reduce CRC incidence mortality. Besides colonoscopy, tests the detection of biomarkers in stool, blood, or serum, including fecal immunochemical test (FIT), ColoGuard, Epi proColon, PolypDx, have recently been advanced. We aimed to identify characteristics theoretic, highly efficient screening calculated effectiveness cost available tests.MethodsUsing microsimulation-based colon modeling open-source tool (CMOST), we...
In primary biliary cholangitis (PBC), static liver stiffness measurement (LSM) has proven prognostic value. However, the added value of LSM time course in this disease remains uncertain.
Alveolar echinococcosis is a rare parasitic disease, most frequently affecting the liver, as slow-growing tumor-like lesion. If inoperable, long-term benzimidazole therapy required, which associated with high healthcare costs and occasionally increased morbidity. The aim of our study was to determine role 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in staging patients alveolar identify quantitative imaging parameters related patient outcome and/or...
Since the change in millennium, an increase cases of alveolar echinococcosis (AE) has been observed endemic European countries. Previous studies indicate that a significant proportion new AE have immunosuppression-associated condition (IAC). The aim current study was to determine how IACs impact number diagnoses per year and characteristics at diagnosis its clinical course our center.Retrospective analysis 189 patients with diagnosed between 2000 2021 participating Zurich Echinococcosis...
To investigate the potential role of follow-up 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in therapy control inoperable patients with alveolar echinococcosis.In this single-center retrospective cohort study, 48 PET/CT 16 confirmed echinococcosis were analysed. FDG-uptake most active manifestation was measured (i.e., maximum standardized uptake value (SUVmax) and relation to background activity normal liver tissue (SUVratio)) compared...
We present dynamic 18 F-FDG PET/CT acquisition in a 52-year-old old woman with histologically proven hepatic alveolar echinococcosis (AE). Metabolic rate of FDG images generated traditional and relative Patlak analysis show the AE manifestation liver significantly better static SUV images. Dynamic PET may thus have potential to increase sensitivity assessment manifestations. Such parametric offer complementary qualitative information quantification superior
Delirium is the most common acute neuropsychiatric syndrome in hospitalized patients. Higher age and cognitive impairment are known predisposing risk factors general hospital populations. However, interrelation with precipitating gastrointestinal (GI) hepato-pancreato-biliary (HPB) diseases remains to be determined.Prospective 1-year hospital-wide cohort study 29'278 adults, subgroup analysis 718 patients GI/HPB disease. based on routine admission screening a DSM-5 construct. Regression...
Alveolar echinococcosis, an orphan zoonosis affecting the liver, is of increasing concern worldwide. Most symptomatic cases present at advanced and inoperable stage, sometimes with biliary obstruction prompting tract interventions. These are, however, associated a high risk infectious complications. The aim this retrospective study was to compare effectiveness safety conservative interventional treatment approaches in patients newly diagnosed alveolar echinococcosis obstruction.Alveolar...