A5084069127- Parasites and Host Interactions
- Parasitic infections in humans and animals
- Parasite Biology and Host Interactions
- Parasitic Infections and Diagnostics
- Extracellular vesicles in disease
- Congenital Anomalies and Fetal Surgery
- Helminth infection and control
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Amoebic Infections and Treatments
- Vector-Borne Animal Diseases
- Cholinesterase and Neurodegenerative Diseases
- IL-33, ST2, and ILC Pathways
- Vitamin D Research Studies
- Circular RNAs in diseases
- Alzheimer's disease research and treatments
- Inflammasome and immune disorders
- Mosquito-borne diseases and control
- Parasitic Diseases Research and Treatment
- MXene and MAX Phase Materials
- MicroRNA in disease regulation
- Insect Utilization and Effects
- Genomics, phytochemicals, and oxidative stress
- Opioid Use Disorder Treatment
- Streptococcal Infections and Treatments
University of Zurich
2016-2025
ZHAW Zurich University of Applied Sciences
2023-2025
Australian Institute of Tropical Health and Medicine
2017-2022
James Cook University
2017-2022
University of Basel
2019-2021
Medizinische Akademie Erfurt
1989
ABSTRACT The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions extracellular vesicles (EVs), collective term covering various subtypes cell‐released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, many other names. However, specific issues arise when working with these entities, whose size amount often make them difficult to obtain as relatively...
Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal harm their hosts, allowing them establish chronic infections. This is mediated by creating an immunoregulatory environment. Indeed, are such potent suppressors of inflammation that they been used clinical trials treat inflammatory bowel diseases (IBD) and celiac disease. Since the recent description helminths (worms) secreting extracellular vesicles (EVs), exosome-like EVs from different characterized...
ABSTRACT Whipworms are parasitic nematodes that live in the gut of more than 500 million people worldwide. Owing to difficulty obtaining parasite material, mouse whipworm Trichuris muris has been extensively used as a model study human infections. These secrete multitude compounds interact with host tissues where they orchestrate existence. Herein we provide first comprehensive characterization excretory/secretory products T. . We identify 148 proteins secreted by and show for time secretes...
The protozoan Eimeria tenella is a common parasite of chickens, causing avian coccidiosis, disease on-going concern to agricultural industries. high prevalence E. can be attributed the resilient oocyst stage, which transmitted between hosts in environment. As related Coccidia, development eimerian appears dependent on completion parasite’s sexual cycle. RNA Seq transcriptome profiling offers insights into mechanisms governing biology stages (gametocytes) and potential identify targets for...
Over the last decade, research interest in defining how extracellular vesicles (EVs) shape cross-species communication has grown rapidly. Parasitic helminths, worm species found phyla Nematoda and Platyhelminthes, are well-recognised manipulators of host immune function physiology. Emerging evidence supports a role for helminth-derived EVs these processes highlights as an important participant cross-phylum communication. While mammalian EV field is guided by community-agreed framework...
Abstract Parasitic helminths infect over 1 billion people worldwide, while current treatments rely on a limited arsenal of drugs. To expedite drug discovery, we screened small-molecule library compounds with histories use in human clinical trials for anthelmintic activity against the soil nematode Caenorhabditis elegans . From this screen, found that neuromodulatory drugs sertraline, paroxetine, and chlorpromazine kill C. at multiple life stages including embryos, developing larvae gravid...
Background Canine babesiosis, caused by Babesia canis , is a prevalent and clinically relevant disease in Europe. Severe acute babesiosis characterized high mortality but prognosis not always correlated with clinical signs nor the level of parasitemia. Objective This study evaluated prognostic markers associated poor outcomes infections. Animals Methods We compared results routine laboratory profiles, hand‐held lactate glucose analyzer, phase response 2 groups naturally infected dogs (7...
Abstract Infections of dogs with virulent strains Babesia canis are characterized by rapid onset and high mortality, comparable to complicated human malaria. As in other apicomplexan parasites, most virulence factors responsible for survival pathogenicity secreted the host cell surface beyond where they remodel biochemically modify infected interacting proteins a very specific manner. Here, we investigated B . during acute infections report on silico predictions experimental analysis...
The ability of helminths to manipulate the immune system their hosts ensure own survival is often credited with affecting responses other pathogens. We undertook co-infection experiments in mice determine how infection intestinal helminth Heligmosomoides polygyrus affected parasitological, immunological and physiological outcomes a primary distinct species helminth; lung migratory parasite Nippostrongylus brasiliensis. found that migrating N. brasiliensis larvae were killed lungs H....
Abstract Background The human hookworm, Necator americanus, is a parasite that infects almost half billion people worldwide. Although treatment available, vaccination favorable to combat the spread of this due its wide distribution and continuous reinfection cycle in endemic communities. Methods We have designed lipopeptide oral delivery system using B-cell epitope derived from aspartic protease Na-APR-1 N attached T-helper epitope. Lipopeptides were self-assembled into nanoparticles or...
The human hookworm Necator americanus infects more than 400 million people worldwide, contributing substantially to the poverty in these regions. Adult stage N. live small intestine of host where they inject excretory/secretory (ES) products into mucosa. ES have been characterized at proteome level for a number animal species, but until now, difficulty obtaining sufficient has an obstacle characterizing secretome this important pathogen. Herein we describe and utilize information along with...
Aims Infections by the larval stage of tape worms Echinococcus multilocularis and granulosus s.l . are potentially fatal zoonoses affecting humans as dead‐end hosts. Histopathological evaluation hepatic echinococcosis is an integral part patient management, including distinction between alveolar (AE) cystic (CE), which associated with different disease courses treatments. To improve histopathological assessment lesions, we aimed to develop robust criteria evaluate their viability decay....
Background Schistosomiasis affects over 200 million people and there are concerns whether the current chemotherapeutic control strategy (periodic mass drug administration with praziquantel (PZQ)—the only licenced anti-schistosome compound) is sustainable, necessitating development of new drugs. Methodology/Principal findings We investigated efficacy polypyridylruthenium(II) complexes showed they were active against all intra-mammalian stages S. mansoni. Two compounds, Rubb12-tri Rubb7-tnl,...
Type 2 diabetes (T2D) is a major health problem and considered one of the top 10 diseases leading to death globally. T2D has been widely associated with systemic local inflammatory responses alterations in gut microbiota. Microorganisms, including parasitic worms microbes have exquisitely co-evolved their hosts establish an immunological interaction that essential for formation maintenance balanced immune system, suppression excessive inflammation. Herein we show both prophylactic...
Abstract Alternatively activated macrophages are essential effector cells during type 2 immunity and tissue repair following helminth infections. We previously showed that Ym1, an alternative activation marker, can drive innate IL-1R–dependent neutrophil recruitment infection with the lung-migrating nematode, Nippostrongylus brasiliensis, suggesting a potential role for inflammasome in IL-1–mediated response to infection. Although proteins such as NLRP3 have important proinflammatory...