A5059393922- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Parasite Biology and Host Interactions
- Extracellular vesicles in disease
- Parasites and Host Interactions
- MicroRNA in disease regulation
- Toxoplasma gondii Research Studies
- MXene and MAX Phase Materials
- Amoebic Infections and Treatments
- Helminth infection and control
- Coccidia and coccidiosis research
- Antifungal resistance and susceptibility
- Trypanosoma species research and implications
- Human-Animal Interaction Studies
- Circular RNAs in diseases
- Research on Leishmaniasis Studies
- Nematode management and characterization studies
- Viral Infections and Vectors
- Clostridium difficile and Clostridium perfringens research
- Dermatological diseases and infestations
- Galectins and Cancer Biology
- Medical and Biological Ozone Research
University of Buenos Aires
2015-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2024
Experimental Medicine and Biology Institute
2021
Administración Nacional de Laboratorios e Institutos de Salud
2006-2010
Fundación Ciencias Exactas y Naturales
2006
Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing inefficient drugs. Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium laboratory model Hymenolepis microstoma as examples. The 115- 141-megabase genomes offer insights into evolution parasitism. Synteny is maintained with distantly related blood flukes but find extreme losses genes pathways...
Over the last decade, research interest in defining how extracellular vesicles (EVs) shape cross-species communication has grown rapidly. Parasitic helminths, worm species found phyla Nematoda and Platyhelminthes, are well-recognised manipulators of host immune function physiology. Emerging evidence supports a role for helminth-derived EVs these processes highlights as an important participant cross-phylum communication. While mammalian EV field is guided by community-agreed framework...
Echinococcus granulosus is characterized by high intra-specific variability (genotypes G1–G10) and according to the new molecular phylogeny of genus Echinococcus, E. complex has been divided into sensu stricto (G1–G3), equinus (G4), ortleppi (G5), canadensis (G6–G10). The characterization isolates fundamental understand spatio-temporal epidemiology this in many endemic areas with simultaneous occurrence different species genotypes. To simplify genotyping we developed a single-tube multiplex...
Abstract Galectin-1 (Gal-1), an endogenous glycan-binding protein, is widely distributed at sites of inflammation and microbial invasion. Despite considerable progress regarding the immunoregulatory activity this lectin, role Gal-1 during acute parasite infections uncertain. In study, we show that functions as a negative regulator to limit host-protective immunity following intradermal infection with Trypanosoma cruzi. Concomitant upregulation immune inhibitory mediators, including IL-10,...
microRNAs (miRNAs), a class of small non-coding RNAs, are key regulators gene expression at post-transcriptional level and play essential roles in fundamental biological processes such as development metabolism. The particular developmental metabolic characteristics cestode parasites highlight the importance studying miRNA regulation these organisms. Here, we perform comprehensive analysis miRNAs parasitic Echinococcus canadensis G7, one causative agents neglected zoonotic disease cystic...
The parasite Echinococcus canadensis (G7) (phylum Platyhelminthes, class Cestoda) is one of the causative agents echinococcosis. Echinococcosis a worldwide chronic zoonosis affecting humans as well domestic and wild mammals, which has been reported prioritized neglected disease by World Health Organisation. No genomic data, comparative analyses or efficient therapeutic diagnostic tools are available for this severe disease. information presented in study will help to understand peculiar...
Echinococcosis represents a major public health problem worldwide and is considered neglected disease by the World Health Organization. The etiological agents are Echinococcus tapeworms, which display elaborate developmental traits that imply complex control of gene expression. MicroRNAs (miRNAs), class small regulatory RNAs, involved in regulation many biological processes such as development metabolism. They act through repression messenger RNAs (mRNAs) usually binding to 3' untranslated...
Extracellular vesicles (EVs) include a heterogeneous group of particles. Microvesicles, apoptotic bodies and exosomes are the most characterized vesicles. They can be distinguished by their size, morphology, origin molecular composition. To date, increasing studies demonstrate that EVs mediate intercellular communication. reach considerable interest in scientific community due to role diverse processes including antigen-presentation, stimulation anti-tumoral immune responses, tolerogenic or...
Filamentous fungi, in particular the species Aspergillus, Scedosporium and Exophiala, frequently colonize lungs of cystic fibrosis (CF) patients. Chronic colonization is linked to hypersensitivity reactions persistent infections leading a significant long-term decline lung function. Azole antifungal therapy such as voriconazole (VRC) slows disease progression, patients with advanced CF; however, excessive mucus production CF poses diffusional barrier effective treatment. Here, biodegradable...
Background/Objectives: Filamentous fungi, in particular the species Aspergillus, Scedosporium, and Exophiala, frequently colonize lungs of cystic fibrosis (CF) patients. Chronic colonization is linked to hypersensitivity reactions persistent infections leading a significant long-term decline lung function. Azole antifungal therapy such as voriconazole (VRC) slows disease progression, particularly patients with advanced CF; however, excessive mucus production CF poses diffusional barrier...
The larva of cestodes belonging to the Echinococcus granulosus sensu lato (s.l.) complex causes cystic echinococcosis (CE). It is a globally distributed zoonosis with significant economic and public health impact. most immunogenic specific Echinococcus-genus antigen for human CE diagnosis B (AgB), an abundant lipoprotein hydatid cyst fluid (HF). AgB protein moiety (apolipoprotein) encoded by five genes (AgB1-AgB5), which generate mature 8 kDa proteins (AgB8/1-AgB8/5). These seem be...
Extracellular RNAs (ex-RNAs) are secreted by cells through different means that may involve association with proteins, lipoproteins or extracellular vesicles (EV). In the context of parasitism, ex-RNAs represent new and exciting communication intermediaries promising potential as novel biomarkers. last years, it was shown helminth parasites secrete ex-RNAs, however, most work mainly focused on RNA secretion mediated EV. Ex-RNA study is special interest in those infections still lack...