A5087983015- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- HIV Research and Treatment
- Plant pathogens and resistance mechanisms
- Advanced biosensing and bioanalysis techniques
- Parasitic Infections and Diagnostics
- Parasitic infections in humans and animals
- Genomics and Phylogenetic Studies
- Parasitic Diseases Research and Treatment
- Protist diversity and phylogeny
- CRISPR and Genetic Engineering
- Bacteriophages and microbial interactions
- Plant Disease Management Techniques
- Plant and animal studies
- Plant Parasitism and Resistance
- Biological Research and Disease Studies
- Research on Leishmaniasis Studies
- Helminth infection and control
- Evolution and Genetic Dynamics
- Virology and Viral Diseases
- Hepatitis Viruses Studies and Epidemiology
- Agricultural pest management studies
- Trace Elements in Health
- Plant Virus Research Studies
- Yeasts and Rust Fungi Studies
Wellcome Sanger Institute
2013-2024
Genomics (United Kingdom)
2024
Base4 Innovation (United Kingdom)
2020
Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing inefficient drugs. Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium laboratory model Hymenolepis microstoma as examples. The 115- 141-megabase genomes offer insights into evolution parasitism. Synteny is maintained with distantly related blood flukes but find extreme losses genes pathways...
Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans animals, decimate crop production are a major impediment to socioeconomic development. Here we report broad comparative study 81 genomes parasitic non-parasitic worms. We have identified gene family births hundreds expanded families at key nodes in the phylogeny that relevant parasitism. Examples include modulate host immune responses, enable parasite migration though tissues or...
Whipworms are common soil-transmitted helminths that cause debilitating chronic infections in man. These nematodes only distantly related to Caenorhabditis elegans and have evolved occupy an unusual niche, tunneling through epithelial cells of the large intestine. We report here whole-genome sequences human-infective Trichuris trichiura mouse laboratory model muris. On basis whole-transcriptome analyses, we identify many genes expressed a sex- or life stage-specific manner characterize...
Abstract Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents first application population genomics to S. based on high-coverage resequencing data from 10 global isolates and an isolate closely-related rodhaini , which rodents. Using genetic tests, we document genes under directional balancing selection may facilitate adaptation human host. Coalescence modeling reveals speciation as 107.5–147.6KYA, period overlaps with earliest...
The lethal zoonosis alveolar echinococcosis is caused by tumour-like growth of the metacestode stage tapeworm Echinococcus multilocularis within host organs. We previously demonstrated that proliferation exclusively driven somatic stem cells (germinative cells), which are only mitotically active parasite give rise to all differentiated cell types. gene repertoire required for germinative maintenance and differentiation has not been characterised so far. herein carried out Illumina sequencing...
Background Guinea worm– Dracunculus medinensis– was historically one of the major parasites humans and has been known since antiquity. Now, worm is on brink eradication, as efforts to interrupt transmission have reduced annual burden disease from millions infections per year in 1980s only 54 human cases reported globally 2019. Despite enormous success eradication date, complication arisen. Over last few years, hundreds dogs found infected with this previously apparently anthroponotic...
Schistosomiasis is the most important helminthic disease of humanity in terms morbidity and mortality. Facile manipulation schistosomes using lentiviruses would enable advances functional genomics these related neglected tropical diseases pathogens including tapeworms, their non-dividing cells. Such approaches have hitherto been unavailable. Blood stream forms human blood fluke, Schistosoma mansoni, causative agent hepatointestinal schistosomiasis, were infected with HIV-1 isolate NL4-3...
Advances in both high-throughput sequencing and whole-genome amplification (WGA) protocols have allowed genomes to be sequenced from femtograms of DNA, for example individual cells or precious clinical archived samples. Using the highly curated Caenorhabditis elegans genome as a reference, we identified errors biases associated with Illumina library construction, insert size, different WGA methods features such GC bias simple repeat content. Detailed analysis reads amplified libraries...
Despite remarkable progress in DNA sequencing technologies there remains a trade-off between short-read platforms, having limited ability to sequence homopolymers, repeated motifs or long-range structural variation, and long-read which tend have lower accuracy and/or throughput. Moreover, current methods do not allow direct readout of epigenetic modifications from single read. With the aim addressing these limitations, we developed an optical electrowetting platform that uses step-wise...
Abstract Background Guinea worm – Dracunculus medinensis was historically one of the major parasites humans and has been known since antiquity. Now, is on brink eradication, as efforts to interrupt transmission have reduced annual burden disease from millions infections per year in 1980s only 30 human cases reported globally last year. Despite enormous success eradication date, complication arisen. Over few years, hundreds dogs found infected with this previously apparently anthroponotic...