Simona Fica
A5042340054- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Thyroid Disorders and Treatments
- Diabetes and associated disorders
- Growth Hormone and Insulin-like Growth Factors
- Neuroblastoma Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Bone health and osteoporosis research
- Diabetes Management and Research
- Ovarian function and disorders
- Bone health and treatments
- Bariatric Surgery and Outcomes
- Parathyroid Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Lung Cancer Research Studies
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- Sexual Differentiation and Disorders
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hormonal and reproductive studies
- Hemoglobinopathies and Related Disorders
Carol Davila University of Medicine and Pharmacy
2016-2025
Clinical Emergency Hospital Bucharest
2016-2025
University of Colombo
2025
Instituto de Salud Carlos III
2023
Hospital Universitari Germans Trias i Pujol
2023
Centre for Biomedical Network Research on Rare Diseases
2023
Emergency University
2016-2021
Sahlgrenska University Hospital
2019
University of Gothenburg
2019
Centre Norbert Elias
2016
Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete penetrance. Clinical screening of apparently unaffected AIP mutation (AIPmut) carriers could identify previously unrecognized disease. To determine the mutational status FIPA and young patients, analyzing their clinical characteristics, perform AIPmut carrier family members. This was observational, longitudinal study conducted...
Abstract Background 46,XY gonadal dysgenesis is classified as complete (CGD) or partial (PGD) subtypes. The phenotype of PGD and the long-term outcome not clearly defined. Objective To evaluate clinical features pubertal in a large cohort, using CGD comparator for diagnostic clarity. Methods Patients with GD were identified from I-DSD Registry data on phenotype, genetics, biochemistry, histology development collated three categories; (n=100), assigned female (PGDf, n=107) male (PGDm, n=103)...
Patients with Cushing's syndrome (CS) have increased mortality. The aim of this study was to evaluate the causes and time death in a large cohort patients CS establish factors associated mortality.In study, we analyzed 1564 included European Registry on (ERCUSYN); 1045 (67%) had pituitary-dependent CS, 385 (25%) adrenal-dependent 89 (5%) an ectopic source 45 (3%) other causes. median (IQR) overall follow-up ERCUSYN 2.7 (1.2-5.5) years.Forty-nine died at analysis; 23 (47%) 6 (12%) 18 (37%)...
Abstract Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting to clinical characteristics AIPmut AIPneg patients. Design 12-year prospective, observational study. Participants & Setting We studied probands...
Abstract Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies patients with Cushing's syndrome (CS) included the European Registry on Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent (ADR-CS), 107 (6%) an ectopic source (ECT-CS). According to WHO criteria, 1616 (90.2%) were classified as younger (<65...
<b><i>Aim: </i></b>High-quality national representative data on obesity in Romanian children are needed to shape public health policies. To provide<b> </b>a unified landscape prevalence, trends and other factors associated with underweight, overweight, aged 6-19 years, across the last decade (2006-2015). <b><i>Methods:</i></b> Using a common protocol, we selected published unpublished studies that measured schools between 2006 2015....
Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical (PMT) affects postoperative outcome remains controversial.(1) Evaluate how frequently PMT given to CS patients across Europe; (2) examine differences in characteristics who receive and those undergo primary surgery (3) determine if influences pituitary-dependent (PIT-CS).1143 entered into ERCUSYN database from 57 centers 26 countries....
Abstract Objective The aim of this study was to evaluate the prevalence venous thromboembolism (VTE) in patients included European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. Design A retrospective observational cohort study. Methods Data extraction from registry taken February, 7, 2022. At time there were 2174 diagnosed (CS) 95 VTEs reported database. Results Of events 70 (74%)...
Epidemiological data on obesity prevalence are scarce in Romanian population. Consequently, the aim of our study was to evaluate and unhealthy behaviors among school children adolescents from Bucharest, Romania.Cross-sectional study, 866 participants (53.2% girls, 46.8% boys, age range 6-18 years), selected by systematic sampling with probability-proportionate-to-size all Bucharest's schools.height, weight a questionnaire collect information about life style eating behavior. Nutritional...
Introduction: The current study aimed to assess recent acute myocardial infarction (AMI) mortality rates and trends in Romania between 1994 2017. This dataset is a necessity the context of improvement emergency protocols, medical addressability, modernization hospital infrastructure. Materials Methods: retrospective analysis an anonymized database containing all deaths registered during 1994–2017. AMI crude (CMR) age-standardized (ASMR) were calculated using European Standard Population....
Introduction: Cardiovascular disease is the commonest cause of death in Turner syndrome (TS) for which, arterial hypertension has a direct influence and key modifiable risk factor. Objective: To investigate prevalence patterns diagnosis management adult patients with TS who are registered large international multicentre database (TS-HTN study). Methods: Retrospective multi-centre observational study aged ≥18 years, included I-TS (International-TS) registry (2020-2022) utilising participating...
Abstract Objective Heterozygous germline loss-of-function variants in AIP are associated with young-onset growth hormone and/or prolactin-secreting pituitary tumours. However, the pathogenic role of c.911G&gt;A; p.(Arg304Gln) (R304Q) variant has been controversial. Recent data from public exome/genome databases show this is not infrequent. The objective work was to reassess pathogenicity R304Q based on clinical, genomic and functional assay data. Design, materials methods Data were...
Objective: Our understanding of the pathophysiology pancreatic neuroendocrine tumors (PanNETs) remains incomplete, largely due to their historically underestimated incidence and perception these as rare slow-growing cancers. Additionally, conventional reliance on histological examination alone is gradually being supplemented by exploration introduction molecular biomarkers, such microRNAs (miRNAs). As miRNAs modulate expression multiple genes pathways involved in tumorigenesis PanNETs,...
Background: The primary endpoint was to assess the nutritional status in patients diagnosed with prostate cancer (PCa) Romania. secondary analyze impact of obesity on mortality and disease recurrence. Methods: In this retrospective cohort study, we analyzed files 354 PCa between August 2001 May 2022 referred Medical Oncology Department Neolife Center. A total 257 fulfilled inclusion criteria were subject study. Results: Excess weight seen 190 (73.9%) patients, 119 (46.3%) being overweight 71...
Background: The increasing incidence of autoimmune diseases in type 1 diabetes mellitus (T1DM) patients highlights the influence human leukocyte antigen (HLA) haplotypes on their development. This study aims to determine genetic predisposition T1DM patients, including thyroid disease and celiac diseases, explore its correlation with vitamin D deficiency. Methods: A cross-sectional involving thirty-six children was conducted. Typing performed for HLA A, B, C, DP, DR, DQ loci. Regression...