A5090754703- Diabetes Treatment and Management
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Mobile Health and mHealth Applications
- Muscle metabolism and nutrition
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Education
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Chronic Kidney Disease and Diabetes
- Ovarian function and disorders
- Growth Hormone and Insulin-like Growth Factors
- Chronic Disease Management Strategies
- Gastric Cancer Management and Outcomes
- Renal Diseases and Glomerulopathies
- Telemedicine and Telehealth Implementation
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
Yeovil District Hospital NHS Foundation Trust
2011-2025
Yeovil District Hospital
2019-2025
Somerset Partnership NHS Foundation Trust
2020
Birmingham City Hospital
2019
Keele University
2019
Maastricht University
2008
Oxford Centre for Diabetes, Endocrinology and Metabolism
2005-2008
University of Oxford
2005-2008
Churchill Hospital
2005-2008
University of Birmingham
2008
Despite consistent evidence that abnormalities of fatty acid delivery and storage underlie the metabolic defects insulin resistance, physiological pathways by which fat is stored in adipose tissue skeletal muscle are not clear. We used a combination stable isotope labeling arteriovenous difference measurements to elucidate postprandial deposition healthy humans. A test meal containing [U-(13)C]palmitate was combined with intravenous infusion [(2)H(2)]palmitate label plasma acids...
Context: Low-grade inflammation in adipose tissue may contribute to insulin resistance obesity. However, the roles of individual inflammatory mediators are poorly understood. Objectives: The objective this study was determine which markers most overexpressed at gene level human obesity and how relates corresponding protein secretion. Design: We examined expression profiles 17 lean 20 obese subjects. secretory pattern relevant proteins sc or isolated fat cells vitro vivo several cohorts....
Pancreatic atrophy is common in longstanding type 1 diabetes, but there are limited data concerning pancreas size at diagnosis. Our objective was to determine whether pancreatic reduced patients with recently diagnosed diabetes and assess volume related residual β-cell function or islet autoantibodies. We conducted a controlled cohort study strict inclusion criteria, recruiting from hospital clinics between 2007 2010. Participants included 20 male adult (median age 27 yr) recent-onset...
Abstract Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting to clinical characteristics AIPmut AIPneg patients. Design 12-year prospective, observational study. Participants & Setting We studied probands...
Studies have suggested that polycystic ovary syndrome (PCOS) is associated with increased cardiovascular risk. The aim of this study was to examine risk profiles in women PCOS compared healthy age and weight matched control subjects using novel biochemical biophysical markers.After ethics committee approval, 11 12 controls were recruited (mean age, 32; SD, 6.5 years; mean body mass index (BMI), 33.1; 5.9 kg/m2). Serum analysed for lipid lipoprotein profile (total high density cholesterol,...
OBJECTIVE—We aimed to determine differences in the postprandial contributions of different fatty acid sources VLDL triglycerides (TGs) healthy men and women with varying degrees insulin resistance. RESEARCH DESIGN AND METHODS—Insulin-resistant (n = 11) insulin-sensitive 6) were given an intravenous infusion [2H2]palmitic investigate systemic nonesterified (NEFA) incorporation into TGs. Participants also fed a mixed meal containing [U-13C]palmitic contribution dietary acids TG production....
The MyWay Diabetes (MWD) digital platform aims to improve diabetes management through personalised access health records, structured education, and other self-management features. We aimed assess outcomes in MWD users with type 1 (T1DM) 2 (T2DM) over 6 years of use. An interrupted time-series analysis T1DM or T2DM Somerset, UK, compared pre- post-MWD registration trends estimate differences (HbA1c, blood pressure, lipids, BMI, weight). Generalised estimating equations modelling adjusted for...
Objective: To evaluate longitudinal real-world outcomes in adults with type 1 diabetes initiating hybrid closed loop (HCL). Methods: Adults diabetes, managed an insulin pump and intermittently scanned continuous glucose monitoring hemoglobin A1c (HbA1c) ≥8.5% (69 mmol/mol), were started on HCL between August December 2021 as part of the National Health Service England pilot. We collected outcomes, including change HbA1c, sensor glucometrics, Gold score (hypoglycemia awareness), distress...
Type 2 diabetes self-management education is an essential component of type care that traditionally delivered in a face-to-face setting. In response to the recent COVID-19 pandemic, innovative solutions are urgently needed, allowing provision can be compliance with social distancing policies. Innovations self-service and deliver efficiently at low cost particularly appealing healthcare providers commissioners.We aimed evaluate user uptake, dropout, acceptability, satisfaction, perceived...
Ramadan-focused diabetes education is critical to facilitate safer Ramadan fasting amongst Muslim people living with diabetes. We present the design, delivery, and evaluation of two parallel massive open online courses (MOOCs) in for HCPs.
Dr Marie-France Kong Consultant Physician, University Hospitals of Leicester NHS Trust, UK Type 2 diabetes mellitus is a progressive disease characterised by continued gradual decrease in pancreatic beta-cell function, impaired insulin secretion, and increasingly severe deficiency resulting loss glycaemic control over time, most patients will ultimately require therapy.1,2 Insulin secretion ∼50% diminished at the time diagnosis type continues to decline, least those treated with diet,...
Colonic resection leads to insulin resistance, but the mechanisms are unknown. We used an integrated approach examine adipose tissue and skeletal muscle metabolism in patients lacking a colon. Ten healthy colectomized having undergone surgery for ulcerative colitis 10 matched control subjects were studied with hyperinsulinemic-euglycemic clamp measure sensitivity, arteriovenous sampling meal tolerance study postprandial substrate flux across muscle, biopsies quantify expression of genes...
Introduction: Evidence from phase III and the EMPA-REG OUTCOME trials have demonstrated improvements in renal endpoints with empagliflozin use. The EMPA-KIDNEY trial is currently underway assessing whether there are benefits of improving outcomes people both without diabetes, mechanism has been suggested to be similar that ACE inhibitors haemodynamic effects sodium-glucose co-transporter-2 inhibition reducing intraglomerular pressure.Aim: To assess impacts use on albuminuria estimated...
Abstract ACE inhibitors are recognised as playing an increasingly pivotal role in the prevention and treatment of diabetic complications, although prescribing remains controversial. The aim this study was to assess current practice for patients with type 1 or 2 diabetes. A simple postal questionnaire devised examine habits diabetes sent all diabetologists England, Wales Northern Ireland. response rate 57% (220/389 replies). Significant differences between inhibitor were observed hypertension...
Urea kinetics were measured non-invasively in 12 Chilean schoolboys aged 8-10 years who receiving one of two diets, either predominantly animal protein or vegetable protein. Both the diets provided an equivalent level gross protein, 1.2 g/kg/day. The study given for 10 days to enable adaptation take place. On eighth day a single oral dose 15N15N-urea, 100 mg, was and amount label excreted as 15N15-urea urine over subsequent 48 hours measured. There little difference any aspect urea between...