David Carty
A5065579780- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Diabetes Management and Research
- Adrenal and Paraganglionic Tumors
- Gestational Diabetes Research and Management
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Neuroblastoma Research and Treatments
- Cardiovascular Health and Disease Prevention
- Diabetes and associated disorders
- Advanced Proteomics Techniques and Applications
- Hormonal Regulation and Hypertension
- Atherosclerosis and Cardiovascular Diseases
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Treatment and Management
- Thyroid Cancer Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatitis Pathology and Treatment
- Neonatal Respiratory Health Research
- Cancer, Hypoxia, and Metabolism
- IgG4-Related and Inflammatory Diseases
Glasgow Royal Infirmary
2013-2024
University of Glasgow
2013-2024
University of Edinburgh
2022
Sir Charles Gairdner Hospital
2020
Erasmus MC
2020
Biogipuzkoa Health Research Institute
2020
Queen Mary University of London
2020
William Harvey Research Institute
2020
Birmingham City Hospital
2019
Royal Berkshire Hospital
2019
Pregnant women with type 1 diabetes are a high-risk population who recommended to strive for optimal glucose control, but neonatal outcomes attributed maternal hyperglycaemia remain suboptimal. Our aim was examine the effectiveness of continuous monitoring (CGM) on control and obstetric health outcomes.In this multicentre, open-label, randomised controlled trial, we recruited aged 18-40 years minimum 12 months were receiving intensive insulin therapy. Participants pregnant (≤13 weeks 6 days'...
Preeclampsia is a major determinant of fetal and maternal morbidity mortality. We used proteomic strategy to identify urinary biomarkers that predict preeclampsia before the onset disease. prospectively collected urine samples from women throughout pregnancy. Samples gestational weeks 12 16 (n=45), 20 (n=50), 28 (n=18) who subsequently had develop were matched controls (n=86, n=49, n=17, respectively). performed capillary electrophoresis online coupled micro-time-of-flight mass spectrometry....
OBJECTIVE To compare glycemic control, quality of life, and pregnancy outcomes women using insulin pumps multiple daily injection therapy (MDI) during the Continuous Glucose Monitoring in Women With Type 1 Diabetes Pregnancy Trial (CONCEPTT). RESEARCH DESIGN AND METHODS This was a prespecified analysis CONCEPTT involving 248 pregnant from 31 centers. Randomization stratified for pump versus MDI HbA1c. The primary outcome change HbA1c randomization to 34 weeks’ gestation. Key secondary were...
OBJECTIVE To determine if temporal glucose profiles differed between 1) women who were randomized to real-time continuous monitoring (RT-CGM) or self-monitored blood (SMBG), 2) used insulin pumps multiple daily injections (MDIs), and 3) whose infants born large for gestational age (LGA) not, by assessing CGM data obtained from the Continuous Glucose Monitoring in Women With Type 1 Diabetes Pregnancy Trial (CONCEPTT). RESEARCH DESIGN AND METHODS Standard summary metrics functional analysis...
Abstract Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting to clinical characteristics AIPmut AIPneg patients. Design 12-year prospective, observational study. Participants & Setting We studied probands...
The CONCEPTT trial compared real-time Continuous Glucose Monitoring (RT-CGM) to capillary glucose monitoring in pregnant women with type 1 diabetes. We analyzed CGM and glycated hemoglobin (HbA1c) measures first (n = 221), second 197), third 172) trimesters, aiming examine target attainment associations pregnancy outcomes. targets were Time-in-range (TIR) > 70%, Time-above-range (TAR) <25%, Time-below-range (TBR) < 4%, HbA1c 6.5% (National Institute for Health Care Excellence [NICE]) 6.0%...
Pregnant women with type 1 diabetes strive for tight glucose targets (3.5-7.8 mmol/L) to minimise the risks of obstetric and neonatal complications. Despite using technologies including continuous monitoring (CGM), insulin pumps contemporary analogues, most struggle achieve maintain recommended pregnancy targets. This study aims evaluate whether use automated closed-loop delivery improves antenatal levels in pregnant diabetes.A multicentre, open label, randomized, controlled trial a HbA1c...
Preeclampsia is a multisystem disease that significantly contributes to maternal and foetal morbidity mortality. In this study, we used nonbiased microarray approach identify novel circulating miRNAs in plasma may be associated with preeclampsia.Plasma samples were obtained at 16 28 weeks of gestation from 18 women who later developed preeclampsia (cases) matched normotensive pregnancies (controls). We studied miRNA expression profiles subsequently confirmed target gene placenta samples....
Circulating biomarkers of endothelial dysfunction and inflammation are elevated in late pregnancy women with preeclampsia. We examined plasma levels inflammatory cytokines adhesion molecules early pregnancy, to assess their ability predict preeclampsia.In a prospective longitudinal study, 2600 singleton pregnancies no history hypertension were recruited at antenatal hospital (booking) visit gestational week 12-16. Of these, 49 (1.9%) developed preeclampsia, whereas 74 matched for age BMI...
We have previously described a panel of 238 urinary polypeptides specific for established severe coronary artery disease (CAD). Here we studied this polypeptide in patients with wider range CAD severity. recruited 60 who underwent elective angiography investigation stable angina. Patients were selected either having angiographic evidence or not (NCA) following (n = 30/30; age, 55 ± 6 vs. 56 7 years, P 0.539) to cover the extremes spectrum. A further 66 (age, 64 9 years) prior surgical...
Endothelial dysfunction is known to play a key role in the pathogenesis of preeclampsia, but majority methods for its detection are too invasive be used pregnancy. In this study we report novel method - peripheral arterial tonometry (PAT) examining microcirculatory function pregnancy.One hundred and eighty women with at least two risk factors preeclampsia were examined gestational weeks 16 28; 80 6-9 months postnatally. Twenty-four developed or pregnancy-induced hypertension (cases), 156...
Summary Background Patients with fractures should be prioritized for assessment osteoporosis so that they can benefit from treatment the secondary prevention of osteoporotic fractures. Assessment is seldom offered to patients vertebral because these are typically not diagnosed. Vertebral identified by fracture (VFA) using current dual‐energy X‐ray absorptiometry (DXA) scanners. Objective The purpose this study was assess prevalence fractures, VFA, in presenting nonvertebral and whether...