A5112787716- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cytokine Signaling Pathways and Interactions
- Cardiac electrophysiology and arrhythmias
- Cardiac and Coronary Surgery Techniques
- MicroRNA in disease regulation
- Infective Endocarditis Diagnosis and Management
- Circular RNAs in diseases
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac tumors and thrombi
- Pericarditis and Cardiac Tamponade
- Cardiomyopathy and Myosin Studies
- Immune cells in cancer
- Heart Failure Treatment and Management
Carol Davila University of Medicine and Pharmacy
2015-2025
Clinical Emergency Hospital Bucharest
2015-2025
William Osler Health System
2023-2024
Ecolab (United Kingdom)
2017-2021
Administraţia Naţională de Meteorologie
2019
University of Toronto
2010-2019
University Health Network
2010-2016
Princess Margaret Cancer Centre
2011-2016
Ontario Institute for Cancer Research
2013
University of Craiova
2007
Small non-coding microRNAs (miRNAs) are implicated in gene regulation, including those involved coronary artery disease (CAD). Our aim was to identify whether specific serum miRNAs present the circulating lipoproteins (Lp) associated with stable or vulnerable CAD patients. A cardiovascular disease-focused screening array used assess distribution sera collected from 95 patients: 30 angina (SA), 39 unstable (UA), 26 at one month after myocardial infarction (MI) and 16 healthy control subjects....
We have previously described interstitial Cajal-like cells (ICLC) in human atrial myocardium. Several complementary approaches were used to verify the existence of ICLC interstitium rat or ventricular myocardium: primary cell cultures, vital stainings (e.g.: methylene blue), traditional (including silver impregnation), phase contrast and non-conventional light microscopy (Epon-embedded semithin sections), transmission electron (TEM) (serial ultrathin stereology, immunohistochemistry (IHC)...
Abstract There is a stringent need to find means for risk stratification of coronary artery diseases (CAD) patients. We aimed at identifying alterations plasma high-density lipoproteins (HDL) components and their validation as dysfunctional HDL that could discriminate between acute syndrome (ACS) stable angina (SA) 2 3 were isolated from CAD patients’ healthy subjects. ApolipoproteinAI (apoAI), apoAII, apoCIII, malondialdehyde (MDA), myeloperoxidase (MPO), ceruloplasmin paraoxonase1 (PON1)...
We aimed to determine the levels of microRNAs (miRNAs) in sera and HDL acute coronary syndrome (ACS) compared stable angina (SA) patients with/without hyperglycemia, evaluate comparatively functional effect these on processing machinery proteins (Drosha, DGCR8, Dicer) miRNAs production human macrophages. MiRNAs from 35 SA 72 ACS 30 healthy subjects were measured by using microRNA TaqMan assays. MiR-223, miR-92a, miR-486, miR-122, miR-125a miR-146a higher hyperglycemic normoglycemic sera....
Introduction: The current study aimed to assess recent acute myocardial infarction (AMI) mortality rates and trends in Romania between 1994 2017. This dataset is a necessity the context of improvement emergency protocols, medical addressability, modernization hospital infrastructure. Materials Methods: retrospective analysis an anonymized database containing all deaths registered during 1994–2017. AMI crude (CMR) age-standardized (ASMR) were calculated using European Standard Population....
Abstract Rett syndrome is a pediatric neurological condition that affects primarily girls. Approximately 30% of cases arise from point mutations introduce premature stop codon into the MECP2 gene. Several studies have now shown certain aminoglycosides can facilitate read‐through some types nonsense in context‐dependent manner and allow generation full‐length protein. It remains mostly unclear whether different will be responsive to aminoglycoside treatment. In this study, we tested common...
Left atrial (LA) size is an important predictor of outcome after mitral valve replacement in patients with symptomatic chronic regurgitation (MR). Data on LA remodelling repair (MVr) for non-ischaemic MR are scarce. The aim this study was to assess changes early MVr severe degenerative and identify clinical echocardiographic correlates those changes.The analysed 225 consecutive who underwent were echocardiographically evaluated our hospital within 1 month before 1-6 months surgery. Patients...
Abstract Many promising new cancer drugs proceed through preclinical testing and early-phase trials only to fail in late-stage clinical testing. Thus, improved models that better predict survival outcomes enable the development of biomarkers are needed identify patients most likely respond benefit from therapy. Here, we describe a comprehensive approach which incorporated biobanking, xenografting, multiplexed phospho-flow (PF) cytometric profiling study drug response predictive acute myeloid...
Background: Left atrial (LA) volume and B‐type natriuretic peptide (BNP) represent powerful outcome predictors in patients with heart failure (HF). Aim: To assess the comparative prognostic role of LA (indexed to body surface area, LAVi), left ventricular diastolic dysfunction (LVDD) BNP levels on long‐term symptomatic but stable chronic HF. Methods: We studied consecutively 46 HF (73 ± 10 years, 30 men), sinus rhythm, without significant valvular disease. Echocardiographic measurements...
The left ventricular (LV) response to combined pressure and volume overload [aortic stenosis (AS) aortic regurgitation (AR)] versus (isolated AS)has not been systematically studied. We aimed assess LV remodeling, functional hemodynamic consequences inpatients with mixed valve disease patients isolated AS.We enrolled 181 (67 ± 9 years,109 men) severe AS (aortic area indexed body surface <0.6 cm 2 /m ) who underwent preoperative cardiac catheterization a complete echocardiogram. Pulmonary...
Background In severe aortic stenosis, different left ventricle ( LV ) remodeling patterns as a response to pressure overload have distinct hemodynamic profiles, cardiac function, and outcomes. The most common classification considers relative wall thickness mass index create 4 groups. A new including also end‐diastolic volume has been recently proposed. Aim To describe the prevalence of newly identified in patients with stenosis evaluate their clinical relevance according symptoms. Methods...
Emergency Department (ED) boarding crowds the emergency department, strains resources, leads to higher hospital costs, and is associated with increased morbidity/mortality, a negative patient experience, adverse events. The time Ontario patients wait in departments for inpatient beds continues rise, average admitted spend ED increasing between 2015 2019 from 13.8 hours 16.2 hours. As reported this quality improvement initiative, one potential solution repurpose short-stay medical assessment...
Drought directly and indirectly affects human society in a number of ways.In many regions the world climate change will exasperate effects droughts, affect national economies more intensely.The main aim this article was to catalogue analyze drought impacts 11 Central South Eastern European states located Danube river basin.The identification dry episodes based on information from publicly available sources, namely, newspaper journal articles that reported impacts.Information impact...