A5041765554- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Extraction and Separation Processes
- Urticaria and Related Conditions
- Dermatologic Treatments and Research
- Oral Health Pathology and Treatment
- Cutaneous lymphoproliferative disorders research
- Radioactive element chemistry and processing
- Nail Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Asthma and respiratory diseases
- Autoimmune and Inflammatory Disorders Research
- Skin Protection and Aging
- Autoimmune and Inflammatory Disorders
- Adsorption and biosorption for pollutant removal
- melanin and skin pigmentation
- Cutaneous Melanoma Detection and Management
- Acne and Rosacea Treatments and Effects
- Drug-Induced Adverse Reactions
- Vascular Tumors and Angiosarcomas
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Wound Healing and Treatments
- Anesthesia and Sedative Agents
- Antifungal resistance and susceptibility
Universidad de Los Andes, Chile
2022-2025
University of Chile
2016-2025
Probity Medical Research
2015-2025
Hospital Clínico de la Universidad de Chile
2011-2024
Centro de Estudios Científicos
2018-2024
Clínica Las Condes
2018-2021
ORCID
2020
Hospital Universitario Fundación Jiménez Díaz
2014
Instituto de Ciências Farmacêuticas
2014
Clínica Dávila
2011
Psoriasis severity categories have been important tools for clinicians to use in treatment decisions as well determine eligibility criteria clinical studies. However, owing the heterogeneity of classifications and their lack consideration impact psoriasis involvement special areas or past history, patients may be miscategorized, which can lead undertreatment psoriasis.To develop a consensus statement on classification severity.A modified Delphi approach was developed by International Council...
Engaging global key opinion leaders, the International Psoriasis Council (IPC) held a day-long roundtable discussion with primary purpose to discuss treatment goals of psoriasis patients and worldwide barriers optimal care. Setting clear expectations might ultimately encourage undertreated seek care in an era which great gains therapeutic efficacy have been achieved. Here, we option for early all categories alleviate disease impact while emphasizing need more focused attention mild moderate...
Abstract Background Photoprotection is the first measure in prevention and treatment of deleterious effects that sunlight can cause on skin. It well known prolonged exposure to solar radiation leads acute chronic complications, such as erythema, accelerated skin aging, proinflammatory procarcinogenic effects, eye damage, among others. Methods A better understanding molecules protect against ultraviolet their will lead improvements health. Results Most these are modulated by oxidative stress...
Abstract Background Current treat‐to‐target recommendations for atopic dermatitis (AD) may not include high enough treatment targets and do fully consider patient needs. Objective To develop optimized AD management, including disease severity assessments, goals targets, guidance escalation/modification. Methods An international group of expert dermatologists drafted a series management using insights from global study 87 44 countries. Experts voted on modified eDelphi voting process. Results...
Abstract From our series of 72 patients with articular chondrocalcinosis, 37 who presented polyarticular involvement are described. Twenty‐eight patients, including 19 aggregated within different family groups, natives the Chiloé island group. Members 1 6 families had unusually severe disease deformities, and bony ankylosis multiple joints. Pathologic findings in both acute chronic stages joint presented, particularly, some changes that have not been described previously.
Nowadays, many major copper mining projects in desert areas with extremely dry climates, as northern Chile and the southern coast of Peru, process sulfide ores at high production rates; some cases over 100,000 metric tonnes per day (mtpd), generating large amounts tailings, that are commonly managed transported to tailings storage facilities (TSF) hydraulically using fresh water. Considering climate, water scarcity, community demands, environmental constraints these areas, efficient use is...
Quality of life impairment in dermatology patients and severity psoriasis are quantified by the Dermatology Life Index (DLQI) Psoriasis Area Severity (PASI), respectively. The aim this study is to compare correlation between PASI DLQI from different geographical areas identify predictors high across regions. Correlations were evaluated using Spearman’s rank tests quantile regression. included 1,158 with psoriasis, a median (interquartile range) 6.0 (3.0–12.0) 8.0 (4.0–15.0), demonstrated...
In this paper, we present a system that Compañía Sud Americana de Vapores (CSAV), one of the world's largest shipping companies, developed to support its decisions for repositioning and stocking empty containers. CSAV's main business is cargo in containers clients worldwide. It uses fleet about 700,000 TEU different types, which are carried by both CSAV-owned third-party ships. Managing container complex; CSAV must make thousands each day. particular, imbalances exist among regions. For...
Tofacitinib is an oral Janus kinase inhibitor. Final safety and efficacy data from open‐label extension study of tofacitinib in psoriasis are reported. To evaluate the long‐term durability adults with moderate‐to‐severe chronic plaque psoriasis. Eligible patients who completed qualifying phase II/III studies received 10 mg twice daily (q12h) until month 3; subsequently, dose could be adjusted by investigators to either 5 or q12h. Adverse events (AEs) reported up 66 laboratory 54. Efficacy...
Abstract Background Tofacitinib is an oral Janus kinase inhibitor that being investigated for psoriasis. Psoriasis impacts on physical and psychological well‐being; improvements in health‐related quality of life ( HRQ oL) with etanercept psoriasis are well documented. Objective To evaluate oL tofacitinib, vs. placebo or etanercept, the Phase 3, randomized, placebo‐controlled, non‐inferiority, Oral‐treatment Trial OPT ) Compare Study NCT 01241591). Methods Adults moderate to severe chronic...
Studies about chondrocalcinosis in the Chiloe Islands (Chile) showed high frequency of disease there and how most it is aggregated a few highly involved families. Pedigrees degree consanguinity among parents index cases pointed to recessive inheritance. The presence common Caucasian anthropological features genetic value patients lack Indian mixture three families, documented back 1600, suggest origin mutation. Biochemical studies patients' synovial fluid significant rise pyrophosphate...
In this work, an adsorbent was prepared based on the attachment of organophosphorus acid extractants, namely, D2EHPA, CYANEX 272, and 301, to surface superparamagnetic magnetite (Fe3O4) nanoparticles. The synthesized nanoparticles were coated with oleic acid, first by a chemisorption mechanism later respective extractant via physical adsorption. obtained core–shell functionalized nanoparticle composites characterized dynamic light scattering, scanning electron microscopy, transmission...
In recent years there has been a great demand for rare earth metals because of their unique physical and chemical properties as new constituents electronic, optical magnetic devices. Because oftheir extremely similar properties, it is very difficult to separate them. A study ofsolvent extraction oflighter lanthanide metal ions with family organophosphorus extractants, commercially known D2EPHA, PC88A, CYANEX 272 301, was made. general found that praseodymium were extracted all the while in...
It is studied the extraction of cadmium(II) ions from acidic aqueous solutions using a stirred transfer cell-type emulsion liquid membrane (ELM) prepared by dissolving in kerosene, with D2EHPA (an alkylphosphoric acid) as mobile carrier and Span-80 surfactant. The ELM allowed efficient metal transport feed solution to stripping liquor experiments carried out at 25 ºC. significant variables on cadmium through were extractant concentration content metal-donor solution. Concentration HCl agent...
Expert opinion: defining response to omalizumab in patients with chronic spontaneous urticariaOmalizumab (a recombinant, humanized anti-immunoglobulin-E antibody) has been shown three pivotal Phase III trials (ASTERIA I, II and GLACIAL) real-world studies be effective well-tolerated for the treatment of urticaria (CSU), is only licensed third-line CSU.However, definition often differs between clinical trials, studies, daily practice individual physicians globally.As such, a consensus...
Plaque psoriasis is a debilitating skin condition that affects approximately 2% of the adult population and for which there currently no cure. Tofacitinib an oral Janus kinase inhibitor being investigated psoriasis.The design this study has been reported previously (NCT00678210). Patients with moderate to severe chronic plaque received tofacitinib (2 mg, 5 or 15 mg) placebo, twice daily, 12 weeks. Lymphocyte sub-populations, cytomegalovirus (CMV) Epstein-Barr virus (EBV) DNA were measured at...