Francesca Capon
A5004704785- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- RNA Research and Splicing
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- COVID-19 and Mental Health
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders Research
- Pharmaceutical studies and practices
- RNA and protein synthesis mechanisms
- Dupuytren's Contracture and Treatments
- Nail Diseases and Treatments
- Biotin and Related Studies
- Immune Cell Function and Interaction
- bioluminescence and chemiluminescence research
King's College London
2016-2025
Guy's and St Thomas' NHS Foundation Trust
2020-2023
University of Chicago
2021
Guy's Hospital
2009-2018
Metropolitan University
2017
St Thomas' Hospital
2011
University College London
2006-2008
The King's College
2007
University of Leicester
2002-2005
University of Rome Tor Vergata
1994-2004
IL-23 and Th17 cells are key players in tissue immunosurveillance implicated human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease ankylosing spondylitis. We investigated immunological consequences of protective healthy donors. The had no major effect on cell differentiation as frequency circulating was similar carriers (A) common (G) allele. Accordingly, generated from A G donors produced...
The term pustular psoriasis indicates a group of severe skin disorders characterized by eruptions neutrophil-filled pustules. disease, which often manifests with concurrent vulgaris, can have an acute systemic (generalized [GPP]) or chronic localized (palmoplantar pustulosis [PPP] and acrodermatitis continua Hallopeau [ACH]) presentation. Although mutations been uncovered in IL36RN AP1S3, the rarity disease has hindered study genotype-phenotype correlations.We sought to characterize clinical...
Abstract Biologic therapies targeting the IL-23/IL-17 axis have transformed treatment of psoriasis. However, early mechanisms action these drugs remain poorly understood. Here, we perform longitudinal single-cell RNA-sequencing in affected individuals receiving IL-23 inhibitor therapy. By profiling skin at baseline, day 3 and 14 treatment, demonstrate that blockade causes marked gene expression shifts, with fibroblast myeloid populations displaying most extensive changes 3. We also identify...
Importance Generalized pustular psoriasis (GPP) lacks internationally accepted definitions and diagnostic criteria, impeding timely diagnosis treatment hindering cross-regional clinical epidemiological study comparisons. Objective To develop an international consensus definition criteria for GPP using the modified Delphi method. Evidence Review The rarity of presents a challenge in acquiring comprehensive published data necessary developing standardized criteria. Instead relying on...
Psoriasis is a chronic skin disorder with multifactorial aetiology. Genome-wide scans have provided unambiguous evidence for major disease susceptibility locus on chromosome 6p21 (PSORS1). A minimal PSORS1 interval has been defined which encompasses three genes (HLA-C, HCR and CDSN) carrying psoriasis-associated SNPs. On the basis of this genetic evidence, we undertaken an assessment CDSN allele functional impact. comparison intragenic haplotypes showed that SNPs exclusive to...
Psoriasis is an immune-mediated skin disorder that inherited as a multifactorial trait. Linkage studies have clearly identified primary disease susceptibility locus lying within the major histocompatibility complex (MHC), but generated conflicting results for other genomic regions. To overcome this difficulty, we carried out genome-wide association scan, where analyzed more than 408 000 SNPs in initial sample of 318 cases and 288 controls. Outside MHC, observed single cluster...
Prominent skin involvement is a defining characteristic of autoinflammatory disorders caused by abnormal IL-1 signaling. However, the pathways and cell types that drive cutaneous features remain poorly understood. We sought to address this issue investigating pathogenesis pustular psoriasis, model with predominant manifestations. specifically characterized impact mutations affecting AP1S3, disease gene previously identified our group validated here in newly ascertained patient resource....
Interleukin (IL)-36α, IL-36β, and IL-36γ are innate mediators of acute epithelial inflammation. We sought to demonstrate that these cytokines also required for the pathogenesis plaque psoriasis, a common chronic skin disorder, caused by abnormal T helper 17 (TH17) cell activation. To investigate this possibility, we first defined genes induced IL-36 in primary human keratinocytes. This enabled us significant signature among transcripts up-regulated psoriasis susceptibility loci associated...