A5002684132- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Veterinary Orthopedics and Neurology
- Acne and Rosacea Treatments and Effects
- Cutaneous lymphoproliferative disorders research
- Dermatologic Treatments and Research
- Hair Growth and Disorders
- Dermatological and Skeletal Disorders
- melanin and skin pigmentation
- Skin and Cellular Biology Research
- Oral Health Pathology and Treatment
- Autoimmune and Inflammatory Disorders Research
- Systemic Sclerosis and Related Diseases
- Genetic and rare skin diseases.
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Vascular Malformations and Hemangiomas
- Cancer and Skin Lesions
- Asthma and respiratory diseases
- Health Systems, Economic Evaluations, Quality of Life
- Skin Protection and Aging
- Cutaneous Melanoma Detection and Management
- Cancer-related molecular mechanisms research
Cairo University
2016-2025
Fayoum University
2021
Importance Generalized pustular psoriasis (GPP) lacks internationally accepted definitions and diagnostic criteria, impeding timely diagnosis treatment hindering cross-regional clinical epidemiological study comparisons. Objective To develop an international consensus definition criteria for GPP using the modified Delphi method. Evidence Review The rarity of presents a challenge in acquiring comprehensive published data necessary developing standardized criteria. Instead relying on...
Evaluation of serum ferritin and vitamin D levels in females with chronic telogen effluvium (TE) or female pattern hair loss (FPHL), order to validate their role these common diseases.Eighty (18 45 years old) loss, the form TE FPHL, 40 age-matched no were included study. Diagnosis was based upon clinical examination as well trichogram dermoscopy. Serum D2 determined for each participant.Serum (14.7 ± 22.1 μg/l) FPHL (23.9 38.5 candidates significantly lower than controls (43.5 20.4 μg/l)....
Identification of epidemiologic and phenotypic variations psoriasis among different ethnic groups can further our understanding this perplexing disease, aiming at better management patients worldwide.To provide a descriptive analysis registered Kasr Al-Ainy Psoriasis Unit Disease Registry.This retrospective single-center registry study included patient records between November 2015 2018 (2534 patients). Sociodemographic data were analyzed.The mean age the was 39.3 years 56.3% men. Stress...
Oral propranolol has become the treatment of choice infantile hemangiomas (IH)s. However, safety systemic is questioned. Topical therapy with 1% been reported to be safe and effective. Intralesional (IL) administration may possibly allow delivery higher drug dosages. To assess efficacy two locally administered routes (topical IL), in comparison its oral use IHs. 45 patients IHs were randomly divided into 3 groups, A, B C (n = 15 each), receiving propranolol, 2 mg/kg/day, topical ointment...
Abstract Background Keratinocyte acantholysis as a result of pathogenic Dsg3‐antibodies production by B cells leads to Pemphigus vulgaris ( PV ). Vitamin D, through its participation in several immune modulatory functions including apoptosis, Th2 cell differentiation, apoptotic enzyme regulation and Tregs functions, may be actively involved the . Objective To evaluate D status patients comparison controls an attempt determine role this autoimmune disease. Methods Using ELISA technique,...
ABSTRACT Nail involvement in psoriasis was reported 10%–55% of patients. treatment can be more challenging than treating skin lesions for lack adequate absorption topical agents plus the slower nail turnover. To study demographic and clinical characteristics patients with compared to without involvement. Retrospective analysis all attending unit between 2015 2020 performed. Patients were accordingly. A total 2888 included analysis, 2363 which had no 525 nails (18%). significantly higher...
ABSTRACT Oral erosions and ulcers of pemphigus vulgaris (PV) are a debilitating condition that is usually difficult to treat. The wound healing properties platelet‐rich plasma (PRP) encouraged us evaluate its usefulness in treatment non‐healing oral PV lesions. Seven patients with chronic PV, resistant conventional therapy, were treated weekly monthly injections PRP affected mucosal membranes. All recruits reported improvement pain mastication 6 7 had an disease area index scores treatment....
Summary Tinea infections are among the most common dermatological conditions throughout world. Griseofulvin is a classical oral fungistatic antibiotic, active against Epidermophyton floccosum , Trichophyton and Microsporum species, causative fungi of tinea corporis. To evaluate efficacy topical griseofulvin in treatment circinata using three different vehicles for drug delivery. Sixteen patients with were instructed to apply either gel form group A or similar placebo control group; niosomal...
Acne scarring is common but surprisingly difficult to treat. Newer techniques and modifications older ones may make this refractory problem more manageable. The 100% trichloroacetic acid (TCA) chemical reconstruction of skin scars (CROSS) method a safe effective single modality for the treatment atrophic acne scars, whereas subcision appears be technique that provides significant improvement rolling scars.To compare effect TCA CROSS with in treating scars.Twenty patients types III IV...
In psoriasis, keratinocyte hyperplasia may be explained by imbalance of growth factors responsible for epidermal proliferation and altered metabolism their receptors. Transforming factor-beta 1 (TGF-beta1) implications in the pathogenesis psoriasis can attributed to several mechanisms besides cell cycle inhibition.To evaluate relation between serum tissue levels TGF-beta1 correlation with disease parameters.Serum punch biopsy involved non-involved skin 22 patients vulgaris 10 controls were...
<b><i>Background:</i></b> Vertical tumor thickness according to Breslow and histological ulceration are still the most powerful predictors for clinical outcome of resectable cutaneous malignant melanoma (MM) without lymph node infiltration. It has been proposed that volume in MM may also be prognostic relevance. <b><i>Methods:</i></b> We retrospectively analyzed impact other established risk factors 122 patients with a median follow-up period...
Psoriasis is an immune-mediated disease, with genetic background and triggering environmental factors; however, several gaps are still present in understanding the intertwined relationship between these elements. Epigenetic mechanisms, including microRNAs (miRNAs), play important role pathogenesis of psoriasis. The interleukin (IL)-17, a key cytokine psoriasis, epigenetic mechanisms needs to be elucidated. This study aimed at assessing expression miRNA-155, miRNA-210, miRNA-20b skin sera...
To the Editor: A 32-year-old man presented to our clinic with acuteonset erythroderma associated severe itching of 1 month's duration.The patient developed eruption after receiving second dose Sinopharm BBIBP COVID-19 vaccine (BBIBP-CorV) 2 weeks prior presentation.His medical history was unremarkable.There no personal or family skin disease and drug intake.Physical examination revealed orange-red (Figure 1A) islands sparing, keratotic follicular papules on both legs feet 1B), well-defined...
Melasma is a common condition that affects patient's quality of life. Metformin cheap, well-tolerated and relatively safe medication widely prescribed for the treatment diabetes. Topical metformin has shown promising results in treating melasma as well several other dermatological conditions such acne recalcitrant central centrifugal cicatricial alopecia.
Summary Background The side effects of mesotherapy for treatment various forms alopecia are often underreported, while scientific data its efficacy severely lacking. Objective To demonstrate the late onset alopecia. Methods Three patients with androgenetic showed hair loss after previously uneventful sessions up to 1 year. Results Clinical, dermoscopic, and histopathological findings suggested an inflammatory scaring process at sites injections. Conclusion Mesotherapy may paradoxically...
Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays role in the immunopathogenesis of Behcet's disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members tumor family. BAFF binds to 3 receptors, receptor (BAFF-R), transmembrane activator calcium modulator interactor (TACI), maturation antigen (BCMA) that expressed by cells.Estimation serum levels TNF-α, APRIL, BAFF, BCMA patients with BD effort...
Summary Background A poloxamer solution acting as a vehicle for the lipid base particulate system (cubosome dispersions) containing alpha lipoic acid ( ALA ) has achieved encouraging results in skin aging. Objective Evaluate efficacy of 5% Cubosomal an anti‐aging formulation. Methods This single‐blinded, placebo‐controlled, comparative study was conducted on 20 females. Patients were instructed to apply gel formulation active ingredient over right half their face and placebo left twice daily...
Psoriasis is a chronic skin disorder manifested by recurrent episodes of scaly, red, itchy patches that occur within apparently normal skin.This study was performed to detect the expression serum and tissue (lesion non-lesion) LncRNA MALAT-1 MiRNA-9 might be used as biomarkers for psoriasis.Blood samples were obtained from 60 psoriasis patients 40 controls, well 4 mm punch biopsy lesional non psoriatic patient healthy controls. Expression miRNNA-9 in tissues detected real time qRT-PCR.a...